Abstract: Provided herein are methods for reducing or preventing surgery-associated hemolysis in subjects who have cold agglutinin disease (CAD) (e.g., been diagnosed with CAD or have had at least one symptom of CAD).

Abstract: Provided herein are methods of treating cold agglutinin disease (CAD) or chronic inflammatory demyelinating polyneuropathy (CIDP) in a subject in need thereof. The methods comprise administering to a subject a humanized antibody that specifically binds complement component C1s (anti-C1s antibody). Methods of treating CAD comprise administering the anti-C1s antibody to a subject in a fixed dose. Methods of treating CIDP comprise administering to a subject a weight-based loading dose of the anti-C1s antibody followed by one or more fixed maintenance doses. The methods comprise administering an effective dose of anti-C1s antibody to achieve a minimum level of CP inhibition for therapeutic effect.

Abstract: The present disclosure provides a method of treating hemophilia A in a human subject in need thereof comprising administering to the subject a chimeric polypeptide comprising (i) a factor VIII (FVIII) protein and (ii) a von Willebrand factor (VWF) fragment comprising a D? domain of VWF and a D3 domain of VWF at a dosing interval.

Abstract: A multilayer structure having a plurality of layers, with each layer being optically transparent over a selective wavelength range and being electrically conducting. The multilayer structure includes a top oxide layer having an exposed top surface that provides an outer surface of the multilayer structure and an inner surface that is opposite to the exposed top surface; a bottom oxide layer having an exposed bottom surface that provides an outer surface of the multilayer structure, which is opposite to the exposed top surface, and an inner surface that is opposite to the exposed bottom surface; a first control layer provided on the inner surface of the top oxide layer; and a second control layer provided on the inner surface of the bottom oxide layer, the first and the second control layers calibrated to have the multilayer structure attenuate light over two different wavelength ranges.

Abstract: A method of securing ties to a medical gown including providing a medical gown and associated ties made from a material that is compatible with ultrasonic welding, folding the ties prior to welding to provide more than one layer of tie material and welding the ties by ultrasonic welding through the more than one layer of tie material.

Abstract: The invention relates to the use of hydantoin compounds useful for treating or preventing autoimmune disorders. The present invention also provides compositions and uses thereof.

Abstract: The invention relates to the use of hydantoin compounds useful for treating or preventing autoimmune disorders. The present invention also provides compositions and uses thereof.

Abstract: An air filtering soft face mask has a soft body formed of multiple layers of material, including at least one layer of air filtering material capable of filtering selected contaminants from air. The body has an arcuate or peaked nose engaging edge adapted to engage a nose of a wearer and terminating in remote ends that extend downwardly. The body has a chin underlying edge adapted to underlie a chin of a wearer and terminating in remote ends that extend upwardly. The remote ends of the chin underlying edge being secured to the remote ends of the nose engaging edge to form side edges. Jaw movement tensions the body, forcing the nose engaging edge into firmer engagement with the nose of the wearer, forcing the chin underlying edge into firmer engagement with the chin of the wearer and tensioning the side edges into firmer engagement with the cheeks of the wearer.

Abstract: A face mask includes a body adapted to fit contours of a human face. The body has opposed sides. A tie strap receiving channel is positioned along each of the opposed sides of the body. A single tie strap extends through both of the tie strap receiving channels. The tie strap is freely movable along each tie strap receiving channel.

Abstract: The invention relates to the use of hydantoin compounds useful for treating or preventing autoimmune disorders. The present invention also provides compositions and uses thereof.

Abstract: The invention provides hydroxylated indole derivatives and methods of using these derivatives to treat serotonergic diseases or conditions.

Abstract: A plastic food container has a lid and a base, each of which has a flange and an inverted U-shaped rim. The flanges and rims mate to form four seals with the rim forming a large horizontal seal and two air pockets between seals to allow for easy opening.