Abstract: Smart fertilizers and method of using and manufacturing are provided that include nanocarbon solution mixed with nanocomposite hydrogels at predetermined percentage weight or volume ratio (% w/w or % v/v). The resulted smart fertilizers are characterized in biosensors for detecting electricity conductance (EC) and/or pH degree of the surrounding soil caused by the release of ATPase H+ from the plant roots and in bioactuators for chemically reacting with the surrounding hydron ions to release the nutrients once the biodetectors detect the stimuli conditions.

Abstract: An automated package delivery machine, comprising: a housing with auto-lock doors; carousels; and robotic assemblies. The housing may substantially enclose the carousels and the robotic assemblies, and substantially prevents unwanted access to an interior of the housing. Each carousel may comprise a plurality of storage containers, a drive belt, a motor, and one or more rails. The storage containers may each have a plurality of slots, which are configured to accept and contain one or more packages to be delivered to one or more customers. The rails may form a loop track to which the storage containers are slidably engaged. The drive belt, driven by said motor, is configured to slidingly move the storage containers along the rails. The robotic assemblies are configured to remove the packages from the slots and deliver them to an interior side of the auto-lock doors.

Abstract: Described herein are carboxamide derivatives that are useful as inhibitors of p90 ribosomal S6 kinase (RSK), pharmaceutical compositions comprising the derivatives, and methods of using the derivatives in treating diseases or conditions associated with RSK activity.

Abstract: Described herein are carboxamide derivatives that are useful as inhibitors of p90 ribosomal S6 kinase (RSK), pharmaceutical compositions comprising the derivatives, and methods of using the derivatives in treating diseases or conditions associated with RSK activity. Such carboxamide derivatives form bicyclic and tricyclic ring systems and the disease or condition associated with RSK activity in a mammal is cancer.

Abstract: Described herein are carboxamide derivatives that are useful as inhibitors of p90 ribosomal S6 kinase (RSK), pharmaceutical compositions comprising the derivatives, and methods of using the derivatives in treating diseases or conditions associated with RSK activity. Such carboxamide derivatives form bicyclic and tricyclic ring systems and the disease or condition associated with RSK activity in a mammal is cancer.

Abstract: Described herein are carboxamide derivatives of Formula (II) that are useful as inhibitors of p90 ribosomal S6 kinase (RSK), pharmaceutical compositions comprising the derivatives, and methods of using the derivatives in treating diseases or conditions associated with RSK activity: wherein R2, R4a, R4b, R11, R12, and n are defined in the specification.

Abstract: Described herein are carboxamide derivatives that are useful as inhibitors of p90 ribosomal S6 kinase (RSK), pharmaceutical compositions comprising the derivatives, and methods of using the derivatives in treating diseases or conditions associated with RSK activity.

Abstract: Described herein are carboxamide derivatives of Formula (II) that are useful as inhibitors of p90 ribosomal S6 kinase (RSK), pharmaceutical compositions comprising the derivatives, and methods of using the derivatives in treating diseases or conditions associated with RSK activity: wherein R2, R4a, R4b, R11, R12, and n are defined in the specification.

Abstract: Described herein are carboxamide derivatives that are useful as inhibitors of p90 ribosomal S6 kinase (RSK), pharmaceutical compositions comprising the derivatives, and methods of using the derivatives in treating diseases or conditions associated with RSK activity.

Abstract: Lead-free primary explosives of the formula (cat)Y[MII(T)X(H2O)6-X]Z, where T is 5-nitrotetrazolate, and syntheses thereof are described. Substantially stoichiometric equivalents of the reactants lead to high yields of pure compositions thereby avoiding dangerous purification steps.

Abstract: High surface area monolithic foams of essentially pure metal were prepared. Salts of the corresponding metal were prepared as loose powders, pressed into shapes, ignited under an inert atmosphere, and then heated under an atmosphere containing hydrogen to form nanostructured metal foam monoliths of essentially pure metal having a very high surface area.

Abstract: The present invention provides a compound of the formula (Cat)+z[M++(5-nitro-1H-tetrazolato-N2)?x(H2O)y] where x is 3 or 4, y is 2 or 3, x+y is 6, z is 1 or 2, and M++ is selected from the group consisting of iron, cobalt, nickel, copper, zinc, chromium, and manganese, and (Cat)+ is selected from the group consisting of ammonium, sodium, potassium, rubidium and cesium. A method of preparing the compound of that formula is also disclosed.