Patents by Inventor Nancy Lau Liu Shen

Nancy Lau Liu Shen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stabilized enzyme compositions for nucleic acid amplification
    Patent number: 5834254
    Abstract: Stabilized enzyme compositions for use in nucleic acid amplification. Compositions are provided for the stabilization of one or more enzymes in a single stabilized formulation. Additional compositions incorporate a dried, stabilized enzyme mixture together with necessary cofactors and enzyme substrates in a single container for use upon rehydration. Also disclosed are methods for making and using stabilized enzyme compositions and kits for nucleic acid amplification incorporating the disclosed compositions.
    Type: Grant
    Filed: July 22, 1997
    Date of Patent: November 10, 1998
    Assignee: Gen-Probe Incorporated
    Inventors: Nancy Lau Liu Shen, Daniel Louis Kacian, James Garfield Putnam, William Michael Davis
  • Methods for determining pre-amplification levels of a nucleic acid target sequence from post-amplification levels of product
    Patent number: 5710029
    Abstract: Methods and kits for relating initial amounts of target nucleic acids present in a sample to target-specific amplification products. It has been discovered that the transcription-mediated amplification system is capable of producing a quantitative relationship between target input and target-specific output. Further, the present invention relates to methods for carefully controlling this relationship resulting in an unexpectedly high degree of reproducability. Also described are useful methods for extending the dynamic range of transcription-based amplification systems.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 20, 1998
    Assignee: Gen-Probe Incorporated
    Inventors: Thomas Brendan Ryder, Karen W. Shannon, Daniel Louis Kacian, Richard C. Harvey, Sherrol H. McDonough, Frank R. Gonzales, Maria R. Castillo, Elizabeth R. Billyard, Nancy Lau Liu Shen
  • Kits for determining pre-amplification levels of a nucleic acid target sequence from post-amplification levels of product
    Patent number: 5705365
    Abstract: Methods and kits for relating initial amounts of target nucleic acids present in a sample to target-specific amplification products. It has been discovered that the transcription-mediated amplification system is capable of producing a quantitative relationship between target input and target-specific output. Further, the the present invention relates to methods for carefully controlling this relationship resulting in an unexpectedly high degree of reproducability. Also described are useful methods for extending the dynamic range of transcription-based amplification systems.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 6, 1998
    Assignee: Gen-Probe Incorporated
    Inventors: Thomas Brendan Ryder, Karen W. Shannon, Daniel Louis Kacian, Richard C. Harvey, Sherrol H. McDonough, Frank R. Gonzales, Maria R. Castillo, Elizabeth R. Billyard, Nancy Lau Liu Shen