Patents by Inventor Nanhai HE

Nanhai HE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • System and method for screening and assessing agents for tumor immunotherapy
    Patent number: 11965875
    Abstract: The present application relates to a system and a method for effectively screening and assessing agents for tumor immunotherapy, which includes assessment for the effects of target cells, non-target cells, and tumor infiltration. The system and method of the present application can be used to comprehensively and systematically assess the effectiveness and safety of the agent against tumor immune cells.
    Type: Grant
    Filed: May 18, 2021
    Date of Patent: April 23, 2024
    Assignee: ADLAI NORTYE BIOPHARMA CO. LTD.
    Inventors: Nanhai He, Youping Wang, Yang Lu, Donghui Yang
  • BIOMARKER AND APPLICATION THEREOF
    Publication number: 20240085425
    Abstract: The present disclosure provides an application of non-phosphorylated ?-catenin protein in tumor cells as a biomarker for predicting the responsivity or sensitivity of tumor cells to wnt pathway inhibitors, a method of using non-phosphorylated ?-catenin protein in tumor cells as a biomarker to predict the responsivity or sensitivity of tumor cells to wnt pathway inhibitors, a method for treating tumor patients, a method for detecting the content of non-phosphorylated ?-catenin in tumor tissues or tumor cells, and a suitable wnt inhibitor.
    Type: Application
    Filed: August 18, 2023
    Publication date: March 14, 2024
    Applicant: ADLAI NORTYE BIOPHARMA CO., LTD.
    Inventors: Nanhai HE, Youping WANG, Zhihong LIU, Yufeng CHEN
  • HIGH ACTIVITY HPK1 KINASE INHIBITOR
    Publication number: 20230399327
    Abstract: A compound of formula (I) having the activity of inhibiting HPK1 kinase and a pharmaceutical composition comprising the compound. Also provided are the use of the compound in the prevention and/or treatment of cancers, tumors, inflammatory diseases, autoimmune diseases or immune-mediated diseases.
    Type: Application
    Filed: October 26, 2021
    Publication date: December 14, 2023
    Applicant: ADLAI NORTYE BIOPHARMA CO., LTD.
    Inventors: Yufeng CHEN, Canfeng LIU, Meng LV, Qiaodong WEN, Yongqiang SHI, Peng WU, Kaixuan CHEN, Han YANG, Wanli CHENG, Youping WANG, Pingping LU, Nanhai HE
  • HIGH-ACTIVITY WNT PATHWAY INHIBITOR COMPOUND
    Publication number: 20230390301
    Abstract: Provided are a compound having the structure of formula (I) for inhibiting Wnt pathway activity, a pharmaceutical composition comprising the compound, and use of the compound in prevention and/or treatment of cancers, tumors, inflammatory diseases, autoimmune diseases, or immune-mediated diseases.
    Type: Application
    Filed: October 27, 2021
    Publication date: December 7, 2023
    Applicant: ADLAI NORTYE BIOPHARMA CO., LTD.
    Inventors: Yufeng CHEN, Peng WU, Meng LV, Canfeng LIU, Han YANG, Kaixuan CHEN, Wanli CHENG, Feifan LI, Youping WANG, Keke CHEN, Pingping LU, Nanhai HE
  • Construction of fully human antibody yeast display technique
    Patent number: 11680271
    Abstract: The present disclosure application relates to a construction method of a yeast display library (YSD), specifically to a construct for a yeast display library, an expression vector, a host cell and a construction method and use thereof. The yeast display library provided by the present application has high transformation efficiency and rich diversity.
    Type: Grant
    Filed: May 17, 2021
    Date of Patent: June 20, 2023
    Assignee: ADLAI NORTYE BIOPHARMA CO., LTD.
    Inventors: Nanhai He, Dandan Chen, Yang Lu, Donghui Yang
  • SYSTEM AND METHOD FOR SCREENING AND ASSESSING AGENTS FOR TUMOR IMMUNOTHERAPY
    Publication number: 20220155282
    Abstract: The present application relates to a system and a method for effectively screening and assessing agents for tumor immunotherapy, which includes assessment for the effects of target cells, non-target cells, and tumor infiltration. The system and method of the present application can be used to comprehensively and systematically assess the effectiveness and safety of the agent against tumor immune cells.
    Type: Application
    Filed: May 18, 2021
    Publication date: May 19, 2022
    Inventors: Nanhai HE, Youping WANG, Yang LU, Donghui YANG
  • CONSTRUCTION OF FULLY HUMAN ANTIBODY YEAST DISPLAY TECHNIQUE
    Publication number: 20220135988
    Abstract: The present disclosure application relates to a construction method of a yeast display library (YSD), specifically to a construct for a yeast display library, an expression vector, a host cell and a construction method and use thereof. The yeast display library provided by the present application has high transformation efficiency and rich diversity.
    Type: Application
    Filed: May 17, 2021
    Publication date: May 5, 2022
    Inventors: Nanhai HE, Dandan CHEN, Yang LU, Donghui YANG