Abstract: An engine system is provided, which includes an engine, a swirl control valve, and a controller. The engine includes a cylinder, a piston, and a fuel injection valve provided incliningly with respect to an axial direction of the piston and configured to directly inject fuel into the cylinder. The swirl control valve is provided inside an intake passage and generates a swirl flow inside the cylinder at least when the valve closes. When an engine load is below a given threshold, the controller controls the swirl control valve to close, and controls the fuel injection valve to inject fuel during an intake stroke. While the engine load is below the threshold, at a fixed engine speed, the controller controls to advance a fuel injection timing when the engine load is at a first load, compared with at a second load higher than the first load.

Abstract: An engine system is provided, which includes an engine, a swirl control valve, an EGR passage, an EGR gas adjusting mechanism, and a controller. The engine includes a cylinder, a piston, and a fuel injection valve. The swirl control valve is provided inside an intake passage and generates a swirl flow inside the cylinder when it closes. When an engine load is at or below a given threshold, the controller controls the swirl control valve to close. While the engine load is the threshold or below, the controller controls the EGR gas adjusting mechanism such that, at a fixed engine speed, an increase rate of an EGR gas amount with respect to an increase in the engine load is lower in a first load range than in a second load range, the first load range being on a higher load side of the second load range and including the threshold.

Abstract: An engine system is provided, which includes an engine, a swirl control valve, and a controller. The engine includes a cylinder, a piston, and a fuel injection valve provided incliningly with respect to an axial direction of the piston and configured to directly inject fuel into the cylinder. The swirl control valve is provided inside an intake passage and generates a swirl flow inside the cylinder at least when the valve closes. When an engine load is below a given threshold, the controller controls the swirl control valve to close, and controls the fuel injection valve to inject fuel during an intake stroke. While the engine load is below the threshold, at a fixed engine speed, the controller controls to advance a fuel injection timing when the engine load is at a first load, compared with at a second load higher than the first load.

Abstract: An engine system is provided, which includes an engine, a swirl control valve, an EGR passage, an EGR gas adjusting mechanism, and a controller. The engine includes a cylinder, a piston, and a fuel injection valve. The swirl control valve is provided inside an intake passage and generates a swirl flow inside the cylinder when it closes. When an engine load is at or below a given threshold, the controller controls the swirl control valve to close. While the engine load is the threshold or below, the controller controls the EGR gas adjusting mechanism such that, at a fixed engine speed, an increase rate of an EGR gas amount with respect to an increase in the engine load is lower in a first load range than in a second load range, the first load range being on a higher load side of the second load range and including the threshold.

Abstract: Disclosed herein, inter alia, are methods and uses for treating a cancer in a subject. In various embodiments, a method or use includes measuring expression of nuclear factor erythroid-2 related factor 2 (NRF2), or an NRF2 target gene, in a candidate subject having cancer, or a cancer sample from the candidate subject, and determining the amount of NRF2 in the sample or in the subject having cancer, then comparing the amount of NRF2 determined, or NRF2 target gene determined, to a baseline or reference amount of NRF2 or NRF2 target gene. If the amount of NRF2 or NRF2 target gene in the sample or in the subject having cancer is less than the baseline or reference amount of NRF2 or NRF2 target gene, the subject having the cancer may be or is treated with a peptide or peptidomimetic sequence set forth herein, such as P1, P2, P3, P4, P5, P6 (SEQ ID NO:1) or P6, P5, P4, P3, P2, P1 (SEQ ID NO:2), e.g., CBP501.

Abstract: This invention provides compounds including peptides and peptidomimetics that can be used to treat cell proliferative disorders, such as those associated with benign and malignant tumor cells. While the invention is not limited to any particular mechanism, the compounds of the invention appear to function at least in part by inhibiting G2 cell cycle checkpoint. Thus, invention compounds can be used to inhibit cell growth alone or be used in combination with a nucleic acid damaging treatment to inhibit cell growth.

Abstract: This invention provides compounds including peptides and peptidomimetics that can be used to treat cell proliferative disorders, such as those associated with benign and malignant tumor cells. While the invention is not limited to any particular mechanism, the compounds of the invention appear to function at least in part by inhibiting G2 cell cycle checkpoint. Thus, invention compounds can be used to inhibit cell growth alone or be used in combination with a nucleic acid damaging treatment to inhibit cell growth.

Abstract: A brushless motor according to the present invention provided with a recording disk in a rotational member and serving to rotate the recording disk together with the rotational member comprises a first position detecting means for detecting a rotational position of the rotational member, a second position detecting means for detecting a rotational position of the recording disk, wherein a mode for rotating the rotational member at a high speed by a detection signal of the first position detecting means and a mode for rotating the rotational member at a low speed by a detection signal of the second position detecting means are generated. Thereby, the two rotation states whose rotation speeds are different can be obtained in a simplified constitution.

Abstract: A brushless motor according to the present invention provided with a recording disk in a rotational member and serving to rotate the recording disk together with the rotational member comprises a first position detecting means for detecting a rotational position of the rotational member, a second position detecting means for detecting a rotational position of the recording disk, wherein a mode for rotating the rotational member at a high speed by a detection signal of the first position detecting means and a mode for rotating the rotational member at a low speed by a detection signal of the second position detecting means are generated. Thereby, the two rotation states whose rotation speeds are different can be obtained in a simplified constitution.