Abstract: A system computes a timing interval between high-capacity vehicles (HCVs) for each of a plurality of HCV corridors within a geographic region, each respective HCV corridor of the plurality of HCV corridors including a start area. For each respective HCV corridor, the system transmits, via a network communication interface, (i) first data to a first computing device associated with a first HCV, the first data indicating the start area of the respective HCV corridor, and a first start time for the first HCV, and (ii) second data to a second computing device associated with a second HCV, the second data indicating the start area of the respective HCV corridor and a second start time for the second HCV, wherein the first start time for the first HCV and the second start time for the second HCV are based on the computed timing interval for the respective HCV corridor.

Abstract: Provided herein are methods of treating neurodevelopmental disorders, including the treatment of Tuberous sclerosis complex (TSC), with pharmaceutical compositions containing heat shock protein (Hsp) inhibitors and/or mTOR inhibitors. Also provided herein are methods for inhibiting mechanistic target of rapamycin complex 1 (mTORC1) activity and/or increasing or normalizing ciliation.

Abstract: A computing system computes a timing interval between high-capacity vehicles (HCVs) for each HCV corridor within a geographic region to control rates of HCVs entering and exiting each of the HCV corridors. For each of the HCV corridors, the computing system schedules a first HCV to provide a transport service along the corridor beginning at a first starting time, transmits first schedule data for the corridor to the first HCV, schedules a second HCV to provide the transport service along the corridor beginning at a second starting time after the first starting time according to the timing interval for the corridor, and transmits second schedule data for the corridor to the second HCV.

Abstract: A system computes a timing interval between high-capacity vehicles (HCVs) for each of a plurality of HCV corridors within a geographic region, each respective HCV corridor of the plurality of HCV corridors including a start area. For each respective HCV corridor, the system transmits, via a network communication interface, (i) first data to a first computing device associated with a first HCV, the first data indicating the start area of the respective HCV corridor, and a first start time for the first HCV, and (ii) second data to a second computing device associated with a second HCV, the second data indicating the start area of the respective HCV corridor and a second start time for the second HCV, wherein the first start time for the first HCV and the second start time for the second HCV are based on the computed timing interval for the respective HCV corridor.

Abstract: A network system can receive a first request for a transport service and a second request for the transport service. The system can identify, from a plurality of service providers, a first set of service providers for the first request, and a second set of service providers for the second request. Based on a first set of predictive parameters for the first set of service providers, the system implements a multi-invite mode by transmitting a first invitation data set to service the first request to a plurality of provider devices of the first set of service providers. Based on a second set of predictive parameters for the second set of service providers, the system implements an exclusive-invite mode by transmitting a second invitation data set to a provider device of a selected service provider of the second set of service providers.

Abstract: A computing system computes a timing interval between high-capacity vehicles (HCVs) for each HCV corridor within a geographic region to control rates of HCVs entering and exiting each of the HCV corridors. For each of the HCV corridors, the computing system schedules a first HCV to provide a transport service along the corridor beginning at a first starting time, transmits first schedule data for the corridor to the first HCV, schedules a second HCV to provide the transport service along the corridor beginning at a second starting time after the first starting time according to the timing interval for the corridor, and transmits second schedule data for the corridor to the second HCV.

Abstract: A computing system can detect high capacity vehicles (HCVs) coming online to provide transport services. The computing system monitors transport demand for HCV corridors throughout a geographic region. Each HCV corridor comprises a plurality of possible rendezvous locations and a plurality of possible routes that can be traveled by individual HCVs through the HCV corridor, as opposed to having fixed routes with fixed stops. The computing system can determine a schedule for each HCV corridor, and monitor supply flow of HCVs traveling through each HCV corridor. Based on (i) the transport demand, (ii) the schedule, and (iii) the supply flow of the HCVs for each of the HCV corridors, the computing system can match the HCV with a specified HCV corridor, and transmit match data indicating a start zone of the matching HCV corridor to the computing device of the HCV.

Abstract: A computing system can assign a transport request to a high capacity vehicle (HCV) corridor of a plurality of HCV corridors, where the HCV corridor is associated with a plurality of possible rendezvous locations and a plurality of possible routes that can be traveled by individual HCVs. The computing system can determine, from the transport request of the requesting user, an optimal pick-up location from the plurality of possible rendezvous locations of the HCV corridor for an HCV to rendezvous with the requesting user.

Abstract: An anvil cap for providing secure anastomosis in a circular staplers in which the anvil cap has a movable inner shaft, a command wire connected to the movable inner shaft so as to cause a pulling movement to be applied to the movable inner shaft, a plurality of upper wings pivotally mounted to joint points on the movable inner shaft so as to be openable in relation to the movable inner shaft, and a plurality of lower wings cooperative with the plurality of upper wings such that the plurality of lower wings open when the plurality of upper wings apply pressure to the plurality of lower wings.

Abstract: An anvil cap providing secure anastomosis in the circular staplers having a main body, a clamping arm configured on the body, a punch section and a punch surface corresponding to the punch section; characterized in comprising a movable inner shaft on which a pulling movement is applied by means of a command wire, upper wings which are made to open by means of the joint points of the movable inner shaft, lower wings which are made to open when the upper wings apply a pressure on the lower wings after they open and apply a pulling movement, and an anvil cap configured upon the combination of these two-level wings.

Abstract: A foldable anvil provides secure anastomosis in circular staplers and has an anvil cap with a main body, a clamping arm configured on the main body, a punch section and a punch surface corresponding to the punch section. The anvil cap includes multiple foldable wings, a command wire connected with the wings, and a wire wrap pulley directing the command wire.

Abstract: The present invention provides a system and method for transmitting an ultrawideband (UWB) signal that is composed of an orthogonal frequency-division multiplexing (OFDM) based signal that is transmitted in an underlay manner and an impulse radio based signal that is transmitted in an overlay manner. The system and method are effective in determining an interference temperature for each of multiple carriers within the UWB signal and classifying each one of the multiple carriers of the channel as being an interfered carrier or a non-interfered carrier based on the interference temperature for each one of multiple carriers. The desired signal is then transmitted on the interfered carriers at a signal power that is not greater than the power limit of the underlay UWB policy and on the non-interfered carriers at a signal power that is greater than the power limit of the underlay UWB policy.