Patents by Inventor Nanette Forsyth
Nanette Forsyth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 10357511Abstract: Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosis-inducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity. In one embodiment, a method for producing an osteoinductive composition comprises providing partially demineralized bone, treating the partially demineralized bone to disrupt the collagen structure of the bone. In another embodiment, an implantable osteoinductive and osteoconductive composition comprises partially demineralized bone, wherein the collagen structure of the bone has been disrupted, and, optionally, a tissue-derived extract.Type: GrantFiled: June 30, 2017Date of Patent: July 23, 2019Assignee: Warsaw Orthopedic, Inc.Inventors: Keyvan Behnam, Guobao Wei, Nanette Forsyth
-
Patent number: 10220115Abstract: Bone matrix compositions having nanoscale textured surfaces and methods for their production are provided. In some embodiments, bone matrix is prepared for implantation and retains nanoscale textured surfaces. In other embodiments, nanostructures are imparted to bone matrix wherein collagen fibrils on the surface of the bone matrix have been compromised, thus imparting a nanoscale textured surface to the bone matrix. Generally, these methods may be applied to mineralized or demineralized bone including partially or surface demineralized bone.Type: GrantFiled: January 27, 2017Date of Patent: March 5, 2019Assignee: Warsaw Orthopedic, Inc.Inventors: Guobao Wei, Keyvan Behnam, Nanette Forsyth
-
Patent number: 10028837Abstract: A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.Type: GrantFiled: May 6, 2016Date of Patent: July 24, 2018Assignee: Warsaw Orthopedic, Inc.Inventors: Guobao Wei, Keyvan Behnam, Nanette Forsyth, John Winterbottom, James Beisser, Todd Boyce, Mohamed Attawia, Cristy J. Richards, Lawrence A. Shimp
-
Publication number: 20170296581Abstract: Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosis-inducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity. In one embodiment, a method for producing an osteoinductive composition comprises providing partially demineralized bone, treating the partially demineralized bone to disrupt the collagen structure of the bone. In another embodiment, an implantable osteoinductive and osteoconductive composition comprises partially demineralized bone, wherein the collagen structure of the bone has been disrupted, and, optionally, a tissue-derived extract.Type: ApplicationFiled: June 30, 2017Publication date: October 19, 2017Inventors: Keyvan Behnam, Guobao Wei, Nanette Forsyth
-
Patent number: 9717822Abstract: Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosis-inducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity. In one embodiment, a method for producing an osteoinductive composition comprises providing partially demineralized bone, treating the partially demineralized bone to disrupt the collagen structure of the bone. In another embodiment, an implantable osteoinductive and osteoconductive composition comprises partially demineralized bone, wherein the collagen structure of the bone has been disrupted, and, optionally, a tissue-derived extract.Type: GrantFiled: October 16, 2015Date of Patent: August 1, 2017Assignee: Warsaw Orthopedic, Inc.Inventors: Keyvan Behnam, Guobao Wei, Nanette Forsyth
-
Publication number: 20170136149Abstract: Bone matrix compositions having nanoscale textured surfaces and methods for their production are provided. In some embodiments, bone matrix is prepared for implantation and retains nanoscale textured surfaces. In other embodiments, nanostructures are imparted to bone matrix wherein collagen fibrils on the surface of the bone matrix have been compromised, thus imparting a nanoscale textured surface to the bone matrix. Generally, these methods may be applied to mineralized or demineralized bone including partially or surface demineralized bone.Type: ApplicationFiled: January 27, 2017Publication date: May 18, 2017Inventors: Guobao Wei, Keyvan Behnam, Nanette Forsyth
-
Patent number: 9554920Abstract: Bone matrix compositions having nanoscale textured surfaces and methods for their production are provided. In some embodiments, bone matrix is prepared for implantation and retains nanoscale textured surfaces. In other embodiments, nanostructures are imparted to bone matrix wherein collagen fibrils on the surface of the bone matrix have been compromised, thus imparting a nanoscale textured surface to the bone matrix. Generally, these methods may be applied to mineralized or demineralized bone including partially or surface demineralized bone.Type: GrantFiled: November 10, 2008Date of Patent: January 31, 2017Assignee: Warsaw Orthopedic, Inc.Inventors: Guobao Wei, Keyvan Behnam, Nanette Forsyth
-
Patent number: 9492278Abstract: A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.Type: GrantFiled: July 10, 2008Date of Patent: November 15, 2016Assignee: Warsaw Orthopedic, Inc.Inventors: Guobao Wei, Nanette Forsyth, John Winterbottom, James Beisser, Todd M. Boyce, Sigurd H. Berven, Randal R. Betz, Michael F. O'Brien, Alexis P. Shelokov
-
Publication number: 20160250038Abstract: A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.Type: ApplicationFiled: May 6, 2016Publication date: September 1, 2016Inventors: Guobao Wei, Keyvan Behnam, Nanette Forsyth, John Winterbottom, James Beisser, Todd Boyce, Mohamed Attawia, Cristy J. Richards, Lawrence A. Shimp
-
Patent number: 9415136Abstract: An osteoinductive demineralized bone matrix, corresponding osteoimplants, and methods for making the osteoinductive demineralized bone matrix are disclosed. The osteoinductive demineralized bone matrix may be prepared by providing demineralized bone and altering the collagenous structure of the bone. The osteoinductive demineralized bone matrix may also be prepared by providing demineralized bone and compacting the bone, for example via mechanical compaction, grinding into a particulate, or treatment with a chemical. Additives such as growth factors or bioactive agents may be added to the osteoinductive demineralized bone matrix. The osteoinductive demineralized bone matrix may form an osteogenic osteoimplant. The osteoimplant, when implanted in a mammalian body, may induce at the locus of the implant the full developmental cascade of endochondral bone formation including vascularization, mineralization, and bone marrow differentiation.Type: GrantFiled: May 23, 2014Date of Patent: August 16, 2016Assignee: Warsaw Orthopedic, Inc.Inventors: Keyvan Behnam, Nanette Forsyth, James Russell, John Winterbottom, Todd Boyce
-
Patent number: 9393116Abstract: A method of repairing and/or treating bone is provided. The method includes implanting at a repair site an osteoimplant having a coherent aggregate of entangled elongate bone particles mixed with a biocompatible fluid carrier, the osteoimplant being flexible and further being formed as a strip at least one end of which possesses a tab for facilitating combination with another implant.Type: GrantFiled: September 14, 2012Date of Patent: July 19, 2016Assignee: Warsaw Orthopedic, Inc.Inventors: Randal R. Betz, Scott D. Boden, Christine Clark, Nanette Forsyth, John W. Morris, Kathy Traianedes
-
Patent number: 9358113Abstract: A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.Type: GrantFiled: July 10, 2008Date of Patent: June 7, 2016Assignee: Warsaw Orthopedic, Inc.Inventors: Guobao Wei, Keyvan Behnam, Nanette Forsyth, John Winterbottom, James Beisser, Todd M. Boyce
-
Publication number: 20160144075Abstract: Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosis-inducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity. In one embodiment, a method for producing an osteoinductive composition comprises providing partially demineralized bone, treating the partially demineralized bone to disrupt the collagen structure of the bone. In another embodiment, an implantable osteoinductive and osteoconductive composition comprises partially demineralized bone, wherein the collagen structure of the bone has been disrupted, and, optionally, a tissue-derived extract.Type: ApplicationFiled: October 16, 2015Publication date: May 26, 2016Inventors: Keyvan Behnam, Guobao Wei, Nanette Forsyth
-
Patent number: 9333082Abstract: A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.Type: GrantFiled: September 5, 2008Date of Patent: May 10, 2016Assignee: Warsaw Orthopedic, Inc.Inventors: Guobao Wei, Keyvan Behnam, Nanette Forsyth, John Winterbottom, James Beisser, Todd M. Boyce, Mohamed Attawia, Cristy J. Richards, Lawrence A. Shimp
-
Patent number: 9162012Abstract: Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosis-inducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity. In one embodiment, a method for producing an osteoinductive composition comprises providing partially demineralized bone, treating the partially demineralized bone to disrupt the collagen structure of the bone. In another embodiment, an implantable osteoinductive and osteoconductive composition comprises partially demineralized bone, wherein the collagen structure of the bone has been disrupted, and, optionally, a tissue-derived extract.Type: GrantFiled: June 20, 2014Date of Patent: October 20, 2015Assignee: Warsaw Orthopedic, Inc.Inventors: Kevyan Benham, Guobao Wei, Nanette Forsyth
-
Publication number: 20150258245Abstract: Methods for delipidation, viral inactivation and terminal sterilization are provided for bone grafting material. The methods include contacting bone material with an amount of supercritical fluid effective to remove at least lipids and at least contaminants from the bone material, thereby obtaining a terminally sterilized and delipidated bone material. In various embodiments, the substantially terminally sterilized and delipidated bone material is 99.0%, 99.5% or 99.9% free of lipids and contaminants. Contaminants that are removed from bone material by terminal sterilization with supercritical fluid include infectious organisms, such as bacteria, viruses, protozoa, parasites, fungi and mold. Bone material or bone compositions that can be treated with critical or supercritical fluids comprise mineralized or demineralized bone particles, mineralized or demineralized bone matrix, partially demineralized bone matrix or combinations thereof.Type: ApplicationFiled: March 13, 2014Publication date: September 17, 2015Applicant: Warsaw Orthopedic. Inc.Inventors: Keyvan Behnam, Guobao Wei, Nanette Forsyth, James A. Beisser
-
Publication number: 20140302112Abstract: Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosis-inducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity. In one embodiment, a method for producing an osteoinductive composition comprises providing partially demineralized bone, treating the partially demineralized bone to disrupt the collagen structure of the bone. In another embodiment, an implantable osteoinductive and osteoconductive composition comprises partially demineralized bone, wherein the collagen structure of the bone has been disrupted, and, optionally, a tissue-derived extract.Type: ApplicationFiled: June 20, 2014Publication date: October 9, 2014Inventors: Kevyan Benham, Guobao Wei, Nanette Forsyth
-
Publication number: 20140255506Abstract: An osteoinductive demineralized bone matrix, corresponding osteoimplants, and methods for making the osteoinductive demineralized bone matrix are disclosed. The osteoinductive demineralized bone matrix may be prepared by providing demineralized bone and altering the collagenous structure of the bone. The osteoinductive demineralized bone matrix may also be prepared by providing demineralized bone and compacting the bone, for example via mechanical compaction, grinding into a particulate, or treatment with a chemical. Additives such as growth factors or bioactive agents may be added to the osteoinductive demineralized bone matrix. The osteoinductive demineralized bone matrix may form an osteogenic osteoimplant. The osteoimplant, when implanted in a mammalian body, may induce at the locus of the implant the full developmental cascade of endochondral bone formation including vascularization, mineralization, and bone marrow differentiation.Type: ApplicationFiled: May 23, 2014Publication date: September 11, 2014Applicant: WARSAW ORTHOPEDIC, INC.Inventors: Keyvan Behnam, Nanette Forsyth, James Russell, John Winterbottom, Todd Boyce
-
Patent number: 8758792Abstract: Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosis-inducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity. In one embodiment, a method for producing an osteoinductive composition comprises providing partially demineralized bone, treating the partially demineralized bone to disrupt the collagen structure of the bone, and optionally providing a tissue-derived extract and adding the tissue-derived extract to the partially demineralized bone.Type: GrantFiled: January 22, 2013Date of Patent: June 24, 2014Assignee: Warsaw Orthopedic, Inc.Inventors: Keyvan Behnam, Guobao Wei, Nanette Forsyth
-
Patent number: 8734525Abstract: An osteoinductive demineralized bone matrix, corresponding osteoimplants, and methods for making the osteoinductive demineralized bone matrix are disclosed. The osteoinductive demineralized bone matrix may be prepared by providing demineralized bone and altering the collagenous structure of the bone. The osteoinductive demineralized bone matrix may also be prepared by providing demineralized bone and compacting the bone, for example via mechanical compaction, grinding into a particulate, or treatment with a chemical. Additives such as growth factors or bioactive agents may be added to the osteoinductive demineralized bone matrix. The osteoinductive demineralized bone matrix may form an osteogenic osteoimplant. The osteoimplant, when implanted in a mammalian body, may induce at the locus of the implant the full developmental cascade of endochondral bone formation including vascularization, mineralization, and bone marrow differentiation.Type: GrantFiled: June 16, 2008Date of Patent: May 27, 2014Assignee: Warsaw Orthopedic, Inc.Inventors: Keyvan Behnam, Nanette Forsyth, James Russell, John Winterbottom, Todd Boyce