Abstract: Mesothelioma growth inhibitory effect of standard cisplatin-pemetrexed concomitant therapy is potentiated by combination with an anti-CD26 antibody. A high therapeutic effect and excellent safety is obtained by the concomitant use of an anti-CD26 antibody and gemcitabine. By conjugating an anti-CD26 antibody (YS110) with triptolide via a divalent cross-linking agent for concomitant therapy using the anti-CD26 antibody, a novel antibody-drug conjugate (Y-TR1) very highly effective for CD26-positive malignant mesothelioma cells has been successfully obtained.

Abstract: Mesothelioma growth inhibitory effect of standard cisplatin-pemetrexed concomitant therapy is potentiated by combination with an anti-CD26 antibody. A high therapeutic effect and excellent safety is obtained by the concomitant use of an anti-CD26 antibody and gemcitabine. By conjugating an anti-CD26 antibody (YS110) with triptolide via a divalent cross-linking agent for concomitant therapy using the anti-CD26 antibody, a novel antibody-drug conjugate (Y-TR1) very highly effective for CD26-positive malignant mesothelioma cells has been successfully obtained.

Abstract: A plurality of cartridges are set to a cartridge standby section. Each cartridge has a specimen tub, a dilution tub and three reaction tubs, and a specimen is placed in the specimen tub in advance. A specimen dispensing unit first distributes the specimen from the specimen tub to three reaction tubs of the same cartridge. Thereafter the cartridges are successively transported to a first reagent dispensing section, a first reaction path, a second dispensing section, a second reaction path, an unreacted component removing section, a luminescent reagent dispensing section and a hydrogen peroxide dispensing section in the stated order. Examination processes including reagent dispensing and unreacted component removal are carried out simultaneously for the three reaction tubs of each cartridge. Finally, reaction mixtures are subjected to photometry in a photometric section.

Abstract: An ultraviolet ray measuring apparatus is provided which comprises first and second photodiodes having substantially the same spectral sensitivity at least in an ultraviolet band, and a first optical filter arranged in front of a light-receiving face of the second photodiode, for shielding only light of at least a part of the ultraviolet band. The apparatus measures the light intensity and its accumulated value in accordance with the difference between electric signals output from the first and second photodiodes. It is preferable that a second optical filter, which has a main transmitting band in the ultraviolet band and a sub-transmitting band in the visible light range, be arranged in front of the light-receiving faces of the first and second photodiode.