Patents by Inventor Mutsuyuki Sugimori
Mutsuyuki Sugimori has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9295526Abstract: A cochlear implant device includes a deformable and stretchable flexible strip composed of a biological compatible material and positioned about a longitudinal axis so as to form a spiral. The implant device has a plurality of conductive strips with electrode windows formed so as to expose a segment of each conductive strip. A density of the electrode windows is sufficient to monitor a distance of the flexible strip from a non-conductive tissue of a patient in a 360 degree field of view about the longitudinal axis. A method of inserting a cochlear implant includes providing a multi-joint robot comprised of a series of actuator units, guiding the multi-joint robot into an inner ear of a patient, monitoring the position of the multi-joint robot relative to a non-conductive portion of the patient; and applying current to the multi joint robot so as to adjust the position of the actuator units.Type: GrantFiled: November 8, 2013Date of Patent: March 29, 2016Assignee: New York UniversityInventors: Rodolfo R. Llinas, Hirobumi Watanabe, Mutsuyuki Sugimori, Masayuki Nakao
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Publication number: 20140220036Abstract: The present invention provides methods of inhibiting a tau protein such as h-tau42 or a biologically active fragment, derivative or analog thereof, methods of treating a disease caused by a tau protein such as h-tau42, and methods to identify agents that may inhibit a tau protein such as h-tau42. The methods for identifying an agent effective to inhibit a tau protein may feature administering an agent; and observing either i) a reduction in biological activity of the tau protein or a biologically active fragment, derivative or analog thereof or ii) a reduction in phosphorylation of the tau protein or a biologically active fragment, derivative or analog thereof.Type: ApplicationFiled: February 1, 2013Publication date: August 7, 2014Inventors: Rodolfo R. Llinas, Herman Moreno, Mutsuyuki Sugimori
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Publication number: 20140066951Abstract: A cochlear implant device includes a deformable and stretchable flexible strip composed of a biological compatible material and positioned about a longitudinal axis so as to form a spiral. The implant device has a plurality of conductive strips with electrode windows formed so as to expose a segment of each conductive strip. A density of the electrode windows is sufficient to monitor a distance of the flexible strip from a non-conductive tissue of a patient in a 360 degree field of view about the longitudinal axis. A method of inserting a cochlear implant includes providing a multi-joint robot comprised of a series of actuator units, guiding the multi-joint robot into an inner ear of a patient, monitoring the position of the multi-joint robot relative to a non-conductive portion of the patient; and applying current to the multi joint robot so as to adjust the position of the actuator units.Type: ApplicationFiled: November 8, 2013Publication date: March 6, 2014Applicant: NEW YORK UNIVERSITYInventors: Rodolfo R. Llinas, Hirobumi Watanabe, Mutsuyuki Sugimori, Masayuki Nakao
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Patent number: 8614254Abstract: This invention relates to methods of inhibiting a Cav3 calcium channel in a cell using a C2-C10 alkyl alcohol, or mixtures thereof. This invention further relates to methods of treating a thalamocortical dysrhythmia disorder in a mammal and for treating a neurological disorder in a mammal associated with the thalamocortical dysrhythmia using a C2-C10 alkyl alcohol, a lipophilic molecule with a partition coefficient substantially similar to that of a C2-C10 alkyl alcohol, or mixtures thereof, or a pharmaceutical composition comprising the same.Type: GrantFiled: July 26, 2010Date of Patent: December 24, 2013Assignee: New York UniversityInventors: Rodolfo R. Llinas, Mutsuyuki Sugimori, Francisco Urbano
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Patent number: 8583261Abstract: A cochlear implant device includes a deformable and stretchable flexible strip composed of a biological compatible material and positioned about a longitudinal axis so as to form a spiral. The implant device has a plurality of conductive strips with electrode windows formed so as to expose a segment of each conductive strip. A density of the electrode windows is sufficient to monitor a distance of the flexible strip from a non-conductive tissue of a patient in a 360 degree field of view about the longitudinal axis. A method of inserting a cochlear implant includes providing a multi-joint robot comprised of a series of actuator units, guiding the multi-joint robot into an inner ear of a patient, monitoring the position of the multi-joint robot relative to a non-conductive portion of the patient; and applying current to the multi-joint robot so as to adjust the position of the actuator units.Type: GrantFiled: August 14, 2012Date of Patent: November 12, 2013Assignee: New York UniversityInventors: Rodolfo R. Llinas, Hirobumi Watanabe, Mutsuyuki Sugimori, Masayuki Nakao
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Publication number: 20120310258Abstract: A cochlear implant device includes a deformable and stretchable flexible strip composed of a biological compatible material and positioned about a longitudinal axis so as to form a spiral. The implant device has a plurality of conductive strips with electrode windows formed so as to expose a segment of each conductive strip. A density of the electrode windows is sufficient to monitor a distance of the flexible strip from a non-conductive tissue of a patient in a 360 degree field of view about the longitudinal axis. A method of inserting a cochlear implant includes providing a multi-joint robot comprised of a series of actuator units, guiding the multi-joint robot into an inner ear of a patient, monitoring the position of the multi-joint robot relative to a non-conductive portion of the patient; and applying current to the multi-joint robot so as to adjust the position of the actuator units.Type: ApplicationFiled: August 14, 2012Publication date: December 6, 2012Inventors: Rodolfo R. LLINAS, Hirobumi Watanabo, Mutsuyuki Sugimori, Masayuki Nakao
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Patent number: 8315686Abstract: An electrode device and a method of installing the electrode device in the vicinity of the brain. The electrode device includes a plurality of electrode assemblies, each with at least one electrode lead, extending from a common base. The base is configured to be positioned on an outside of the patient's cranium with each electrode assembly projecting individually through a hole in the patient's cranium such that the electrode lead is in the vicinity of the brain. The method of installation includes carving a recess out of the patient's cranium and inserting the base therein. Each of the electrode assemblies are placed in their respective holes in order to stimulate, monitor or record neurological activity. The electrode device may be used over long periods of time for chronic treatment or recording.Type: GrantFiled: January 30, 2009Date of Patent: November 20, 2012Assignee: New York UniversityInventors: Rodolfo R. Llinas, Mutsuyuki Sugimori
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Patent number: 8260437Abstract: A cochlear implant device includes a deformable and stretchable flexible strip composed of a biological compatible material and positioned about a longitudinal axis so as to form a spiral. The implant device has a plurality of conductive strips with electrode windows formed so as to expose a segment of each conductive strip. A density of the electrode windows is sufficient to monitor a distance of the flexible strip from a non-conductive tissue of a patient in a 360 degree field of view about the longitudinal axis. A method of inserting a cochlear implant includes providing a multi-joint robot comprised of a series of actuator units, guiding the multi-joint robot into an inner ear of a patient, monitoring the position of the multi-joint robot relative to a non-conductive portion of the patient; and applying current to the multi-joint robot so as to adjust the position of the actuator units.Type: GrantFiled: October 28, 2009Date of Patent: September 4, 2012Assignee: New York UniversityInventors: Rodolfo R. Llinas, Hirobumi Watanabe, Mutsuyuki Sugimori, Masayuki Nakao
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Publication number: 20110098719Abstract: A cochlear implant device includes a deformable and stretchable flexible strip composed of a biological compatible material and positioned about a longitudinal axis so as to form a spiral. The implant device has a plurality of conductive strips with electrode windows formed so as to expose a segment of each conductive strip. A density of the electrode windows is sufficient to monitor a distance of the flexible strip from a non-conductive tissue of a patient in a 360 degree field of view about the longitudinal axis. A method of inserting a cochlear implant includes providing a multi-joint robot comprised of a series of actuator units, guiding the multi-joint robot into an inner ear of a patient, monitoring the position of the multi-joint robot relative to a non-conductive portion of the patient; and applying current to the multi-joint robot so as to adjust the position of the actuator units.Type: ApplicationFiled: October 28, 2009Publication date: April 28, 2011Applicant: New York UniversityInventors: Rodolfo R. Llinas, Hirobumi Watanabe, Mutsuyuki Sugimori, Masayuki Nakao
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Publication number: 20100292344Abstract: This invention relates to methods of inhibiting a Cav3 calcium channel in a cell using a C2-C10 alkyl alcohol, or mixtures thereof. This invention further relates to methods of treating a thalamocortical dysrhythmia disorder in a mammal and for treating a neurological disorder in a mammal associated with the thalamocortical dysrhythmia using a C2-C10 alkyl alcohol, a lipophilic molecule with a partition coefficient substantially similar to that of a C2-C10 alkyl alcohol, or mixtures thereof, or a pharmaceutical composition comprising the same.Type: ApplicationFiled: July 26, 2010Publication date: November 18, 2010Applicant: New York UniversityInventors: Rodolfo R. Llinas, Mutsuyuki Sugimori, Francisco Urbano
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Publication number: 20090192569Abstract: An electrode device and a method of installing the electrode device in the vicinity of the brain. The electrode device includes a plurality of electrode assemblies, each with at least one electrode lead, extending from a common base. The base is configured to be positioned on an outside of the patient's cranium with each electrode assembly projecting individually through a hole in the patient's cranium such that the electrode lead is in the vicinity of the brain. The method of installation includes carving a recess out of the patient's cranium and inserting the base therein. Each of the electrode assemblies are placed in their respective holes in order to stimulate, monitor or record neurological activity. The electrode device may be used over long periods of time for chronic treatment or recording.Type: ApplicationFiled: January 30, 2009Publication date: July 30, 2009Applicant: New York UniversityInventors: Rodolfo R. Llinas, Mutsuyuki Sugimori
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Publication number: 20080268067Abstract: This invention relates to methods of inhibiting a Cav3 calcium channel in a cell using a C2-C10 alkyl alcohol, or mixtures thereof. This invention further relates to methods of treating a thalamocortical dysrhythmia disorder in a mammal and for treating a neurological disorder in a mammal associated with the thalamocortical dysrhythmia using a C2-C10 alkyl alcohol, a lipophilic molecule with a partition coefficient substantially similar to that of a C2-C10 alkyl alcohol, or mixtures thereof, or a pharmaceutical composition comprising the same.Type: ApplicationFiled: March 10, 2008Publication date: October 30, 2008Inventors: Rodolfo R. Llinas, Mutsuyuki Sugimori, Francisco Urbano
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Patent number: 5432202Abstract: Methods for regulating cation transport across cellular membranes possessing cation channels are provided. The cell membrane possessing a specific ion channel is exposed to a non-aromatic polyamine compound having a lysine- or arginine-based moiety (or a guanidine moiety) coupled to a straight chain polyamine.These polyamines as well as a method for regulating NMDA through a spermidine-like effect on NMDA receptors by exposing a cell membrane to selected polyamines are also provided.Type: GrantFiled: June 9, 1993Date of Patent: July 11, 1995Assignee: New York UniversityInventors: Bruce D. Cherksey, Rodolfo R. Llinas, Mutsuyuki Sugimori
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Patent number: 5242947Abstract: Methods for regulating cation transport across cellular membranes possessing cation channels are provided. The cell membrane possessing a specific ion channel is exposed to a non-aromatic polyamine compound having a lysine- or arginine-based moiety (or a guanidine moiety) coupled to a straight chain polyamine.These polyamines as well as a method for regulating NMDA through a spermidine-like effect on NMDA receptors by exposing a cell membrane to selected polyamines are also provided.Type: GrantFiled: January 3, 1992Date of Patent: September 7, 1993Assignee: New York UniversityInventors: Bruce D. Cherksey, Rodolfo R. Llinas, Mutsuyuki Sugimori
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Patent number: 4950739Abstract: Nonpolypeptide factors isolated from the venom of funnel-web spiders are capable of binding calcium channel proteins. These nonpolypeptide factors are used to purify calcium channels and completely block voltage-dependant calcium conductance of cell membranes.Type: GrantFiled: July 14, 1988Date of Patent: August 21, 1990Assignee: New York UniversityInventors: Bruce D. Cherksey, Rodolfo R. Llinas, Mutsuyuki Sugimori
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Patent number: 4677982Abstract: A method and apparatus are disclosed for transcutaneous communication using infrared light signals to communicate bidirectionally between electronic apparatus implanted within a living organism and electronic apparatus external to the body by which measurements of physiological data can be obtained and command signals can be imposed on implanted apparatus.Type: GrantFiled: March 29, 1984Date of Patent: July 7, 1987Assignee: New York UniversityInventors: Llinas, Rodolfo R., Mutsuyuki Sugimori, Ronald K. Crank