Patents by Inventor Nadine Nassif
Nadine Nassif has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11654212Abstract: Disclosed is the preparation of injectable collagen suspensions, to the method for preparing the suspensions, and to the uses thereof, particularly for forming dense collagen matrices.Type: GrantFiled: March 17, 2016Date of Patent: May 23, 2023Assignees: UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Nadine Nassif, Francisco Miguel Moreira Martins Fernandes, Cedric Boissiere, Clement Sanchez, Marie-Madeleine Giraud-Guille
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Publication number: 20180177915Abstract: Disclosed is a method for preparing a transparent fibrillated collagen matrix capable of being used as a tissue substitute in the production of a tissue or an artificial organ, in particular for a cornea substitute.Type: ApplicationFiled: June 17, 2016Publication date: June 28, 2018Inventors: Nadine NASSIF, Marie-Madeleine GIRAUD-GUILLE, Yan WANG, Marc ROBIN, Flore SALVIAT
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Publication number: 20180071430Abstract: Disclosed is the preparation of injectable collagen suspensions, to the method for preparing the suspensions, and to the uses thereof, particularly for forming dense collagen matrices.Type: ApplicationFiled: March 17, 2016Publication date: March 15, 2018Inventors: Nadine NASSIF, Francisco Miguel MOREIRA MARTINS FERNANDES, Cedric BOISSIERE, Clement SANCHEZ, Marie-Madeleine GIRAUD-GUILLE
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Patent number: 9884139Abstract: A method for preparing a synthetic material having an organic phase and a mineral phase which consists in preparing an initial acidic aqueous solution of collagen which is a precursor for the organic phase (I), and at least one aqueous solution of precursors for the mineral phase (II), and in precipitating the collagen by increasing the pH to a value of at least 7. The method includes the concentration of collagen in the acidic aqueous solution is at least 75 mg/ml and remains constant during said increase in pH. The mineral phase precursors have at least one calcium salt and at least one phosphate salt. The precipitation of the mineral phase (II) is carried out by bringing the mineral phase precursor solution into contact with the organic phase (I), the bringing into contact being carried out before or after the precipitation of the organic phase (I).Type: GrantFiled: September 10, 2014Date of Patent: February 6, 2018Assignees: UNIVERSITE PIERRE ET MARIE CURIE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFICInventors: Nadine Nassif, Frederic Gobeaux, Marie-Madeleine Giraud-Guille, Gervaise Mosser
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Patent number: 9867902Abstract: Method for preparing a homogeneous collagen-based material by concentration of a collagen solution, includes bringing a collagen solution into contact by way of continuous injection and use of the material for tissue repair.Type: GrantFiled: May 30, 2011Date of Patent: January 16, 2018Assignees: UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE VERSAILLES SAINT QUENTIN EN YVELINESInventors: Marie-Madeleine Giraud-Guille, Nadine Nassif, Yan Wang, Christophe Helary, Anne Pelle
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Publication number: 20160361469Abstract: A method for preparing a synthetic material having an organic phase and a mineral phase which consists in preparing an initial acidic aqueous solution of collagen which is a precursor for the organic phase (I), and at least one aqueous solution of precursors for the mineral phase (II), and in precipitating the collagen by increasing the pH to a value of at least 7. The method includes the concentration of collagen in the acidic aqueous solution is at least 75 mg/ml and remains constant during said increase in pH. The mineral phase precursors have at least one calcium salt and at least one phosphate salt. The precipitation of the mineral phase (II) is carried out by bringing the mineral phase precursor solution into contact with the organic phase (I), the bringing into contact being carried out before or after the precipitation of the organic phase (I).Type: ApplicationFiled: September 10, 2014Publication date: December 15, 2016Inventors: Nadine Nassif, Frederic Gobeaux, Marie-Madeleine Giraud-Guille, Gervaise Mosser
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Patent number: 8859008Abstract: The invention relates to a material that can be used as a bone substitute and to a method for the preparation thereof. The material comprises an organic phase (I) comprising striated collagen fibrils constituted of collagen I triple helices, said fibrils being organized over a large distance according to a 3D geometry associating aligned domains and cholesteric domains, and also isotropic domains where they are not organized; and a mineral phase (II) comprising apatite crystals having a hexagonal crystalline structure, space group 6/m, comprising at least calcium ions and phosphate ions; the axis c of said apatite crystals of the mineral phase is coaligned with the longitudinal axis of the striated collagen fibrils of the organic phase and the collagen content in the material is at least 75 mg/cm3.Type: GrantFiled: June 26, 2009Date of Patent: October 14, 2014Assignees: Universite Pierre et Marie Curie, Centre National de la Recherche Scientifique, Ecole Pratique des Hautes EtudesInventors: Nadine Nassif, Frédéric Gobeaux, Marie-Madeleine Giraud Guille, Gervaise Mosser
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Publication number: 20130142840Abstract: Method for preparing a homogeneous collagen-based material by concentration of a collagen solution, includes bringing a collagen solution into contact by way of continuous injection and use of the material for tissue repair.Type: ApplicationFiled: May 30, 2011Publication date: June 6, 2013Applicants: UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), UNIVERSITE DE VERSAILLES SAINT QUENTIN EN YVELINES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Marie-Madeleine Giraud-Guille, Nadine Nassif, Yan Wang, Christophe Helary, Anne Pelle
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Publication number: 20120076870Abstract: The invention relates to a material that can be used as a bone substitute and to a method for the preparation thereof. The material comprises an organic phase (I) comprising striated collagen fibrils constituted of collagen I triple helices, said fibrils being organized over a large distance according to a 3D geometry associating aligned domains and cholesteric domains, and also isotropic domains where they are not organized; and a mineral phase (II) comprising apatite crystals having a hexagonal crystalline structure, space group 6/m, comprising at least calcium ions and phosphate ions; the axis c of said apatite crystals of the mineral phase is coaligned with the longitudinal axis of the striated collagen fibrils of the organic phase and the collagen content in the material is at least 75 mg/cm3.Type: ApplicationFiled: June 26, 2009Publication date: March 29, 2012Inventors: Nadine Nassif, Frédéric Gobeaux, Marie-Madeleine Giraud Guille, Gervaise Mosser
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Publication number: 20110250289Abstract: The invention relates to a material that can be used as a bone substitute and to a method for the preparation thereof. The material comprises an organic phase (I) comprising striated collagen fibrils constituted of collagen I triple helices, said fibrils being organized over a large distance according to a 3D geometry associating aligned domains and cholesteric domains, and also isotropic domains where they are not organized; and a mineral phase (II) comprising apatite crystals having a hexagonal crystalline structure, space group 6/m, comprising at least calcium ions and phosphate ions; the axis c of said apatite crystals of the mineral phase is coaligned with the longitudinal axis of the striated collagen fibrils of the organic phase and the collagen content in the material is at least 75 mg/cm3.Type: ApplicationFiled: June 26, 2009Publication date: October 13, 2011Inventors: Nadine Nassif, Frédéric Gobeaux, Marie-Madeleine Giraud Guille, Gervaise Mosser
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Patent number: 7902343Abstract: Methods and kits are disclosed for use in the analysis of microsatellite instability in genomic DNA. Methods and kits are also disclosed which can be used to detect microsatellite instability DNA present in biological materials, such as tumors. The methods and kits of the present invention can be used to detect or diagnose diseases associated with microsatellite instability, such as certain types of cancer.Type: GrantFiled: April 25, 2008Date of Patent: March 8, 2011Assignee: Promega CorporationInventors: Jeffery W. Bacher, Laura Flanagan, Nadine Nassif
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Patent number: 7749706Abstract: Methods and kits are disclosed for use in the analysis of microsatellite instability in genomic DNA. Methods and kits are also disclosed which can be used to detect microsatellite instability DNA present in biological materials, such as tumors. The methods and kits of the present invention can be used to detect or diagnose diseases associated with microsatellite instability, such as certain types of cancer.Type: GrantFiled: December 19, 2006Date of Patent: July 6, 2010Assignee: Promega CorporationInventors: Jeffrey W. Bacher, Laura Flanagan, Nadine Nassif
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Publication number: 20090061438Abstract: Methods and kits are disclosed for use in the analysis of microsatellite instability in genomic DNA. Methods and kits are also disclosed which can be used to detect microsatellite instability DNA present in biological materials, such as tumors. The methods and kits of the present invention can be used to detect or diagnose diseases associated with microsatellite instability, such as certain types of cancer.Type: ApplicationFiled: April 25, 2008Publication date: March 5, 2009Applicant: Promega CorporationInventors: Jeffery W. Bacher, Laura Flanagan, Nadine Nassif
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Patent number: 7364853Abstract: Methods and kits are disclosed for use in the analysis of microsatellite instability in genomic DNA. Methods and kits are also disclosed which can be used to detect microsatellite instability DNA present in biological materials, such as tumors. The methods and kits of the present invention can be used to detect or diagnose diseases associated with microsatellite instability, such as certain types of cancer.Type: GrantFiled: January 18, 2005Date of Patent: April 29, 2008Assignee: Promega CorporationInventors: Jeffery W. Bacher, Laura Flanagan, Nadine Nassif
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Publication number: 20070117136Abstract: Methods and kits are disclosed for use in the analysis of microsatellite instability in genomic DNA. Methods and kits are also disclosed which can be used to detect microsatellite instability DNA present in biological materials, such as tumors. The methods and kits of the present invention can be used to detect or diagnose diseases associated with microsatellite instability, such as certain types of cancer.Type: ApplicationFiled: December 19, 2006Publication date: May 24, 2007Applicant: PROMEGA CORPORATIONInventors: Jeffery Bacher, Laura Flanagan, Nadine Nassif
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Patent number: 7202031Abstract: Methods and kits are disclosed for use in the analysis of microsatellite instability in genomic DNA. Methods and kits are also disclosed which can be used to detect microsatellite instability DNA present in biological materials, such as tumors. The methods and kits of the present invention can be used to detect or diagnose diseases associated with microsatellite instability, such as certain types of cancer.Type: GrantFiled: December 9, 2002Date of Patent: April 10, 2007Assignee: Promega CorporationInventors: Jeffery W. Bacher, Laura Flanagan, Nadine Nassif
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Publication number: 20050202473Abstract: Methods and kits are disclosed for use in the analysis of microsatellite instability in genomic DNA. Methods and kits are also disclosed which can be used to detect microsatellite instability DNA present in biological materials, such as tumors. The methods and kits of the present invention can be used to detect or diagnose diseases associated with microsatellite instability, such as certain types of cancer.Type: ApplicationFiled: January 18, 2005Publication date: September 15, 2005Applicant: Promega CorporationInventors: Jeffery Bacher, Laura Flanagan, Nadine Nassif
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Patent number: 6844152Abstract: Methods and kits are disclosed for use in the analysis of microsatellite instability in genomic DNA. Methods and kits are also disclosed which can be used to detect microsatellite instability DNA present in biological materials, such as tumors. The methods and kits of the present invention can be used to detect or diagnose diseases associated with microsatellite instability, such as certain types of cancer.Type: GrantFiled: September 15, 2000Date of Patent: January 18, 2005Assignee: Promega CorporationInventors: Jeffery W. Bacher, Laura Flanagan, Nadine Nassif
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Publication number: 20030180758Abstract: Methods and kits are disclosed for use in the analysis of microsatellite instability in genomic DNA. Methods and kits are also disclosed which can be used to detect microsatellite instability DNA present in biological materials, such as tumors. The methods and kits of the present invention can be used to detect or diagnose diseases associated with microsatellite instability, such as certain types of cancer.Type: ApplicationFiled: December 9, 2002Publication date: September 25, 2003Applicant: Promega CorporationInventors: Jeffery W. Bacher, Laura Flanagan, Nadine Nassif
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Publication number: 20020058265Abstract: Methods and kits are disclosed for use in the analysis of microsatellite instability in genomic DNA. Methods and kits are also disclosed which can be used to detect microsatellite instability DNA present in biological materials, such as tumors. The methods and kits of the present invention can be used to detect or diagnose diseases associated with microsatellite instability, such as certain types of cancer.Type: ApplicationFiled: April 24, 2001Publication date: May 16, 2002Applicant: Promega CorporationInventors: Jeffery W. Bacher, Laura Flanagan, Nadine Nassif