Patents by Inventor Nadine Honore

Nadine Honore has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant BCG expressing antigens of the ESX-1 secretion system
    Patent number: 10010597
    Abstract: Recombinant strains of Mycobacterium bovis bacille Calmette-Guerin (M. bovis BCG) comprising a heterologous nucleic acid sequence of Mycobacterium marinum (M. marinum) are provided. In some embodiments the heterologous nucleic acid sequence of M. marinum comprises a plurality of open reading frames, wherein the plurality of open reading frames comprise open reading frames that encode proteins each at least 95% homologous to the Mycobacterium marinum (M. marinum) proteins MMAR5445, MMAR5446, MMAR5447, MMAR5448, MMAR5449, MMAR5450, MMAR5451, MMAR5452, MMAR5453, and MMAR5455. In some embodiments the plurality of open reading frames further comprise an open reading frame that encodes a protein at least 95% homologous to the M. marinum proteins MMAR5443, MMAR5444, and MMAR5457. In some embodiments the plurality of open reading frames further comprise open reading frames that encode proteins at least 95% homologous to the M.
    Type: Grant
    Filed: June 3, 2015
    Date of Patent: July 3, 2018
    Assignee: INSTITUT PASTEUR
    Inventors: Roland Brosch, Laleh Majlessi, Nadine Honore, Matthias Groschel, Fadel Sayes, Roxane Simeone
  • RECOMBINANT MYCOBACTERIUM BOVIS BCG EXPRESSING ANTIGENS OF THE MYCOBACTERIUM MARINUM ESX-1 SECRETION SYSTEM
    Publication number: 20170106073
    Abstract: Recombinant strains of Mycobacterium bovis bacille Calmette-Guerin (M. bovis BCG) comprising a heterologous nucleic acid sequence of Mycobacterium marinum (M. marinum) are provided. In some embodiments the heterologous nucleic acid sequence of M. marinum comprises a plurality of open reading frames, wherein the plurality of open reading frames comprise open reading frames that encode proteins each at least 95% homologous to the Mycobacterium marinum (M. marinum) proteins MMAR5445, MMAR5446, MMAR5447, MMAR5448, MMAR5449, MMAR5450, MMAR5451, MMAR5452, MMAR5453, and MMAR5455. In some embodiments the plurality of open reading frames further comprise an open reading frame that encodes a protein at least 95% homologous to the M. marinum proteins MMAR5443, MMAR5444, and MMAR5457. In some embodiments the plurality of open reading frames further comprise open reading frames that encode proteins at least 95% homologous to the M.
    Type: Application
    Filed: June 3, 2015
    Publication date: April 20, 2017
    Inventors: Roland BROSCH, Laleh MAJLESSI, Nadine HONORE, Matthias GROSCHEL, Fadel SAYES, Roxane SIMEONE
  • Rapid detection of antibiotic resistance in mycobacterium tuberculosis
    Patent number: 6124098
    Abstract: A nucleotide sequence encoding a katG/lacZ fusion protein is useful for assaying the enzymatic activity of the katG gene product. A process of selecting a compound that is toxic against an isoniazid-resistant mycobaterial strain comprises incubating a catalase peroxidase enzyme with an isoniazid to produce a compound that restores isoniazid susceptability to the isoniazid-resistant mycobaterial strain.
    Type: Grant
    Filed: May 20, 1998
    Date of Patent: September 26, 2000
    Assignees: Institut Pasteur, Medical Research Council, Assistance Publique, Universite Pierre et Marie Curie (Paris VI), Universite de Berne
    Inventors: Beate Heym, Stewart Cole, Douglas Young, Ying Zhang, Nadine Honore, Amalio Telenti, Thomas Bodmer
  • DNA sequences of the papillomavirus HPV42 for use in diagnosis
    Patent number: 5952487
    Abstract: DNA sequences derived from human papillomavirus HPV42 are disclosed. Also disclosed are methods of using these sequences as hybridization probes in diagnostic assays.
    Type: Grant
    Filed: February 10, 1994
    Date of Patent: September 14, 1999
    Assignee: Institut Pasteur
    Inventors: Wolfgang Philipp, Martin Sapp, Stewart Cole, Nadine Honore
  • Rapid detection of antibiotic resistance in mycobacterium tuberculosis
    Patent number: 5851763
    Abstract: A process for the detection of resistance to an antibiotic in a mycobacterium comprises detecting a mutation in a gene selected from the group consisting of the katG gene or fragment thereof, the rpoB gene or fragment thereof, and the rpsI gene or fragment thereof. The process is useful for detecting in vitro the presence of nucleic acids of a Mycobacterium tuberculosis resistant to isoniazid.
    Type: Grant
    Filed: October 12, 1994
    Date of Patent: December 22, 1998
    Assignee: Institut Pasteur
    Inventors: Beate Heym, Stewart Cole, Douglas Young, Ying Zhang, Nadine Honore, Amalio Telenti, Thomas Bodmer