Patents by Inventor Myrna E. Trumbauer

Myrna E. Trumbauer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Transgenic mouse expressing a familial form of human amyloid precursor protein
    Patent number: 6211428
    Abstract: Transgenic non-human mammals which express in their brains a nucleic acid construct comprising a DNA sequence encoding a human amyloid precursor protein FAD variant where at amino acid position 717 valine is substituted by isoleucine. These transgenic non-human mammals can be assays systems for determining compounds which are effective in modulating production of human amyloid precursor protein in brain and in isolated neuronal cells. Specifically exemplified are transgenic mice whose genome comprises a DNA sequence encoding a human amyloid precursor protein FAD variant where at amino acid position 717 valine is substituted by isoleucine operably linked to a Thy-1 promoter. The mice are shown to produce the APP-FAD variant in their brains by mRNA and protein assays.
    Type: Grant
    Filed: April 28, 1997
    Date of Patent: April 3, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Gurparlash Singh, Howard Y. Chen, Robert P. Heavens, Dalip J. S. Sirinathsinghji, David W. Smith, Myrna E. Trumbauer, Leonardus H. T. Van Der Ploeg, Aurawan Vongs, Hui Zheng
  • Transgenic mouse having a disrupted amyloid precursor protein gene
    Patent number: 6187992
    Abstract: The present invention relates to a transgenic nonhuman animal lacking native amyloid precursor protein. The transgenic mouse of the invention may be used in the study of Alzheimer's Disease and disorders involving the central nervous system.
    Type: Grant
    Filed: March 11, 1999
    Date of Patent: February 13, 2001
    Assignees: Merck & co., Inc., Merck Frosst Canada & Co.
    Inventors: Hui Zheng, Howard Y. Chen, Myrna E. Trumbauer, Leonardus H. T. van der Ploeg, Guy Seabrook, Dalip Sirinathsinghji
  • Expression of human interleukin-1.beta. in a transgenic animal
    Patent number: 5824837
    Abstract: A transgenic mouse has been prepared that expresses a human interluekin-1.beta. transgene. Expression of the transgene is mediated by a mouse metallothionein promoter. As a result of the expression of this transgene, the mouse has inflammation of its kidney and liver. The claimed animals are useful as screening tools for agents that are potentially useful for treating inflammation.
    Type: Grant
    Filed: April 22, 1996
    Date of Patent: October 20, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Howard Y. Chen, Kathryn J. Hofmann, Leonardus H. T. Van Der Ploeg, Alan R. Shaw, Myrna E. Trumbauer, Hui Zheng
  • Bradykinin B2 receptor modified transgenic non-human animals
    Patent number: 5750826
    Abstract: A transgenic non-human animal with alterations in a bradykinin B2 receptor gene is prepared by introduction of a gene encoding an altered bradykinin B2 receptor into a host non-human animal.
    Type: Grant
    Filed: December 2, 1996
    Date of Patent: May 12, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Joseph A. Borkowski, Howard Y. Chen, John W. Hess, Catherine D. Strader, Myrna E. Trumbauer