Abstract: Disclosed are bifunctional targeted protein autophagy degraders that comprise: 1) a small-molecule targeting a protein of interest; 2) a linker; and 3) a small-molecule recruiter of the autophagy adapter LC3B. These degraders target specific proteins for degradation through the autophagy-lysosomal degradation pathway.

Abstract: A laser having an optical parametric oscillator for providing a preselected wavelength beam is provided. A nonlinear crystal cut for phase matching condition preferably cut for noncritical phase matching conditions for the fundamental beam wavelength and the preselected wavelength beam is located in both the optical parametric oscillator cavity and laser resonator cavity. The optical axis of the laser resonator and the optical axis of the optical parametric oscillator cavity are at least partially separate and partially overlap. The laser crystal is located in the laser resonator cavity but not in the optical parametric oscillator cavity. Each end of the OPO nonlinear crystal that intersects the optical axes has a Brewster cut for both the fundamental and preselected wavelength beams so that the fundamental and preselected wavelength beams incident on the nonlinear crystal at approximately the Brewster angle and pass through without substantial reflection loss.