Abstract: A calculation device (10) includes a calculation unit (14) that: acquires culture data over time indicating a relationship between a DO value detected in a culture solution and an oxygen supply amount controlled by a freely-selected control method, the culture solution being stored in a first culture tank (2) in which a culturing target material is cultured; identifies a culture model indicating a relationship between the oxygen supply amount for the culturing target material increasing over time and the DO value, based on the culture data; and executes simulation of virtually culturing the culturing target material in a second culture tank (20) using a culture control method of culturing the culturing target material based on the culture model and the oxygen supply amount in the second culture tank, and calculates parameters to be used in the culture control method based on the simulation result.

Abstract: Provided is a technique for continuously performing poor solvent crystallization or reactive crystallization. A porous membrane in which multiple pores through which a liquid passes are formed internally partitions the treatment container into a first flow space and a second flow space. A raw material liquid supply unit continuously supplies a raw material liquid to the first flow space. A treatment liquid supply unit continuously supplies a treatment liquid to the second flow space at a pressure at which the treatment liquid passes through the porous membrane and enters the first flow space. An extraction unit continuously extracts a mixed liquid of the raw material liquid and the treatment liquid from the first flow space. An aging unit precipitates and grows crystals of a target substance from a mixed liquid.

Abstract: A calculation device (10) includes a calculation unit (14) that: acquires culture data over time indicating a relationship between a DO value detected in a culture solution and an oxygen supply amount controlled by a freely-selected control method, the culture solution being stored in a first culture tank (2) in which a culturing target material is cultured; identifies a culture model indicating a relationship between the oxygen supply amount for the culturing target material increasing over time and the DO value, based on the culture data; and executes simulation of virtually culturing the culturing target material in a second culture tank (20) using a culture control method of culturing the culturing target material based on the culture model and the oxygen supply amount in the second culture tank, and calculates parameters to be used in the culture control method based on the simulation result.

Abstract: A fluid mixing unit includes a cylindrical porous body partitioning a container into a first flow space and a second flow space surrounding the first flow space. A first supply port supplies a first fluid to one of the first and second flow spaces. A second supply port provided on one end side of the container in an axial direction of the cylindrical body supplies a second fluid to the other flow space. An outlet for a mixed fluid is provided on the other end side of the container to be open only to the other flow space. Closing members are provided in a plurality of stages along the axial direction to alternately close a right and a left of the other flow space as seen in the axial direction in the other flow space. A meandering flow is formed in the other flow space to create the mixed fluid.

Abstract: Provided is a technique for continuously performing poor solvent crystallization or reactive crystallization. A porous membrane in which multiple pores through which a liquid passes are formed internally partitions the treatment container into a first flow space and a second flow space. A raw material liquid supply unit continuously supplies a raw material liquid to the first flow space. A treatment liquid supply unit continuously supplies a treatment liquid to the second flow space at a pressure at which the treatment liquid passes through the porous membrane and enters the first flow space. An extraction unit continuously extracts a mixed liquid of the raw material liquid and the treatment liquid from the first flow space. An aging unit precipitates and grows crystals of a target substance from a mixed liquid.

Abstract: A silver powder, wherein the silver powder satisfies D50-IPA>D50-W, where in measurement of a volume-based particle size distribution of the silver powder by a laser diffraction particle size distribution analysis, D50-IPA (?m) is a cumulative 50% point of particle diameter of the silver powder when isopropyl alcohol (IPA) is used as a measurement solvent for dispersing the silver powder, and D50-W (?m) is a cumulative 50% point of particle diameter of the silver powder when water is used as a measurement solvent for dispersing the silver powder, and wherein a phosphorus content in the silver powder is 0.01% by mass or more but 0.3% by mass or less.

Abstract: A reciprocating stirrer device with which favorable gas absorption into the stirred substance can be obtained. The reciprocating stirrer device is obtained from: a stirring vessel in which the substance to be stirred is placed; a reciprocating drive shaft provided inside the stirring vessel; a stirring blade connected and affixed so as to intersect the drive shaft; and a microbubble-generating unit. The microbubble-generating unit is obtained from a sparger that is made of a porous body and a gas supply means for supplying a gas to the sparger. Bubbles are generated in the substance being stirred by passing gas supplied to the sparger by the gas supply means through pores of the porous body.

Abstract: A silver powder, wherein the silver powder satisfies D50-IPA>D50-W, where in measurement of a volume-based particle size distribution of the silver powder by a laser diffraction particle size distribution analysis, D50-IPA (?m) is a cumulative 50% point of particle diameter of the silver powder when isopropyl alcohol (IPA) is used as a measurement solvent for dispersing the silver powder, and D50-W (?m) is a cumulative 50% point of particle diameter of the silver powder when water is used as a measurement solvent for dispersing the silver powder, and wherein a phosphorus content in the silver powder is 0.01% by mass or more but 0.3% by mass or less.

Abstract: To provide a silver powder including alkenylsuccinic anhydride and/or alkenylsuccinic acid on a surface of the silver powder.

Abstract: A silver powder, wherein the silver powder satisfies D50-IPA>D50-W, where in measurement of a volume-based particle size distribution of the silver powder by a laser diffraction particle size distribution analysis, D50-IPA (?m) is a cumulative 50% point of particle diameter of the silver powder when isopropyl alcohol (IPA) is used as a measurement solvent for dispersing the silver powder, and D50-W (?m) is a cumulative 50% point of particle diameter of the silver powder when water is used as a measurement solvent for dispersing the silver powder, and wherein a phosphorus content in the silver powder is 0.01% by mass or more but 0.3% by mass or less.

Abstract: To provide a silver powder including alkenylsuccinic anhydride and/or alkenylsuccinic acid on a surface of the silver powder.

Abstract: An object of the present invention is to provide a method for producing a microcapsule formulation using a biodegradable polymer, the method being capable of avoiding direct contact of a peptidic physiologically active substance with an organic solvent layer, and achieving a high encapsulation efficiency of the peptidic physiologically active substance.

Abstract: A silver powder, wherein the silver powder satisfies D50-IPA>D50-W, where in measurement of a volume-based particle size distribution of the silver powder by a laser diffraction particle size distribution analysis, D50-IPA (?m) is a cumulative 50% point of particle diameter of the silver powder when isopropyl alcohol (IPA) is used as a measurement solvent for dispersing the silver powder, and D50-W (?m) is a cumulative 50% point of particle diameter of the silver powder when water is used as a measurement solvent for dispersing the silver powder, and wherein a phosphorus content in the silver powder is 0.01% by mass or more but 0.3% by mass or less.

Abstract: A reciprocating stirrer device with which favorable gas absorption into the stirred substance can be obtained. The reciprocating stirrer device is obtained from: a stirring vessel in which the substance to be stirred is placed; a reciprocating drive shaft provided inside the stirring vessel; a stirring blade connected and affixed so as to intersect the drive shaft; and a microbubble-generating unit. The microbubble-generating unit is obtained from a sparger that is made of a porous body and a gas supply means for supplying a gas to the sparger. Bubbles are generated in the substance being stirred by passing gas supplied to the sparger by the gas supply means through pores of the porous body.

Abstract: [Object] An object of the present invention is to provide a method for producing a microcapsule formulation using a biodegradable polymer, the method being capable of avoiding direct contact of a peptidic physiologically active substance with an organic solvent layer, and achieving a high encapsulation efficiency of the peptidic physiologically active substance.

Abstract: A support for enzyme immobilization is described, which is for immobilizing enzymes of various molecular sizes and also for, due to the modification of the surface silanol groups of porous silica particles, for immobilizing various kinds of enzymes, and enables the design of an immobilized enzyme, which exhibits an activity equivalent to that of the corresponding non-immobilized enzyme and withstands repeated use. A method for producing the support is also described. The support includes porous silica particles having an interparticle void structure therein, characterized in that the porous silica particles have a specific average particle size, a specific surface area, a specific pore volume, a specific pore size distribution and a specific porosity and have a substituent containing an organic group or an amino group on the surface thereof. An immobilized protein obtained by immobilizing a protein on the above support is also described.

Abstract: A method for culturing cells or microorganisms by dissolving oxygen or carbon dioxide in a culture solution containing a nutrient including: supplying gas containing oxygen or carbon dioxide into inside of a glass porous body being configured to have cylindrical shape and a large number of uniformly fine pores in the outer surface and being configured to seal the end of the glass porous body; generating bubbles that have a 50% diameter of 200 ?m or less in a volume-based particle size distribution from the outer surface of the porous body by using gas containing oxygen or carbon dioxide that is supplied from an unsealed end of the glass porous body; suppressing aggregation of the bubbles by at least one of a cell-protecting agent for protecting the cells and a protein hydrolysate included in the culture solution; and dissolving oxygen or carbon dioxide in the culture solution.

Abstract: Novel cellulose-producing bacteria including one capable of producing of a bacterial cellulose having a weight-average degree of polymerization in terms of polystyrene of 1.6×104 or above, one capable of producing a bacterial cellulose containing a small amount of the fraction with low degrees of polymerization, one producing a Bingham polysaccharide as a by-product, and one producing a small amount of water-soluble polysaccharide; a method for the production of bacterial cellulose, which comprises culturing these cellulose-producing bacteria; and bacterial cellulose thus obtained.

Abstract: An object of the present invention is to provide novel genes and gene group involved in cellulose synthesis of microorganisms. The present invention relates to a gene group encoding cellulase, cellulose synthase complex, &bgr;-glucosidase and the like, and to novel &bgr;-glucosidase.

Abstract: Novel cellulose-producing bacteria including one capable of producing of a bacterial cellulose having a weight-average degree of polymerization in terms of polystyrene of 1.6×104 or above, one capable of producing a bacterial cellulose containing a small amount of the fraction with low degrees of polymerization, one producing a Bingham polysaccharide as a by-product, and one producing a small amount of water-soluble polysaccharide; a method for the production of bacterial cellulose, which comprises culturing these cellulose-producing bacteria; and bacterial cellulose thus obtained.