Abstract: A polydioxanone film comprising substantially cylindrical polydioxanone pillars on at least one side thereof, said pillars having diameters from about 0.2 ?m to about 3 ?m, and heights from about 2 ?m to about 20 ?m from the surface of the film, a process for adsorbing proteins using the film and medical devices incorporating the film.

Abstract: This invention discloses methods and apparatus for providing an ophthalmic lens with a textured pattern within an optic zone and an ophthalmic lens with a textured pattern within the optic zone.

Abstract: A polydioxanone film comprising substantially cylindrical polydioxanone pillars on at least one side thereof, said pillars having diameters from about 0.2 ?m to about 3 ?m, and heights from about 2 ?m to about 20 ?m from the surface of the film, a process for adsorbing proteins using the film and medical devices incorporating the film.

Abstract: A laminate and process of making the laminate is disclosed comprising: a surgical mesh having first and second surfaces; and an adhesive structure having adhesive and non-adhesive surfaces, wherein the non-adhesive surface of the adhesive structure is laminated to at least one of said first and second surfaces of said surgical mesh, and the adhesive surface of said adhesive structure has protrusions extending therefrom comprising a resin having a Young's modulus of greater than 17 MPa, which protrusions are of sufficiently low diameter to promote adhesion by increasing physical attractive forces between the adhesive structure and a target surface, as measured by shear adhesion.

Abstract: The present invention relates to tissue scaffold implant devices useful in the repair and/or regeneration of diseased and/or damaged musculoskeletal tissue and that include a tissue scaffold component fixedly attached to a scaffold fixation component via a polymeric adhesive layer, and to methods of making such tissue scaffold implant devices.

Abstract: An adhesive structure is provided comprising a surface from which extend substantially cylindrical protrusions comprising a stiff resin having a Young's modulus of greater than 17 MPa. The protrusions are of sufficiently low diameter to promote adhesion by physical attractive forces, e.g., Van der Waals attractive forces, as measured by shear adhesion between the adhesive structure and a target surface. A method for preparing the structure is provided as well as a combination of the adhesive structure and target surface.

Abstract: This invention discloses methods and apparatus for providing an ophthalmic lens with a textured pattern within an optic zone and an ophthalmic lens with a textured pattern within the optic zone.

Abstract: Compositions and methods for the treatment of tumors are disclosed. Specifically, the present invention provides hollow foam beads having a chemotherapeutic agent incorporated therein. A method of making such beads is disclosed. In addition, a method for treating a glioblastoma tumor and other types of tumors with the compressible hollow foam beads is disclosed.

Abstract: A polymeric coating is applied to at least one embolic coil carried in a fixture, at least a portion of said embolic coil being generally vertical and straight. The coil is carried in the fixture during the processing, and may remain in the fixture if desired for further steps of processing.

Abstract: The present patent describes a biocompatible composite made of a first fibrous layer attached to a three-dimensional inter-connected open cell porous foams that have a gradient in composition and/or microstructure through one or more directions. These composites can be made from blends of absorbable and biocompatible polymers. These biocompatible composites are particularly well suited to tissue engineering applications and can be designed to mimic tissue transition or interface zones.

Abstract: The present invention is directed to reinforced, biocompatible, biodegradable compositions suitable for use in implantable medical devices and medical devices made at least in part from such compositions, where the compositions include a biocompatible, biodegradable polymer; a biocompatible, biodegradable wax; and greater than about 30 weight percent of an inorganic filler material.

Abstract: The present invention is directed to reinforced, biocompatible, biodegradable compositions suitable for use in implantable medical devices and medical devices made at least in part from such compositions, where the compositions include a biocompatible, biodegradable polymer; a biocompatible, biodegradable wax; and greater than about 30 weight percent of an inorganic filler material.

Abstract: The present invention relates to tissue scaffold implant devices useful in the repair and/or regeneration of diseased and/or damaged musculoskeletal tissue and that include a tissue scaffold component fixedly attached to a scaffold fixation component via a polymeric adhesive layer, and to methods of making such tissue scaffold implant devices.

Abstract: A biocompatible tissue implant, as well as methods for making and using such an implant, is provided. Preferably, the tissue implant is bioabsorbable. The tissue implant comprises one or more layers of a bioabsorbable polymeric foam having pores with an open cell structure. The tissue implant also includes a reinforcement component which contributes both to the mechanical and the handling properties of the implant. Preferably, the reinforcement component of the instant invention is bioabsorbable as well. The tissue implant of the present invention can be used in connection with the surgical repair of soft tissue injury, such as injury to the pelvic floor.

Abstract: A biocompatible tissue implant, as well as methods for making and using such an implant, is provided. Preferably, the tissue implant is bioabsorbable. The tissue implant comprises one or more layers of a bioabsorbable polymeric foam having pores with an open cell structure. The tissue implant also includes a reinforcement component which contributes both to the mechanical and the handling properties of the implant. Preferably, the reinforcement component is bioabsorbable as well. The tissue implant provided can be used in connection with the surgical repair of soft tissue injury, such as injury to the pelvic floor.

Abstract: The present patent describes a biocompatible composite made of a first fibrous layer attached to a three-dimensional inter-connected open cell porous foams that have a gradient in composition and/or microstructure through one or more directions. These composites can be made from blends of absorbable and biocompatible polymers. These biocompatible composites are particularly well suited to tissue engineering applications and can be designed to mimic tissue transition or interface zones.

Abstract: The present patent describes a three-dimensional inter-connected open cell porous foams that have a gradient in composition and/or microstructure through one or more directions. These foams can be made from a blend of absorbable and biocompatible polymers that are formed into foams having a compositional gradient transitioning from predominately one polymeric material to predominately a second polymeric material. These gradient foams are particularly well suited to tissue engineering applications and can be designed to mimic tissue transition or interface zones.

Abstract: A biocompatible tissue implant, as well as methods for making and using such an implant, is provided. Preferably, the tissue implant is bioabsorbable. The tissue implant comprises one or more layers of a bioabsorbable polymeric foam having pores with an open cell structure. The tissue implant also includes a reinforcement component which contributes both to the mechanical and the handling properties of the implant. Preferably, the reinforcement component of the instant invention is bioabsorbable as well. The tissue implant of the present invention can be used in connection with the surgical repair of soft tissue injury, such as injury to the pelvic floor.

Abstract: The present patent describes a three-dimensional interconnected open cell porous foams that have a gradient in composition and/or microstructure through one or more directions. These foams can be made from a blend of absorbable and biocompatible polymers that are formed into foams having a compositional gradient transitioning from predominately one polymeric material to predominately a second polymeric material. These gradient foams are particularly well suited to tissue engineering applications and can be designed to mimic tissue transition or interface zones.

Abstract: The present invention provides an improved lyophilization process for forming biocompatible foam structures. The process allows the foam structures to be tailored for specific end uses. The foams formed by this process are well suited to be used in medical applications such as tissue engineering.