Abstract: Thin layer chromatography (TEC) devices for the analysis of pico-scale samples, methods for using the devices, and methods for fabricating the devices.

Abstract: Disclosed are monoclonal antibodies, antigen binding fragments, and bi-specific antibodies that specifically bind a coronavirus spike protein, such as SARS-CoV-2. Also disclosed is the use of these antibodies for inhibiting a coronavirus infection, such as a SARS-CoV-2 infection. In addition, disclosed are methods for detecting a coronavirus, such as SARS-CoV-2, in a biological sample, using the disclosed antibodies.

Abstract: Disclosed are antigen binding polypeptides and antigen binding polypeptide complexes (e.g., antibodies and antigen binding fragments thereof) having certain structural and/or functional features. Also disclosed are polynucleotides and vectors encoding such polypeptides and polypeptide complexes; host cells, pharmaceutical compositions and kits containing such polypeptides and polypeptide complexes; and methods of using such polypeptides and polypeptide complexes.

Abstract: This disclosure describes a novel, ready-to-use protease composition in the form of a film or pouch composition. The protease composition can be used for stabilizing a biological sample containing a nucleic acid molecule for storage or transportation. It allows quick removal of protein contamination in the biological sample, thus facilitating sample preparation for nucleic acid detection or extraction.

Abstract: The present invention features interferon-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration of treatment, such as no more than 12 weeks. In one aspect, the treatment comprises administering at least two direct acting antiviral agents to a subject with HCV infection, wherein the treatment lasts for 12 weeks and does not include administration of either interferon or ribavirin, and said at least two direct acting antiviral agents comprise (a) Compound 1 or a pharmaceutically acceptable salt thereof and (b) Compound 2 or a pharmaceutically acceptable salt thereof.

Abstract: An apparatus for collecting or culturing cells or cell colonies includes: a common substrate formed from a flexible resilient polymeric material and having a plurality of wells formed therein; and a plurality of rigid cell carriers releasably connected to said common substrate, with said carriers arranged in the form of an array, and with each of the carriers resiliently received in one of the wells. A method of collecting or culturing cells or cell colonies with such an apparatus is carried out by depositing a liquid media carrying cells on the apparatus so that said cells settle on or adhere to said the carriers; and then (c) releasing at least one selected carrier having said cells thereon by gradual application of release energy to each carrier from the cavity in which it is received (e.g., by pushing with a probe).

Abstract: An array of magnetic or paramagnetic micro-elements comprised of polysilsesquioxane is described having ultra-low-autofluorescence and other optical properties to improve microscopic imaging of cells or other objects present on the array. These materials are also amenable to chemical modification allowing surface attachment of affinity capture moieties or chemical reporters for selective binding or analysis of cells, macromolecules or other targets.

Abstract: A microelectronic device comprises a stack structure comprising a vertically alternating sequence of conductive material and insulative material arranged in tiers. The stack structure has blocks separated from one another by first dielectric slot structures. Each of the blocks comprises two crest regions, a stadium structure interposed between the two crest regions in a first horizontal direction and comprising opposing staircase structures each having steps comprising edges of the tiers of the stack structure, and two bridge regions neighboring opposing sides of the stadium structure in a second horizontal direction orthogonal to the first horizontal direction and having upper surfaces substantially coplanar with upper surfaces of the two crest regions. At least one second dielectric slot structure is within horizontal boundaries of the stadium structure in the first horizontal direction and partially vertically extends through and segmenting each of the two bridge regions.

Abstract: Multi-stage production pipeline system that may be utilized in conjunction with a motion picture project management system. The multi-stage production pipeline system includes a computer and a database. The database includes metadata associated with at least one shot or associated with regions within the plurality of images in the at least one shot, or both. The computer includes a grouping tool interface for presenting user interface elements and accepting input of the metadata associated with the at least one shot or regions within the plurality of images in the at least one shot, or both. The system enables a large studio workforce to work non-linearly on a film while maintaining a unified vision driven by key creative figures, allowing for more consistent, higher quality, faster, less expensive work product and more efficient project management techniques. The system also enables reuse of project files, masks and other production elements across projects.

Abstract: Multi-stage production pipeline system that may be utilized in conjunction with a motion picture project management system. The multi-stage production pipeline system includes a computer and a database. The database includes metadata associated with at least one shot or associated with regions within the plurality of images in the at least one shot, or both. The computer includes a grouping tool interface for presenting user interface elements and accepting input of the metadata associated with the at least one shot or regions within the plurality of images in the at least one shot, or both. The system enables a large studio workforce to work non-linearly on a film while maintaining a unified vision driven by key creative figures, allowing for more consistent, higher quality, faster, less expensive work product and more efficient project management techniques. The system also enables reuse of project files, masks and other production elements across projects.

Abstract: Multi-stage production pipeline system that may be utilized in conjunction with a motion picture project management system. The multi-stage production pipeline system includes a computer and a database. The database includes metadata associated with at least one shot or associated with regions within the plurality of images in the at least one shot, or both. The computer includes a grouping tool interface for presenting user interface elements and accepting input of the metadata associated with the at least one shot or regions within the plurality of images in the at least one shot, or both. The system enables a large studio workforce to work non-linearly on a film while maintaining a unified vision driven by key creative figures, allowing for more consistent, higher quality, faster, less expensive work product and more efficient project management techniques. The system also enables reuse of project files, masks and other production elements across projects.

Abstract: Multi-stage production pipeline system that may be utilized in conjunction with a motion picture project management system. The multi-stage production pipeline system includes a computer and a database. The database includes metadata associated with at least one shot or associated with regions within the plurality of images in the at least one shot, or both. The computer includes a grouping tool interface for presenting user interface elements and accepting input of the metadata associated with the at least one shot or regions within the plurality of images in the at least one shot, or both. The system enables a large studio workforce to work non-linearly on a film while maintaining a unified vision driven by key creative figures, allowing for more consistent, higher quality, faster, less expensive work product and more efficient project management techniques. The system also enables reuse of project files, masks and other production elements across projects.

Abstract: Multi-stage production pipeline system that may be utilized in conjunction with a motion picture project management system. The multi-stage production pipeline system includes a computer and a database. The database includes metadata associated with at least one shot or associated with regions within the plurality of images in the at least one shot, or both. The computer includes a grouping tool interface for presenting user interface elements and accepting input of the metadata associated with the at least one shot or regions within the plurality of images in the at least one shot, or both. The system enables a large studio workforce to work non-linearly on a film while maintaining a unified vision driven by key creative figures, allowing for more consistent, higher quality, faster, less expensive work product and more efficient project management techniques. The system also enables reuse of project files, masks and other production elements across projects.

Abstract: Multi-stage production pipeline system that may be utilized in conjunction with a motion picture project management system. The multi-stage production pipeline system includes a computer and a database. The database includes metadata associated with at least one shot or associated with regions within the plurality of images in the at least one shot, or both. The computer includes a grouping tool interface for presenting user interface elements and accepting input of the metadata associated with the at least one shot or regions within the plurality of images in the at least one shot, or both. The system enables a large studio workforce to work non-linearly on a film while maintaining a unified vision driven by key creative figures, allowing for more consistent, higher quality, faster, less expensive work product and more efficient project management techniques. The system also enables reuse of project files, masks and other production elements across projects.

Abstract: Multi-stage production pipeline system that may be utilized in conjunction with a motion picture project management system. The multi-stage production pipeline system includes a computer and a database. The database includes metadata associated with at least one shot or associated with regions within the plurality of images in the at least one shot, or both. The computer includes a grouping tool interface for presenting user interface elements and accepting input of the metadata associated with the at least one shot or regions within the plurality of images in the at least one shot, or both. The system enables a large studio workforce to work non-linearly on a film while maintaining a unified vision driven by key creative figures, allowing for more consistent, higher quality, faster, less expensive work product and more efficient project management techniques. The system also enables reuse of project files, masks and other production elements across projects.

Abstract: Multi-stage production pipeline system that may be utilized in conjunction with a motion picture project management system. The multi-stage production pipeline system includes a computer and a database. The database includes metadata associated with at least one shot or associated with regions within the plurality of images in the at least one shot, or both. The computer includes a grouping tool interface for presenting user interface elements and accepting input of the metadata associated with the at least one shot or regions within the plurality of images in the at least one shot, or both. The system enables a large studio workforce to work non-linearly on a film while maintaining a unified vision driven by key creative figures, allowing for more consistent, higher quality, faster, less expensive work product and more efficient project management techniques. The system also enables reuse of project files, masks and other production elements across projects.

Abstract: Print performance is evaluated by printing a diagnostic image comprising color patches. Colorant usage in the printed image is measured by, for instance, scanning each patch. Measured color values are then compared to target color values. Based on the comparison, groups of patches whose color values vary significantly from expectations are identified. Variant groups are then analyzed to identify, in addition to color quality control problems, spatial problems that affect only a localized area of a printed page. Such spatial problems may include, for example, problems with contrast or streaks. A heat map illustrating the differences may be generated to help an operator visualize the spatial problem. A template for the diagnostic image may be selected from a plurality of randomly generated diagnostic targets based on total colorant usage for at least one colorant in each column of color patches. Certain patches may be predefined across for each candidate target.

Abstract: Print performance is evaluated by printing a diagnostic image comprising color patches. Colorant usage in the printed image is measured by, for instance, scanning each patch. Measured color values are then compared to target color values. Based on the comparison, groups of patches whose color values vary significantly from expectations are identified. Variant groups are then analyzed to identify, in addition to color quality control problems, spatial problems that affect only a localized area of a printed page. Such spatial problems may include, for example, problems with contrast or streaks. A heat map illustrating the differences may be generated to help an operator visualize the spatial problem. A template for the diagnostic image may be selected from a plurality of randomly generated diagnostic targets based on total colorant usage for at least one colorant in each column of color patches. Certain patches may be predefined across for each candidate target.

Abstract: A new structure for an efficient electric pump is described. The electric pump of this invention mainly comprises a cover plate, a top cover and a housing to make up the outside appearance. Its inside consists of a dual piston device, an eccentric transmission device for the pistons to stroke up and down, an electric motor, a switch, an adjustable pressure switch, a rotary dial for adjusting said pressure switch and the associated circuitry. The cover plate has two circular ball-shaped chambers for the pistons to create the sucking and the discharging. In between the two ball-shaped chamber are discharge and suction channels which are independent from each other but are joined together. Two ends of the channel are provided with clack valves for controlling the air flow to be drawing in on one side and discharge on the other side. The pressure switch is disposed beneath the discharge channel so that the pressure switch trips when the discharge pressure extends a preset limit.