Patents by Inventor Naibo Yang

Naibo Yang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NUCLEIC ACID SEQUENCING USING AFFINITY REAGENTS
    Publication number: 20240117425
    Abstract: The invention provides compositions and methods for sequencing nucleic acids and other applications. In sequencing by synthesis, unlabeled reversible terminators are incorporated by a polymerase in each cycle, then labeled after incorporation by binding to the reversible terminator a directly or indirectly labeled antibody or other affinity reagent.
    Type: Application
    Filed: September 7, 2023
    Publication date: April 11, 2024
    Inventors: Radoje Drmanac, Snezana Drmanac, Handong Li, Xun Xu, Matthew J. Callow, Leon Eckhardt, Naibo Yang
  • Nucleic acid sequencing using affinity reagents
    Patent number: 11788138
    Abstract: The invention provides compositions and methods for sequencing nucleic acids and other applications. In sequencing by synthesis, unlabeled reversible terminators are incorporated by a polymerase in each cycle, then labeled after incorporation by binding to the reversible terminator a directly or indirectly labeled antibody or other affinity reagent.
    Type: Grant
    Filed: October 29, 2020
    Date of Patent: October 17, 2023
    Assignees: MGI Tech Co., Ltd., BGI Shenzhen
    Inventors: Radoje Drmanac, Snezana Drmanac, Handong Li, Xun Xu, Matthew J. Callow, Leon Eckhardt, Naibo Yang
  • Col14A1-derived tumor antigen polypeptide and use thereof
    Patent number: 11612643
    Abstract: Provided are a tumour antigen polypeptide having the amino acid sequence as shown in SEQ ID NO: 2 or a variant thereof; a nucleic acid encoding same; a nucleic acid construct, an expression vector, and a host cell comprising the encoding nucleic acid; and an antigen presenting cell presenting the tumour antigen polypeptide on the cell surface and an immune effector cell thereof. Also provided is the use of the polypeptide, nucleic acid, antigen presenting cell or immune effector cell in the diagnosis, prevention and treatment of cancers.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: March 28, 2023
    Assignee: GENOIMMUNE THERAPEUTICS CO, , LTD.
    Inventors: Bo Li, Geng Liu, Si Qiu, Dongli Li, Chongming Jiang, Shuntao Luo, Xiumei Lin, Ting An, Yong Hou, Chengchi Chao, Zhen Cheng, Handong Li, Naibo Yang
  • NANOBODY FOR PCSK9 AND APPLICATION THEREOF
    Publication number: 20230091895
    Abstract: Disclosed is an antibody capable of specifically recognizing PCSK9 or an antigen-binding fragment thereof. The antibody comprises heavy chain variable region CDR1, CDR2, and CDR3 sequences shown in SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3 or shown in amino acid sequences having at least 95% identity to SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3. The antibody can specifically bind to PCSK9 and inhibit the activity of PCSK9.
    Type: Application
    Filed: August 9, 2022
    Publication date: March 23, 2023
    Applicant: BGI SHENZHEN
    Inventors: Naibo Yang, Xiaoyan Gao, Xinyang Li, Xinhua Zhang, Meiniang Wang
  • CACNA1H-derived tumor antigen polypeptide and use thereof
    Patent number: 11548925
    Abstract: Provided are a tumor antigen polypeptide having the amino acid sequence as shown in SEQ ID NO: 2 or a variant thereof; a nucleic acid encoding the same; a nucleic acid construct, an expression vector, and a host cell containing the encoding nucleic acid; and an antigen presenting cell presenting the tumor antigen polypeptide on the cell surface and an immune effector cell thereof. Also provided is the use of the polypeptide, nucleic acid, antigen presenting cell or immune effector cell in the diagnosis, prevention and treatment of cancers.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: January 10, 2023
    Assignee: GENOIMMUNE THERAPEUTICS CO., LTD.
    Inventors: Guanglei Li, Yong Hou, Shuntao Luo, Xiumei Lin, Ting An, Bo Li, Wei Zhang, Chengchi Chao, Zhen Cheng, Handong Li, Naibo Yang
  • NUCLEIC ACID SEQUENCING USING AFFINITY REAGENTS
    Publication number: 20210254150
    Abstract: The invention provides compositions and methods for sequencing nucleic acids and other applications. In sequencing by synthesis, unlabeled reversible terminators are incorporated by a polymerase in each cycle, then labeled after incorporation by binding to the reversible terminator a directly or indirectly labeled antibody or other affinity reagent.
    Type: Application
    Filed: October 29, 2020
    Publication date: August 19, 2021
    Inventors: Radoje Drmanac, Snezana Drmanac, Handong Li, Xun Xu, Matthew J. Callow, Leon Eckhardt, Naibo Yang
  • Anti-BCMA single-chain antibody scFv and preparation method and application thereof
    Publication number: 20210246220
    Abstract: Provided are an anti-BCMA single-chain antibody scFv and a preparation method and application thereof. The preparation method is capable of artificially synthesizing a BCMA-targeted phage display library by combining site-directed mutagenesis and random mutagenesis technologies; and acquiring 3 new-type BCMA antigen-targeted scFv strains to serve as BCMA-targeted antibodies by combining a phage display technology.
    Type: Application
    Filed: October 10, 2018
    Publication date: August 12, 2021
    Inventors: Meiniang WANG, Bingjie OUYANG, Naibo YANG, Lin JIANG, Bingzhao REN, Yang LIU, Zhengqi ZHAO, Bo LI, Yong HOU, Fei WANG, Yuping GE, Xuan DONG
  • Method and system for screening nanobody
    Patent number: 10954550
    Abstract: Provided are a method for screening for nanobodies and a corresponding system. The method uses polymerase chain reactions and cDNA 5? end rapid amplification technology to screen for and obtain nanobodies. The experiment cycle requires only approximately 21 days.
    Type: Grant
    Filed: August 6, 2015
    Date of Patent: March 23, 2021
    Assignee: BGI SHENZHEN
    Inventors: Xiao Liu, Chao Nie, Wei Zhang, Zhe Ren, Ruifang Zhang, Xiaojing Zeng, Xinyang Li, Naibo Yang
  • Nucleic acid sequencing using affinity reagents
    Patent number: 10851410
    Abstract: The invention provides compositions and methods for sequencing nucleic acids and other applications. In sequencing by synthesis, unlabeled reversible terminators are incorporated by a polymerase in each cycle, then labeled after incorporation by binding to the reversible terminator a directly or indirectly labeled antibody or other affinity reagent.
    Type: Grant
    Filed: January 4, 2018
    Date of Patent: December 1, 2020
    Assignees: MGI Tech Co., Ltd., BGI Shenzhen
    Inventors: Radoje Drmanac, Snezana Drmanac, Handong Li, Xun Xu, Matthew J. Callow, Leon Eckhardt, Naibo Yang
  • CACNA1H-DERIVED TUMOR ANTIGEN POLYPEPTIDE AND USE THEREOF
    Publication number: 20200024316
    Abstract: Provided are a tumor antigen polypeptide having the amino acid sequence as shown in SEQ ID NO: 2 or a variant thereof; a nucleic acid encoding the same; a nucleic acid construct, an expression vector, and a host cell containing the encoding nucleic acid; and an antigen presenting cell presenting the tumor antigen polypeptide on the cell surface and an immune effector cell thereof. Also provided is the use of the polypeptide, nucleic acid, antigen presenting cell or immune effector cell in the diagnosis, prevention and treatment of cancers.
    Type: Application
    Filed: September 30, 2016
    Publication date: January 23, 2020
    Inventors: Guanglei LI, Yong HOU, Shuntao LUO, Xiumei LIN, Ting AN, Bo LI, Wei ZHANG, Chengchi CHAO, Zhen CHENG, Handong LI, Naibo YANG
  • COL14A1-DERIVED TUMOR ANTIGEN POLYPEPTIDE AND USE THEREOF
    Publication number: 20190224291
    Abstract: Provided are a tumour antigen polypeptide having the amino acid sequence as shown in SEQ ID NO: 2 or a variant thereof; a nucleic acid encoding same; a nucleic acid construct, an expression vector, and a host cell comprising the encoding nucleic acid; and an antigen presenting cell presenting the tumour antigen polypeptide on the cell surface and an immune effector cell thereof. Also provided is the use of the polypeptide, nucleic acid, antigen presenting cell or immune effector cell in the diagnosis, prevention and treatment of cancers.
    Type: Application
    Filed: September 30, 2016
    Publication date: July 25, 2019
    Inventors: Bo LI, Geng LIU, Si QIU, Dongli LI, Chongming JIANG, Shuntao LUO, Xiumei LIN, Ting AN, Yong HOU, Chengchi CHAO, Zhen CHENG, Handong LI, Naibo YANG
  • STEPWISE SEQUENCING BY NON-LABELED REVERSIBLE TERMINATORS OR NATURAL NUCLEOTIDES
    Publication number: 20180223358
    Abstract: The invention provides compositions and methods for sequencing nucleic acids and other applications. In sequencing by synthesis, unlabeled reversible terminators are incorporated by a polymerase in each cycle, then labeled after incorporation by binding to the reversible terminator a directly or indirectly labeled antibody or other affinity reagent.
    Type: Application
    Filed: January 4, 2018
    Publication date: August 9, 2018
    Inventors: Radoje Drmanac, Snezana Drmanac, Handong Li, Xun Xu, Matthew J. Callow, Leon Eckhardt, Naibo Yang, Quan Ding
  • Method and system for screening nanobody
    Publication number: 20170226566
    Abstract: Provided are a method for screening for nanobodies and a corresponding system. The method uses polymerase chain reactions and cDNA 5? end rapid amplification technology to screen for and obtain nanobodies. The experiment cycle requires only approximately 21 days.
    Type: Application
    Filed: August 6, 2015
    Publication date: August 10, 2017
    Inventors: Xiao Liu, Chao Nie, Wei Zhang, Zhe Ren, Ruifang Zhang, Xiaojing Zeng, Xinyang Li, Naibo Yang