Patents by Inventor Nai-Hong Li
Nai-Hong Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20120309851Abstract: The present invention relates to methods for removing residual surface material from porous polymerized particle surfaces. The particles thus produced have an increase in surface porosity and uniformity in a variety of applications. Desirably, substantially the entire surface communicates with the interior of the particles. Also provided are the particles produced by such methods, further modifications of such particles, and methods for using the particles in a variety of applications. All described methods, compositions, and articles of manufacture are within the scope of the invention.Type: ApplicationFiled: May 4, 2010Publication date: December 6, 2012Inventors: Nai-Hong Li, Yuchiong Hsuanyu, James R. Benson, Marc Freed
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Publication number: 20110091512Abstract: The present invention relates to porous cross-linked polymeric particles having cavities joined by interconnecting pores wherein all or nearly all of the cavities at the interior of each particle communicate with the surface of the particle. The present invention also relates to a process for producing a porous, cross-linked large polymeric particle as well as the product of this process. This process involves combining a continuous phase with an aqueous discontinuous phase to form an emulsion, then placing this emulsion into a mold to produce large particles having shapes derived from a mold, e.g., ellipsoids, spheroids, cylinders, prisms, etc. Also included in the invention are modifications of the particles as well as methods for using the particles in a variety of applications. All described methods, compositions, and articles of manufacture are within the scope of the invention.Type: ApplicationFiled: September 5, 2008Publication date: April 21, 2011Applicant: SUNSTORM RESEARCH CORPORATIONInventor: Nai-Hong LI
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Patent number: 6750303Abstract: Functional polymers containing hydroxyl groups as supports for use with catalysts can increase the activity of these catalysts which results in improved ethylene polymerization. The present invention seeks to provide catalysts with improved activity by incorporating 2-hydroxyethyl methacrylate (HEMA) into the support of the catalyst.Type: GrantFiled: April 30, 2003Date of Patent: June 15, 2004Assignee: The Governors of the University of AlbertaInventors: Peter Phung Minh Hoang, Charles Russell, Jason Roy Kearns, Sieghard E. Wanke, David T. Lynch, Nai-Hong Li
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Publication number: 20030199389Abstract: Functional polymers containing hydroxyl groups as supports for use with catalysts can increase the activity of these catalysts which results in improved ethylene polymerization. The present invention seeks to provide catalysts with improved activity by incorporating 2-hydroxyethyl methacrylate (HEMA) into the support of the catalyst.Type: ApplicationFiled: April 30, 2003Publication date: October 23, 2003Applicant: THE GOVERNORS OF THE UNIVERSITY OF ALBERTAInventors: Peter Phung Minh Hoang, Charles Russell, Jason Roy Kearns, Sieghard E. Wanke, David T. Lynch, Nai-Hong Li
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Patent number: 6583082Abstract: Functional polymers containing hydroxyl groups as supports for use with catalysts can increase the activity of these catalysts which results in improved ethylene polymerization. The present invention seeks to provide catalysts with improved activity by incorporating 2-hydroxyethyl methacrylate (HEMA) into the support of the catalyst.Type: GrantFiled: December 1, 2000Date of Patent: June 24, 2003Assignee: The Governors of the University of AlbertaInventors: Peter Phung Minh Hoang, Charles Russell, Jason Roy Kearns, Sieghard E. Wanke, David T. Lynch, Nai-Hong Li
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Publication number: 20020103073Abstract: Functional polymers containing hydroxyl groups as supports for use with catalysts can increase the activity of these catalysts which results in improved ethylene polymerization. The present invention seeks to provide catalysts with improved activity by incorporating 2-hydroxyethyl methacrylate (HEMA) into the support of the catalyst.Type: ApplicationFiled: December 1, 2000Publication date: August 1, 2002Applicant: The Governors of the University of AlbertaInventors: Peter Phung Minh Hoang, Charles Russell, Jason Roy Kearns, Sieghard E. Wanke, David T. Lynch, Nai-Hong Li
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Patent number: 6291598Abstract: A polymerized material produced by the polymerization of an organic amide monomer in the presence of an organic carbonate and a process for the preparation thereof. The process comprises the steps of: heating an amount of the organic anide monomer to a temperature above its melting point; first mixing an amount of an anionic initiator with at least a portion of the amount of heated organic amide mnonomer to produce an amount of activated monomer, wherein the anionic initiator is not comprised of an alkali metal; second mixing an amount of the organic carbonate with at least a portion of the amount of heated organic amide monomer to produce an amount of dissolved organic carbonate; and polymerizing the amounts of heated organic amide monomer and activated monomer in the presence of the amount of dissolved organic carbonate to produce the polymerized material.Type: GrantFiled: October 18, 1999Date of Patent: September 18, 2001Inventors: Michael C. Williams, Nai-Hong Li, Yatin Sankholkar
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Patent number: 6100306Abstract: The present invention relates to porous crosslinked polymeric microbeads having cavities joined by interconnecting pores wherein at least some of the cavities at the interior of each microbead communicate with the surface of the microbead. The present invention also relates to a process for producing a porous, crosslinked polymeric microbead as well as the product of this process. This process involves combining an oil phase with an aqueous discontinuous phase to form an emulsion, adding the emulsion to an aqueous suspension medium to form an oil-in-water suspension of dispersed emulsion droplets, and polymerizing the emulsion droplets to form microbeads. At least 10% of the microbeads produced in accordance with the present invention are substantially spherical or substantially ellipsoidal or a combination of the two.Type: GrantFiled: October 2, 1998Date of Patent: August 8, 2000Assignee: Biopore CorporationInventors: Nai-Hong Li, James R. Benson, Naotaka Kitagawa
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Patent number: 5863957Abstract: The present invention relates to porous crosslinked polymeric microbeads having cavities joined by interconnecting pores wherein at least some of the cavities at the interior of each microbead communicate with the surface of the microbead. The present invention also relates to a process for producing a porous, crosslinked polymeric microbead as well as the product of this process. This process involves combining an oil phase with an aqueous discontinuous phase to form an emulsion, adding the emulsion to an aqueous suspension medium to form an oil-in-water suspension of dispersed emulsion droplets, and polymerizing the emulsion droplets to form microbeads. At least 10% of the microbeads produced in accordance with the present invention are substantially spherical or substantially ellipsoidal or a combination of the two.Type: GrantFiled: June 27, 1996Date of Patent: January 26, 1999Assignee: Biopore CorporationInventors: Nai-Hong Li, James R. Benson, Naotaka Kitagawa
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Patent number: 5760097Abstract: The present invention relates to porous crosslinked polymeric microbeads having cavities joined by interconnecting pores wherein at least some of the cavities at the interior of each microbead communicate with the surface of the microbead. The present invention also relates to a process for producing a porous, crosslinked polymeric microbead as well as the product of this process. This process involves combining an oil phase with an aqueous discontinuous phase to form an emulsion, adding the emulsion to an aqueous suspension medium to form an oil-in-water suspension of dispersed emulsion droplets, and polymerizing the emulsion droplets to form microbeads. At least 10% of the microbeads produced in accordance with the present invention are substantially spherical or substantially ellipsoidal or a combination of the two.Type: GrantFiled: April 10, 1996Date of Patent: June 2, 1998Assignee: Biopore CorporationInventors: Nai-Hong Li, James R. Benson, Naotaka Kitagawa
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Patent number: 5653922Abstract: The present invention relates to porous crosslinked polymeric microbeads having cavities joined by interconnecting pores wherein at least some of the cavities at the interior of each microbead communicate with the surface of the microbead. The present invention also relates to a process for producing a porous, crosslinked polymeric microbead as well as the product of this process. This process involves combining an oil phase with an aqueous discontinuous phase to form an emulsion, adding the emulsion to an aqueous suspension medium to form an oil-in-water suspension of dispersed emulsion droplets, and polymerizing the emulsion droplets to form microbeads. At least 10% of the microbeads produced in accordance with the present invention are substantially spherical or substantially ellipsoidal or a combination of the two.Type: GrantFiled: June 7, 1995Date of Patent: August 5, 1997Assignee: Biopore CorporationInventors: Nai-Hong Li, James R. Benson, Naotaka Kitagawa
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Patent number: 5583162Abstract: The present invention relates to porous crosslinked polymeric microbeads having cavities joined by interconnecting pores wherein at least some of the cavities at the interior of each microbead communicate with the surface of the microbead. Approximately 10% of the microbeads of the present invention are substantially spherical or substantially ellipsoid or a combination of the two. The present invention also relates to a process for producing a porous, crosslinked polymeric microbead as well as the product of this process. This process involves combining a continuous phase with an aqueous discontinuous phase to form an emulsion, adding the emulsion to an aqueous suspension medium to form an oil-in-water suspension of dispersed emulsion droplets, and polymerizing the emulsion droplets to form microbeads. Also included in the invention are modifications of the microbeads as well as methods for using the microbeads in a variety of applications.Type: GrantFiled: June 6, 1994Date of Patent: December 10, 1996Assignee: Biopore CorporationInventors: Nai-Hong Li, James R. Benson
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Patent number: 5288763Abstract: Porous, polymer particles comprising a functionalized cross-linked copolymer having microporous regions and macroporous regions in the polymer matrix thereof, wherein the functional groups are essentially present only within the macroporous regions, as well as processes for preparing these particles based on a template polymerization technique followed by removal of the template polymer from the particles are disclosed. The particles of the invention are useful in chromatography, and in various analytical, diagnostic techniques and solid state peptide, DNA synthesis.Type: GrantFiled: December 23, 1992Date of Patent: February 22, 1994Assignee: The Johns Hopkins University School of MedicineInventors: Nai-Hong Li, Kam W. Leong
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Patent number: 5168104Abstract: A method to prepare uniform populations of macroscopic beads containing pores of at least 0.1 microns diameter is described. The beads consist essentially of a copolymer of a monoethylenically unsaturated monomer and a crosslinking polyethylenically unsaturated monomer, said resulting copolymer optionally being derivatized with functional groups, linking moieties, and/or affinity ligands. The macroporous beads are obtained by utilizing, as porogen in the polymerization reaction, porous inorganic particles which have been preabsorbed with a blowing agent. The blowing agent is not activated until after the polymerization takes place; when the blowing agent is activated, the organic polymer which isolates the inorganic porogen particles from each other in the bead is destroyed. Upon subsequent dissolution of the inorganic porogen, a network of pores throughout the organic copolymer-formed particle is formed. The resulting beads are useful in a variety of chromatographic, analytical and biomedical techniques.Type: GrantFiled: September 13, 1991Date of Patent: December 1, 1992Assignee: Chembiomed, Ltd.Inventors: Nai-Hong Li, M. Abdul Mazid
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Patent number: 5047438Abstract: Porous, rigid resin particles are prepared having a predetermined particle size distribution, surface area and porosity by polymerizing in the pores of porous inorganic template particles a reaction mixture comprising monovinyl monomers, polyvinyl crosslinking monomers and a polymerization initiator in a liquid medium in which the monomers and initiator are phase separable and extractable therefrom into the pores of the template particles. The extracted mixture is polymerized in the pores of the template particles, and the template particles are removed without destruction of the polymerizate. The isolated polymerizate mirrors the characteristics of the template particles. The surface of the polymerizate may be modified in various ways to contain desired functionality. The particles of the invention are useful in chromatography, adsorption, ion exchange, and in catalysis.Type: GrantFiled: September 26, 1988Date of Patent: September 10, 1991Assignee: Supelco, Inc.Inventors: Binyamin Feibush, Nai-Hong Li
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Patent number: 4933372Abstract: Porous, rigid resin particles are prepared having a predetermined particle size distribution, surface area and porosity by polymerizing in the pores of porous inorganic template particles a reaction mixture comprising monovinyl monomers, polyvinyl crosslinking monomers and a polymerization initiator in a liquid medium in which the monomers and initiator are phase separable and extractable therefrom into the pores of the template particles. The extracted mixture is polymerized in the pores of the template particles, and the template particles are removed without destruction of the polymerizate. The isolated polymerizate mirrors the characteristics of the template particles. The surface of the polymerizate may be modified in various ways to contain desired functionality. The particles of the invention are useful in chromatography, adsorption, ion exchange, and in catalysis.Type: GrantFiled: November 7, 1989Date of Patent: June 12, 1990Assignee: Supelco, Inc.Inventors: Binyamin Feibush, Nai-Hong Li