Patents by Inventor Naoki Iwamoto
Naoki Iwamoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190209604Abstract: The present disclosure pertains to the recognition that immune responses mediated by CpG oligonucleotides can be affected by the stereochemistry of modified internucleotidic linkages such as phosphorothioates. In some embodiments, the present disclosure relates to chirally controlled CpG oligonucleotide compositions comprising CpG oligonucleotides comprising multiple modified internucleotidic linkages such as phosphorothioate linkages, wherein the oligonucleotides comprise one or more CpG region motifs having defined stereochemistry patterns of chiral internucleotidic linkages. In some embodiments, CpG oligonucleotides comprising one or more CpG region motifs are capable of agonizing an immune response. In some embodiments, CpG oligonucleotides comprising one or more CpG region motifs are antagonistic. Methods for making and using chirally controlled CpG oligonucleotide compositions are also described.Type: ApplicationFiled: June 2, 2017Publication date: July 11, 2019Applicant: WAVE LIFE SCIENCES LTD.Inventors: Jason Jingxin Zhang, Naoki Iwamoto, Christopher J. Francis, Chandra Vargeese, David Charles Donnell Butler, Sethumadhavan Divakaramenon, Genliang Lu, Subramanian Marappan
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Patent number: 10307434Abstract: Described herein are nucleic acid prodrugs and nucleic acid prodrugs comprising chiral phosphorous moieties. Also described herein are methods of making and using nucleic acid prodrugs and nucleic acid prodrugs comprising chiral phosphorous moieties.Type: GrantFiled: May 27, 2016Date of Patent: June 4, 2019Assignee: WAVE LIFE SCIENCES LTD.Inventors: Gregory L. Verdine, Meena, Naoki Iwamoto
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Patent number: 10280192Abstract: The present application, among other things, provides technologies, e.g., reagents, methods, etc. for preparing oligonucleotides comprising phosphorothiotriesters linkages. In some embodiments, provided methods comprise reacting an H-phosphonate of structure Ia or Ib with a silylating reagent to provide a silyloxyphosphonate, and reacting the silyloxyphosphonate with a thiosulfonate reagent of structure IIa or IIb to provide an oligonucleotide of structure IIIa or IIIb. In some embodiments, provided methods comprise reacting an H-phosphonate of structure Ic with a silylating reagent to provide a silyloxyphosphonate, reacting the silyloxyphosphonate with a bis(thiosulfonate) reagent of structure IVc to provide a phosphorothiotriester comprising a thiosulfonate group of structure Vc, and then reacting the phosphorothiotriester comprising a thiosulfonate group of structure Vc with a nucleophile of structure VIc to provide an oligonucleotide of structure IIIc.Type: GrantFiled: March 30, 2018Date of Patent: May 7, 2019Assignee: WAVE LIFE SCIENCES LTD.Inventors: Gregory L. Verdine, Meena, Naoki Iwamoto, David Charles Donnell Butler
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Publication number: 20190127733Abstract: Among other things, the present disclosure relates to designed oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide altered splicing of a transcript. In some embodiments, provided oligonucleotide compositions have low toxicity. In some embodiments, provided oligonucleotide compositions provide improved protein binding profiles. In some embodiments, provided oligonucleotide compositions have improved delivery. In some embodiments, provided oligonucleotide compositions have improved uptake. In some embodiments, the present disclosure provides methods for treatment of diseases using provided oligonucleotide compositions.Type: ApplicationFiled: October 7, 2016Publication date: May 2, 2019Inventors: David Charles Donnell Butler, Sethumadhavan Divakaramenon, Christopher J. Francis, Maria David Frank-Kamenetsky, Naoki Iwamoto, Genliang Lu, Subramanian Marappan, Meena ., Chandra Vargeese, Gregory L. Verdine, Hailin Yang, Jason Jingxin Zhang
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Publication number: 20190106696Abstract: The present invention relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same. In some embodiments, a provided chirally controlled oligonucleotide composition provides different cleavage patterns of a nucleic acid polymer than a reference oligonucleotide composition. In some embodiments, a provided chirally controlled oligonucleotide composition provides single site cleavage within a complementary sequence of a nucleic acid polymer.Type: ApplicationFiled: August 22, 2018Publication date: April 11, 2019Inventors: Meena, David Butler, Naoki Iwamoto, Nenad Svrzikapa, Gregory L. Verdine, Ivan Zlatev
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Publication number: 20190008986Abstract: Among other things, the present disclosure relates to designed oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide altered splicing of a transcript. In some embodiments, provided oligonucleotide compositions have low toxicity. In some embodiments, provided oligonucleotide compositions provide improved protein binding profiles. In some embodiments, provided oligonucleotide compositions have improved delivery. In some embodiments, provided oligonucleotide compositions have improved uptake. In some embodiments, the present disclosure provides methods for treatment of diseases using provided oligonucleotide compositions.Type: ApplicationFiled: September 23, 2018Publication date: January 10, 2019Inventors: David Charles Donnell Butler, Sethumadhavan Divakaramenon, Christopher J. Francis, Maria David Frank-Kamenetsky, Naoki Iwamoto, Genliang Lu, Subramanian Marappan, Meena ., Chandra Vargeese, Gregory L. Verdine, Hailin Yang, Jason Jingxin Zhang
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Patent number: 10160969Abstract: The present invention relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same. In some embodiments, a provided chirally controlled oligonucleotide composition provides different cleavage patterns of a nucleic acid polymer than a reference oligonucleotide composition. In some embodiments, a provided chirally controlled oligonucleotide composition provides single site cleavage within a complementary sequence of a nucleic acid polymer.Type: GrantFiled: January 16, 2015Date of Patent: December 25, 2018Assignee: WAVE LIFE SCIENCES LTD.Inventors: Meena, David Butler, Naoki Iwamoto, Nenad Svrzikapa, Gregory L. Verdine, Ivan Zlatev
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Publication number: 20180268974Abstract: A superconducting magnet device with which device breakage caused by a quench can be avoided while helium consumption is reduced. A sheet-like convection-preventing member is disposed at least either above or below a heat transfer member transferring to gaseous helium heat transferred from the outside, so as to cover a helium gas release tube for the gaseous helium, and thus heat exchange performance during transportation is improved. In the case where the quench occurs, the convection-preventing member is lifted upward in the release tube, thereby ensuring to provide a flow path for the gaseous helium and avoiding excessive increase of the internal pressure.Type: ApplicationFiled: May 25, 2016Publication date: September 20, 2018Applicant: Mitsubishi Electric CorporationInventors: Naoki IWAMOTO, Hajime TAMURA, Tatsuya INOUE, Ryo EGUCHI
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Publication number: 20180222936Abstract: Described herein are methods for the synthesis of derivatives of thiosulfonate reagents. Said reagents have utility for the synthesis of phosphorothiotriesters from H-phosphonates in a stereospecific fashion.Type: ApplicationFiled: March 30, 2018Publication date: August 9, 2018Inventors: Gregory L. Verdine, Meena, Naoki Iwamoto, David Charles Donnell Butler
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Patent number: 10011154Abstract: An in-vehicle cooling device includes: a header to be mounted so as to be adjacent to a side surface of a transformer mounted on a back side of a bottom portion of a vehicle, the header having a vertical surface along a traveling direction and a direction orthogonal to the travelling direction; a vertical-direction installed cooling pipe having both ends fixed to the header and being installed on a vertical plane orthogonal to the traveling direction; and a traveling-direction installed cooling pipe having both ends fixed to the header and being installed on a travel plane that is parallel to a horizontal plane, the vertical-direction installed cooling pipe and the traveling-direction installed cooling pipe being installed to overlap with each other in a direction orthogonal to the header.Type: GrantFiled: October 1, 2013Date of Patent: July 3, 2018Assignee: Mitsubishi Electric CorporationInventors: Naoki Iwamoto, Koji Kise, Toshihiro Noda
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Patent number: 9982257Abstract: The present invention relates to chirally controlled oligonucleotides, chirally controlled oligonucleotide compositions, and the method of making and using the same. The invention specifically encompasses the identification of the source of certain problems with prior methodologies for preparing chiral oligonucleotides, including problems that prohibit preparation of fully chirally controlled compositions, particularly compositions comprising a plurality of oligonucleotide types. In some embodiments, the present invention provides chirally controlled oligonucleotide compositions. In some embodiments, the present invention provides methods of making chirally controlled oligonucleotides and chirally controlled oligonucleotide compositions.Type: GrantFiled: July 12, 2013Date of Patent: May 29, 2018Assignee: WAVE LIFE SCIENCES LTD.Inventors: David Butler, Naoki Iwamoto, Meena, Nenad Svrzikapa, Gregory L. Verdine, Ivan Zlatev
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Patent number: 9982898Abstract: An indoor unit includes a casing having a suction port formed in an upper part and a blow-out port formed on a lower side at a front face part, an axial-flow or diagonal-flow fan provided on the downstream side of the suction port in the casing, and a heat exchanger provided on the downstream side of the fan and on the upstream side of the blow-out port in the casing, in which air blown out of the fan and refrigerant are heat-exchanged.Type: GrantFiled: October 2, 2009Date of Patent: May 29, 2018Assignee: Mitsubishi Electric CorporationInventors: Shoji Yamada, Kenichi Sakoda, Masao Akiyoshi, Akira Takamori, Nobuaki Uehara, Tomoya Fukui, Seiji Nakashima, Naoki Iwamoto, Satoshi Michihata, Isao Otsuka, Masayuki Tsuji
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Patent number: 9958813Abstract: An image forming apparatus includes a transferring belt, photosensitive drums, primary transferring parts, a transfer voltage applying part, a resistance value measuring part, a cleaning device, a pre-brush, a pre-brush current detecting part and a transfer voltage correcting part. The pre-brush applies a cleaning charge voltage to the remained toner at an upstream side from the cleaning device in the rotation direction of the transferring belt. The transfer voltage correcting part, by a subject resistance value of the primary transferring part measured by the resistance value measuring part, corrects a transfer voltage of the primary transferring part. As a measurement condition, if a change quantity of the pre-brush current from the last transfer voltage correction is equal to or more than a predetermined change threshold, the resistance value measuring part executes measurement of the subject resistance value and the transfer voltage correcting part executes correction of the transfer voltage.Type: GrantFiled: July 7, 2017Date of Patent: May 1, 2018Assignee: KYOCERA Document Solutions Inc.Inventor: Naoki Iwamoto
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Patent number: 9885037Abstract: The present invention relates to chirally controlled oligonucleotides, chirally controlled oligonucleotide compositions, and the method of making and using the same. The invention specifically encompasses the identification of the source of certain problems with prior methodologies for preparing chiral oligonucleotides, including problems that prohibit preparation of fully chirally controlled compositions, particularly compositions comprising a plurality of oligonucleotide types. In some embodiments, the present invention provides chirally controlled oligonucleotide compositions. In some embodiments, the present invention provides methods of making chirally controlled oligonucleotides and chirally controlled oligonucleotide compositions.Type: GrantFiled: July 12, 2013Date of Patent: February 6, 2018Assignee: WAVE LIFE SCIENCES LTD.Inventors: David Butler, Naoki Iwamoto, Meena, Nenad Svrzikapa, Gregory L. Verdine, Ivan Zlatev
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Publication number: 20180017905Abstract: An image forming apparatus includes a transferring belt, photosensitive drums, primary transferring parts, a transfer voltage applying part, a resistance value measuring part, a cleaning device, a pre-brush, a pre-brush current detecting part and a transfer voltage correcting part. The pre-brush applies a cleaning charge voltage to the remained toner at an upstream side from the cleaning device in the rotation direction of the transferring belt. The transfer voltage correcting part, by a subject resistance value of the primary transferring part measured by the resistance value measuring part, corrects a transfer voltage of the primary transferring part. As a measurement condition, if a change quantity of the pre-brush current from the last transfer voltage correction is equal to or more than a predetermined change threshold, the resistance value measuring part executes measurement of the subject resistance value and the transfer voltage correcting part executes correction of the transfer voltage.Type: ApplicationFiled: July 7, 2017Publication date: January 18, 2018Applicant: KYOCERA Document Solutions Inc.Inventor: Naoki IWAMOTO
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Publication number: 20170275621Abstract: The present invention relates to chirally controlled oligonucleotides, chirally controlled oligonucleotide compositions, and the method of making and using the same. The invention specifically encompasses the identification of the source of certain problems with prior methodologies for preparing chiral oligonucleotides, including problems that prohibit preparation of fully chirally controlled compositions, particularly compositions comprising a plurality of oligonucleotide types. In some embodiments, the present invention provides chirally controlled oligonucleotide compositions. In some embodiments, the present invention provides methods of making chirally controlled oligonucleotides and chirally controlled oligonucleotide compositions.Type: ApplicationFiled: March 17, 2017Publication date: September 28, 2017Inventors: David Charles Donnell Butler, Naoki Iwamoto, Meena ., Nenad Svrzikapa, Gregory L. Verdine, Ivan Zlatev
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Patent number: 9744183Abstract: Described herein are nucleic acid prodrugs and nucleic acid prodrugs comprising chiral phosphorous moieties. Also described herein are methods of making and using nucleic acid prodrugs and nucleic acid prodrugs comprising chiral phosphorous moieties.Type: GrantFiled: July 6, 2010Date of Patent: August 29, 2017Assignee: WAVE LIFE SCIENCES LTD.Inventors: Gregory L. Verdine, Meena ., Naoki Iwamoto
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Patent number: 9605019Abstract: The present application, among other things, provides technologies, e.g., reagents, methods, etc. for preparing oligonucleotides comprising phosphorothiotriesters linkages, e.g., oligonucleotides having the structure of IIIa, IIIb or IIIc. In some embodiments, provided methods comprise reacting an H-phosphonate of structure Ia or Ib with a silylating reagent to provide a silyloxyphosphonate, and reacting the silyloxyphosphonate with a thiosulfonate reagent of structure IIa or IIb to provide an oligonucleotide of structure IIIa or IIIb.Type: GrantFiled: July 13, 2012Date of Patent: March 28, 2017Assignee: WAVE LIFE SCIENCES LTD.Inventors: Gregory L. Verdine, Meena, Naoki Iwamoto, David Charles Donnell Butler
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Publication number: 20170037399Abstract: The present invention relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same. In some embodiments, a provided chirally controlled oligonucleotide composition provides different cleavage patterns of a nucleic acid polymer than a reference oligonucleotide composition. In some embodiments, a provided chirally controlled oligonucleotide composition provides single site cleavage within a complementary sequence of a nucleic acid polymer.Type: ApplicationFiled: January 16, 2015Publication date: February 9, 2017Inventors: Meena ., David Butler, Naoki Iwamoto, Nenad Svrzikapa, Gregory L. Verdine, Ivan Zlatev
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Publication number: 20170029457Abstract: Described herein are methods for the synthesis of derivatives of thiosulfonate reagents. Said reagents have utility for the synthesis of phosphorothiotriesters from H-phosphonates in a stereospecific fashion.Type: ApplicationFiled: July 28, 2016Publication date: February 2, 2017Inventors: Gregory L. Verdine, Meena, Naoki Iwamoto, David Charles Donnell Butler