Abstract: The present invention relates to a melanin concentrating hormone antagonist compound of Formula I: (I) wherein Ar1, Ar2, Ar3, L1, L2 and Q areas defined, or a pharmaceutically acceptable salt, solvate, enantiomer or mixture of diastereomers thereof useful in the treatment, prevention or amelioration of symptoms associated with obesity and Related Diseases.

Abstract: The present invention relates to a melanin concentrating hormone antagonist compound of formula I: (I); or a pharmaceutically acceptable salt, solvate, enantiomer or prodrug thereof useful in the treatment, prevention or amelioration of symptoms associated with obesity and related diseases.

Abstract: The present invention relates to peptidomimetic compounds useful as protease inhibitors, particularly as serine protease inhibitors and more particularly as hepatitis C NS3 protease inhibitors; intermediates thereto; their preparation including novel steroselective processes to intermediates. The invention is also directed to pharmaceutical compositions and to methods for using the compounds for inhibiting HCV protease or treating a patient suffering from an HCV infection or physiological condition related to the infection. Also provided are pharmaceutical combinations comprising, in addition to one or more HCV serine protease inhibitors, one or more interferons exhibiting anti-HCV activity and/or one or more compounds having anti HCV activity and a pharmaceutically acceptable carrier, and methods for treating or preventing a HCV infection in a patient using the compositions. The present invention is also directed to a kit or pharmaceutical pack for treating or preventing HCV infection in a patient.

Abstract: A thermal insulation sheet is maneuvered into position, especially in closely confined corners in an attic, by a tool having a prong which is inserted into the sheet, and a pusher surface which contacts the sheet to limit the depth of insertion of the prong, and which guides the sheet while an installer pushes the pusher surface against the sheet while maintaining the prong in the sheet.

Abstract: There is provided an improvement to a device for slidably mounting a tube against an orifice of a medical patient, the device including a polygonal section of sponge foam, a bore through this foam and a slot for enabling the polygonal section of foam to be slid over and onto a tube. The improvement comprises a rigid backing plate that fixedly attaches to the sponge foam in an area apart from, and preferably opposite, the surface of the sponge foam section in contact with the patient's orifice. This backing plate has a bore and slot corresponding to those in the sponge foam section. With this improvement, such mounting devices may be placed in more permanent traction against the patient's nose, mouth or other orifice. A further improvement includes a gauge for varying the amount of substantially permanent traction placed on a medical tube with this device. There is also disclosed a method for supplying variable amounts of substantially permanent traction to a medical tube with the holder of this invention.