Patents by Inventor Mutua Mattu
Mutua Mattu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7606608Abstract: An optical sampling interface system is disclosed that minimizes and compensates for errors that result from sampling variations and measurement site state fluctuations. Embodiments of the invention use a guide that does at least one of, induce the formation of a tissue meniscus, minimize interference due to surface irregularities, control variation in the volume of tissue sampled, use a two-part guide system, use a guide that controls rotation of a sample probe and allows z-axis movement of the probe, use a separate base module and sample module in conjunction with a guide, and use a guide that controls rotation. Optional components include an occlusive element and a coupling fluid.Type: GrantFiled: December 8, 2004Date of Patent: October 20, 2009Assignee: Sensys Medical, Inc.Inventors: Thomas B. Blank, George Acosta, Mutua Mattu, Marcy Makarewicz, Stephen L. Monfre, Alexander D. Lorenz, Timothy L. Ruchti, Kevin H. Hazen, Donovan D. Berry, Roxanne E. Abul-Haj
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Patent number: 7519406Abstract: A method and apparatus are provided for noninvasive sampling. More particularly, the method and apparatus relate to control of motion of an optical sample probe interface relative to a tissue sample site. A dynamic probe interface, is used to collect spectra of a targeted sample, control positioning of the sample probe relative to the tissue sample in terms of at least one of x-, y-, and z-axes, and/or control of sample tissue displacement to minimize spectral variations resulting from the sampling process and increase analyte property estimation precision and accuracy.Type: GrantFiled: April 27, 2005Date of Patent: April 14, 2009Assignee: Sensys Medical, Inc.Inventors: Thomas B. Blank, George M. Acosta, Timothy L. Ruchti, Mutua Mattu, Alexander D. Lorenz, Kevin H. Hazen, James R. Henderson
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Patent number: 7509153Abstract: A method and apparatus for noninvasive glucose measurement measures glucose indirectly from the natural response of tissue to variations in analyte concentration. The indirect measurement method utilizes factors affected by or correlated with the concentration of glucose, such as refractive index, electrolyte distribution or tissue scattering. Measurement reliability is greatly improved by stabilizing optical properties of the tissue at the measurement site, thus blood perfusion rates at the sample site are regulated. Perfusion is monitored and stabilized by spectroscopically measuring a control parameter, such as skin temperature, that directly affects perfusion. The control parameter is maintained in a range about a set point, thus stabilizing perfusion. Skin temperature is controlled using a variety of means, including the use of active heating and cooling elements, passive devices, such as thermal wraps, and through the use of a heated coupling medium having favorable heat transfer properties.Type: GrantFiled: March 7, 2003Date of Patent: March 24, 2009Assignee: Sensys Medical, Inc.Inventors: Thomas B. Blank, Timothy L. Ruchti, Mutua Mattu, Marcy Makarewicz, Stephen L. Monfre, Alexander D. Lorenz
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Publication number: 20080200783Abstract: A method and apparatus for noninvasive glucose measurement measures glucose indirectly from the natural response of tissue to variations in analyte concentration. The indirect measurement method utilizes factors affected by or correlated with the concentration of glucose, such as refractive index, electrolyte distribution or tissue scattering. Measurement reliability is greatly improved by stabilizing optical properties of the tissue at the measurement site, thus blood perfusion rates at the sample site are regulated. Perfusion is monitored and stabilized by spectroscopically measuring a control parameter, such as skin temperature, that directly affects perfusion. The control parameter is maintained in a range about a set point, thus stabilizing perfusion. Skin temperature is controlled using a variety of means, including the use of active heating and cooling elements, passive devices, such as thermal wraps, and through the use of a heated coupling medium having favorable heat transfer properties.Type: ApplicationFiled: March 7, 2003Publication date: August 21, 2008Inventors: Thomas Blank, Timothy Ruchti, Mutua Mattu, Marcy Makarewicz, Stephen Monfre, Alexander Lorenz
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Publication number: 20070149868Abstract: A method and apparatus using photostimulation to treat or pretreat a sample site prior to analyte property estimation is presented. More particularly, photonic-stimulation at and/or near at least one sample site is used to enhance perfusion of the sample site leading to reduced errors associated with sampling. This allows an analyte property determination in well perfused regions of the body while sampling at a more convenient less well perfused region of the body.Type: ApplicationFiled: October 4, 2006Publication date: June 28, 2007Inventors: Thomas Blank, Mutua Mattu, Stephen Monfre, Marcy Markarewicz
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Patent number: 7233816Abstract: An optical sampling interface system minimizes and compensates error resulting from sampling variations and measurement site state fluctuations. Components include: An optical probe placement guide having an aperture wherein the optical probe is received, facilitates repeatable placement accuracy on surface of a tissue measurement site with minimal, repeatable disturbance to surface tissue. The aperture creates a tissue meniscus that minimizes interference due to surface irregularities and controls variation in tissue volume sampled; an occlusive element placed over the tissue meniscus isolates the meniscus from environmental fluctuations, stabilizing hydration at the site and thus, surface tension; an optical coupling medium eliminates air gaps between skin surface and optical probe; a bias correction element applies a bias correction to spectral measurements, and associated analyte measurements. When the guide is replaced, a new bias correction is determined for measurements done with the new placement.Type: GrantFiled: August 12, 2004Date of Patent: June 19, 2007Assignee: Sensys Medical, Inc.Inventors: Thomas B. Blank, George Acosta, Mutua Mattu, Marcy Makarewicz, Stephen L. Monfre, Alexander D. Lorenz, Timothy L. Ruchti
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Patent number: 7206623Abstract: An optical sampling interface system minimizes and compensates error resulting from sampling variations and measurement site state fluctuations. Components include: An optical probe placement guide having an aperture wherein the optical probe is received, facilitates repeatable placement accuracy on surface of a tissue measurement site with minimal, repeatable disturbance to surface tissue. The aperture creates a tissue meniscus that minimizes interference due to surface irregularities and controls variation in tissue volume sampled; an occlusive element placed over the tissue meniscus isolates the meniscus from environmental fluctuations, stabilizing hydration at the site and thus, surface tension; an optical coupling medium eliminates air gaps between skin surface and optical probe; a bias correction element applies a bias correction to spectral measurements, and associated analyte measurements. When the guide is replaced, a new bias correction is determined for measurements done with the new placement.Type: GrantFiled: June 12, 2002Date of Patent: April 17, 2007Assignee: Sensys Medical, Inc.Inventors: Thomas B. Blank, George Acosta, Mutua Mattu, Marcy Makarewicz, Stephen L. Monfre, Alexander D. Lorenz, Timothy L. Ruchti
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Publication number: 20070060805Abstract: An optical sampling interface system minimizes and compensates error resulting from sampling variations and measurement site state fluctuations. Components include: An optical probe placement guide having an aperture wherein the optical probe is received, facilitates repeatable placement accuracy on surface of a tissue measurement site with minimal, repeatable disturbance to surface tissue. The aperture creates a tissue meniscus that minimizes interference due to surface irregularities and controls variation in tissue volume sampled; an occlusive element placed over the tissue meniscus isolates the meniscus from environmental fluctuations, stabilizing hydration at the site and thus, surface tension; an optical coupling medium eliminates air gaps between skin surface and optical probe; a bias correction element applies a bias correction to spectral measurements, and associated analyte measurements. When the guide is replaced, a new bias correction is determined for measurements done with the new placement.Type: ApplicationFiled: August 12, 2004Publication date: March 15, 2007Inventors: Thomas Blank, George Acosta, Mutua Mattu, Marcy Makarewicz, Stephen Monfre, Alexander Lorenz, Timothy Ruchti
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Publication number: 20060211931Abstract: The invention provides an adaptive mount for use in coupling a noninvasive analyte property analyzer to a living tissue sample site. The adaptive mount increases precision and accuracy of sampling by relieving stress and strain on a sample prior to and/or during sampling, which results in noninvasive analyte property estimations with corresponding performance enhancement.Type: ApplicationFiled: February 21, 2006Publication date: September 21, 2006Inventors: Thomas Blank, Mutua Mattu, James Henderson, Kevin Hazen, Roxanne Abul-Haj
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Publication number: 20050267341Abstract: An optical sampling interface system minimizes and compensates error resulting from sampling variations and measurement site state fluctuations. Components include: an optical probe placement guide having an aperture wherein the optical probe is received, facilitates repeatable placement accuracy on surface of a tissue measurement site with minimal, repeatable disturbance to surface tissue. The aperture creates a tissue meniscus that minimizes interference due to surface irregularities and controls variation in tissue volume sampled; an occlusive element placed over the tissue meniscus isolates the meniscus from environmental fluctuations, stabilizing hydration at the site and thus, surface tension; an optical coupling medium eliminates air gaps between skin surface and optical probe; a bias correction element applies a bias correction to spectral measurements, and associated analyte measurements. When the guide is replaced, a new bias correction is determined for measurements done with the new placement.Type: ApplicationFiled: July 8, 2005Publication date: December 1, 2005Inventors: Thomas Blank, George Acosta, Mutua Mattu, Stephen Monfre
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Publication number: 20050267342Abstract: A method and apparatus are provided for noninvasive sampling. More particularly, the method and apparatus relate to control of motion of an optical sample probe interface relative to a tissue sample site. A dynamic probe interface, is used to collect spectra of a targeted sample, control positioning of the sample probe relative to the tissue sample in terms of at least one of x-, y-, and z-axes, and/or control of sample tissue displacement to minimize spectral variations resulting from the sampling process and increase analyte property estimation precision and accuracy.Type: ApplicationFiled: April 27, 2005Publication date: December 1, 2005Inventors: Thomas Blank, George Acosta, Timothy Ruchti, Mutua Mattu, Alexander Lorenz, Kevin Hazen, James Henderson
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Publication number: 20050203359Abstract: An optical sampling interface system is disclosed that minimizes and compensates for errors that result from sampling variations and measurement site state fluctuations. Embodiments of the invention use a guide that does at least one of, induce the formation of a tissue meniscus, minimize interference due to surface irregularities, control variation in the volume of tissue sampled, use a two-part guide system, use a guide that controls rotation of a sample probe and allows z-axis movement of the probe, use a separate base module and sample module in conjunction with a guide, and use a guide that controls rotation. Optional components include an occlusive element and a coupling fluid.Type: ApplicationFiled: December 8, 2004Publication date: September 15, 2005Inventors: Thomas Blank, George Acosta, Mutua Mattu, Marcy Makarewicz, Stephen Monfre, Alexander Lorenz, Timothy Ruchti, Kevin Hazen, Donovan Berry, Roxanne Abul-Haj
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Publication number: 20050054908Abstract: A method and apparatus using photo-stimulation to treat or pretreat a sample site prior to analyte concentration determination is presented. More particularly, photo-stimulation at or near at least one sample site is used to enhance perfusion of the sample site leading to reduced errors associated with sampling. Increased perfusion of the sample site leads to increased volume percentages of the target analyte and/or allows the blood or tissue constituent concentrations to more accurately and/or precisely track corresponding sample constituents in more well perfused body compartments or sites such as arteries, veins, or fingertips. In one embodiment, analysis of the photo-stimulated site is used in conjunction with glucose analyzers to determine the analyte concentration with greater ease, accuracy, or precision and may allow determination of the analyte concentration of another non-sampled body part or compartment.Type: ApplicationFiled: May 6, 2004Publication date: March 10, 2005Inventors: Thomas Blank, Stephen Monfre, Marcy Makarewicz, Mutua Mattu, Kevin Hazen, James Henderson
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Publication number: 20050049466Abstract: An optical sampling interface system minimizes and compensates error resulting from sampling variations and measurement site state fluctuations. Components include: An optical probe placement guide having an aperture wherein the optical probe is received, facilitates repeatable placement accuracy on surface of a tissue measurement site with minimal, repeatable disturbance to surface tissue. The aperture creates a tissue meniscus that minimizes interference due to surface irregularities and controls variation in tissue volume sampled; an occlusive element placed over the tissue meniscus isolates the meniscus from environmental fluctuations, stabilizing hydration at the site and thus, surface tension; an optical coupling medium eliminates air gaps between skin surface and optical probe; a bias correction element applies a bias correction to spectral measurements, and associated analyte measurements. When the guide is replaced, a new bias correction is determined for measurements done with the new placement.Type: ApplicationFiled: August 12, 2004Publication date: March 3, 2005Inventors: Thomas Blank, George Acosta, Mutua Mattu, Marcy Makarewicz, Stephen Monfre, Alexander Lorenz, Timothy Ruchti
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Patent number: 6839584Abstract: An apparatus and method for reproducibly interfacing a living tissue sample to the measurement probe of a spectrometer instrument in-situ minimizes spectral interference related to sampling variations. A minimal contact subject interface includes supports replaceably mounted on a base. An optical coupling means, such as a fiber optic probe, contacts the measurement site through a probe aperture in the base. During use, a subject rests an extremity on the support elements, so that the extremity is reproducibly positioned and supported in relation to the optical coupling means. The supports have a small contact area, minimizing contact with the skin at the measurement site. The interface module is adjustable to fit any subject. By reproducibly positioning and supporting the body appendage using minimal contact supports, spectral interference due to variations in placement, applied pressure, and temperature transients secondary to contact with the interface module are greatly minimized.Type: GrantFiled: September 17, 2001Date of Patent: January 4, 2005Assignee: Instrumentation Metrics, Inc.Inventors: Marcy Makarewicz, Mutua Mattu, Thomas B. Blank, George Acosta, Edward Handy, William Hay, Timothy Stippick, Benjamin Richie
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Patent number: 6788965Abstract: An intelligent system for detecting errors and determining failure modes operates on an absorbance spectrum of in vivo skin tissue. Application of the system results in improved prediction accuracy through rejection of invalid and poor samples. System components include a noninvasive blood glucose meter, such as a near IR spectrometer, an error detection system (EDS); a system for diagnosing and mitigating errors; and a reporting method. In the EDS, a pattern classification engine and hierarchy of levels analyzes, detects and diagnoses instrument, interface and sample errors manifested in the spectrum to determine suitability of an absorbance spectrum for blood glucose measurement. The final component of the system evaluates the error condition, diagnoses the specific mode of failure (if necessary) and reports actions to be taken. Sub-components and levels of the EDS can operate independently of the other system elements to the benefit of a noninvasive glucose measurement system.Type: GrantFiled: August 1, 2002Date of Patent: September 7, 2004Assignee: Sensys Medical, Inc.Inventors: Timothy L. Ruchti, Christopher C. Briggs, Thomas B. Blank, Alexander D. Lorenz, Mutua Mattu, Marcy Makarewicz
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Patent number: 6738652Abstract: A method for classifying live subjects according to optical thickness of the skin is based on noninvasive, near-infrared reflectance measurements on skin tissue. An indicator of skin optical thickness is derived through analysis of the water, fat, and protein marker bands in the near infrared spectrum. The skin thickness indicator may then be used to evaluate the suitability of the subject for calibration on a standardized set of optical probes. The optical probes in the standardized set are designed to cover a range of penetration depths by varying the distance distribution between illuminator and detector fibers on each probe tip.Type: GrantFiled: December 9, 2002Date of Patent: May 18, 2004Assignee: Sensys Medical, Inc.Inventors: Mutua Mattu, Thomas B. Blank, Marcy R. Makarewicz, Branden Rosenhan
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Publication number: 20040039271Abstract: A method and apparatus for noninvasive glucose measurement measures glucose indirectly from the natural response of tissue to variations in analyte concentration. The indirect measurement method utilizes factors affected by or correlated with the concentration of glucose, such as refractive index, electrolyte distribution or tissue scattering. Measurement reliability is greatly improved by stabilizing optical properties of the tissue at the measurement site, thus blood perfusion rates at the sample site are regulated. Perfusion is monitored and stabilized by spectroscopically measuring a control parameter, such as skin temperature, that directly affects perfusion. The control parameter is maintained in a range about a set point, thus stabilizing perfusion. Skin temperature is controlled using a variety of means, including the use of active heating and cooling elements, passive devices, such as thermal wraps, and through the use of a heated coupling medium having favorable heat transfer properties.Type: ApplicationFiled: March 7, 2003Publication date: February 26, 2004Inventors: Thomas B. Blank, Timothy L. Ruchti, Mutua Mattu, Marcy Makarewicz, Stephen L. Monfre, Alexander D. Lorenz
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Publication number: 20030208111Abstract: A method for classifying live subjects according to optical thickness of the skin is based on noninvasive, near-infrared reflectance measurements on skin tissue. An indicator of skin optical thickness is derived through analysis of the water, fat, and protein marker bands in the near infrared spectrum. The skin thickness indicator may then be used to evaluate the suitability of the subject for calibration on a standardized set of optical probes. The optical probes in the standardized set are designed to cover a range of penetration depths by varying the distance distribution between illuminator and detector fibers on each probe tip.Type: ApplicationFiled: December 9, 2002Publication date: November 6, 2003Inventors: Mutua Mattu, Thomas B Blank, Marcy R Makarewicz, Branden Rosenhan
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Patent number: 6640117Abstract: A method and apparatus for minimizing confounding effects in a noninvasive in-vivo spectral measurement caused by fluctuations in tissue state monitors a selected tissue state parameter spectroscopically and maintains the selected parameter within a target range, at which spectral effects attributable to the changes in the selected parameter are minimized. The invention includes both active and passive control. A preferred embodiment of the invention provides a method and apparatus for minimizing the confounding effects in near IR spectral measurements attributable to shifts in skin temperature at a tissue measurement site. Spectroscopic monitoring of skin temperature at the measurement site provides near-instantaneous temperature readings by eliminating thermal time constants. A thermistor positioned at the measurement site provides active control. The spectrometer and the temperature control device are incorporated into a single instrument for noninvasive measurement of blood glucose concentration.Type: GrantFiled: September 17, 2001Date of Patent: October 28, 2003Assignee: Sensys Medical, Inc.Inventors: Marcy R. Makarewicz, Mutua Mattu, Thomas B. Blank, Stephen L. Monfre, Timothy L. Ruchti