Patents by Inventor Naoshi Nakagawa
Naoshi Nakagawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7358400Abstract: A method of industrially advantageously producing a cyclopropane monoacetal derivative represented by the formula (III) conveniently and also in a fewer steps by reacting a halogenated unsaturated carbonyl compound represented by the formula (II) with an alcoholate. wherein each symbol is as defined in the specification.Type: GrantFiled: March 25, 2005Date of Patent: April 15, 2008Assignees: Kuraray Co., Ltd., Daiichi Pharmaceutical Co., Ltd.Inventors: Kenichi Koyakumaru, Shingo Ueyama, Katsuji Ujita, Tatsuhiko Hayashibara, Naoshi Nakagawa, Toshifumi Akiba, Tatsuru Saito
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Publication number: 20070220262Abstract: An input assisting apparatus assists an input from a user. An input receiving unit receives the input from the user. An input-verification-data creating unit creates input verification data based on contents of the input received by the input receiving unit.Type: ApplicationFiled: September 18, 2006Publication date: September 20, 2007Applicant: FUJITSU LIMITEDInventors: Shigenari Suzuki, Kazufumi Nara, Kaoru Ota, Kazunori Nomura, Naoshi Nakagawa
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Publication number: 20070197490Abstract: The present invention relates to a method of producing a mixture of 5?-pregnane derivatives represented by the formula (II) and the formula (III), which is characterized by reacting a pregnane derivative represented by the formula (I) with a metal selected from alkali metals and alkaline earth metals in the presence of a proton donor and an amine and/or ammonia. According to the present invention, a method capable of producing 5?-pregnane derivatives useful as synthetic intermediates for squalamine, in a high yield from easily available raw materials, can be provided: wherein R1 is a hydroxyl-protecting group, and R2, R11 and R12 are each independently a hydrogen atom or a hydroxyl-protecting group.Type: ApplicationFiled: March 31, 2005Publication date: August 23, 2007Applicant: Kuraray Co., Ltd.Inventors: Kenichi Koyakumaru, Takashi Sugioka, Shigeo Ohzono, Naoshi Nakagawa
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Publication number: 20070191643Abstract: A method of industrially advantageously producing a cyclopropane monoacetal derivative represented by the formula (III) conveniently and also in a fewer steps by reacting a halogenated unsaturated carbonyl compound represented by the formula (II) with an alcoholate. wherein each symbol is as defined in the specification.Type: ApplicationFiled: March 25, 2005Publication date: August 16, 2007Applicants: Kuraray Co,, Ltd., Daiichi Pharmaceutical Co., Ltd.Inventors: Kenichi Koyakumaru, Shingo Ueyama, Katsuji Ujita, Tatsuhiko Hayashibara, Naoshi Nakagawa, Toshifumi Akiba, Tatsuru Saito
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Publication number: 20070149494Abstract: The present invention relates to a method of producing 5?-pregnane derivatives represented by the formula (II), which is characterized by reacting a pregnane derivative represented by the formula (I) with a metal selected from alkali metals and alkaline earth metals in the presence of a proton donor and an amine and/or ammonia. According to the present invention, a method capable of producing 5?-pregnane derivatives useful as synthetic intermediates for squalamine, in a high yield from easily available raw materials, can be provided: wherein R1 is a hydroxyl-protecting group, and R2, R11 and R12 are each independently a hydrogen atom or a hydroxyl-protecting group and R3 and R4 are each hydrogen atoms in combination form a bond.Type: ApplicationFiled: March 31, 2005Publication date: June 28, 2007Applicant: KURARAY CO., LTD.Inventors: Takashi Sugioka, Shigeo Ohzono, Kenichi Koyakumaru, Naoshi Nakagawa
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Patent number: 6288165Abstract: A process for producing vinyl acetate polymers comprises, after polymerization of at least one monomer comprising vinyl acetate, adding a conjugated polyene having a boiling point of at least 20° C. Saponified products of the vinyl acetate polymers obtained by this process can give molded articles causing little coloring and generation of gel-like agglomerates.Type: GrantFiled: December 5, 1997Date of Patent: September 11, 2001Assignee: Kuraray Co., Ltd.Inventors: Takeshi Moritani, Kaoru Ikeda, Akimasa Aoyama, Takaharu Kawahara, Yukihiro Ohara, Naoshi Nakagawa, Toshinori Tsugaru
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Patent number: 6007712Abstract: A waste water treatment apparatus which is compact, and excellent in durability, has a high treatment performance and can stably operate for a long time is provided. In a waste water treatment apparatus at least comprising a waste water treatment tank in which a carrier particle immobilizing a microbe is charged and decomposing and eliminating an organic matter and/or an inorganic matter contained in a waste water, and a membrane module for filtrating a water to be treated which flows out from said treatment tank, a non-permeating water not passing thorough the membrane module is returned and circulated to said treatment tank. In a waste water treatment apparatus at least comprising a waste water treatment tank in which a carrier particle immobilizing a microbe is charged and decomposing and eliminating an organic matter and/or an inorganic matter contained in a waste water, a carrier immobilizing a microbe is an acetalized polyvinyl alcohol hydrogel.Type: GrantFiled: February 25, 1998Date of Patent: December 28, 1999Assignee: Kuraray Co., Ltd.Inventors: Eiji Tanaka, Tamio Higashi, Takanori Kitamura, Takeshi Matsuda, Hiroaki Fujii, Naoshi Nakagawa, Shinji Komori, Tadao Shiotani, Masanobu Abe
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Patent number: 5744547Abstract: A process for producing vinyl acetate polymers comprises, after polymerization of at least one monomer comprising vinyl acetate, adding a conjugated polyene having a boiling point of at least 20.degree. C. Saponified products of the vinyl acetate polymers obtained by this process can give molded articles causing little coloring and generation of gel-like agglomerates.Type: GrantFiled: June 25, 1996Date of Patent: April 28, 1998Assignee: Kuraray Co., Ltd.Inventors: Takeshi Moritani, Kaoru Ikeda, Akimasa Aoyama, deceased, Takaharu Kawahara, Yukihiro Ohara, Naoshi Nakagawa, Toshinori Tsugaru
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Patent number: 5587486Abstract: 1-amino-2-cyclohexene compounds represented by the following formula (I): ##STR1## wherein the substituents are as defined in the specification, a process for preparing the compounds and their use as intermediates in the production of medicinal and agricultural agents is disclosed.Type: GrantFiled: June 30, 1995Date of Patent: December 24, 1996Assignee: Kuraray Co., Ltd.Inventors: Naoshi Nakagawa, Tadashi Hatanaka, Tatsuhiko Hayashibara, Manzo Shiono
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Patent number: 5494906Abstract: Vitamin D.sub.2 analogs in which a cyclopentane ring is introduced onto the 25-carbon of the side chain of 1.alpha.,25-dihydroxyvitamin D.sub.2 and its 24-epimer. The compounds are characterized by a marked intestinal calcium transport activity while exhibiting much lower activity than 1.alpha.,25-dihydroxyvitamin D.sub.3 in their ability to mobilize calcium from bone. Because of their preferential calcemic activity, these compounds would be useful for the treatment of diseases where bone formation is desired, such as osteoporosis.Type: GrantFiled: May 5, 1995Date of Patent: February 27, 1996Assignee: Wisconsin Alumni Research FoundationInventors: Hector F. DeLuca, Naoshi Nakagawa
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Patent number: 5478955Abstract: The invention is drawn to cholesterol derivatives in which a cyclopentane ring has been introduced onto the 25-carbon of the side chain and to 24-epimers of these compounds. The compounds are useful intermediates in the production of 26,27-dimethylene-1.alpha.,25-dihydroxyvitamin D.sub.2 and 26,27-dimethylene-24-epi-1.alpha.,25-dihydroxyvitamin D.sub.2. These vitamin D derivatives are useful for the treatment of diseases such as osteoporosis.Type: GrantFiled: November 10, 1994Date of Patent: December 26, 1995Assignee: Wisconsin Alumni Research FoundationInventors: Hector F. DeLuca, Naoshi Nakagawa
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Patent number: 5457217Abstract: Vitamin D.sub.2 analogs in which a cyclopentane ring is introduced into the side chain of 1.alpha.,25-dihydroxyvitamin D.sub.2. The compounds are characterized by a marked intestinal calcium transport activity while exhibiting much lower activity than 1.alpha.,25-dihydroxyvitamin D.sub.3 in their ability to mobilize calcium from bone. Because of their preferential calcemic activity, these compounds would be useful for the treatment of diseases where bone formation is desired, such as osteoporosis.Type: GrantFiled: December 9, 1994Date of Patent: October 10, 1995Assignee: Wisconsin Alumni Research FoundationInventors: Hector F. DeLuca, Naoshi Nakagawa
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Patent number: 5430873Abstract: During a software designing operation, a designer accesses a level prescribing unit through an interaction managing control unit. The level prescribing unit provides the guidance to specification information and design parts, etc. at a desired design level. If the designer selects and inputs specification information or design parts, the design editor corresponding to the design specification information in a design editor unit is activated, so that the designer is guided and aided through a display to produce a desired software. At this time, the information about the state of the editing operation "completed" or "not completed" is stored with the directory. The designed document satisfying a specific condition, for example, a document determined to be "design completed", is stored as a data base by a design data base storing unit.Type: GrantFiled: September 14, 1992Date of Patent: July 4, 1995Assignee: Fujitsu LimitedInventors: Hiroaki Abe, Itaru Fukao, Harumi Taneda, Yuji Kubota, Yasuhiko Arima, Naoshi Nakagawa, Takeo Konno, Yoshinori Arihara, Yuriko Suzuki
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Patent number: 5397775Abstract: Vitamin D.sub.2 analogs in which a cyclopentane ring is introduced onto the 25-carbon of the side chain of 1.alpha.,25-dihydroxyvitamin D.sub.2 and its 24-epimer. The compounds are characterized by a marked intestinal calcium transport activity while exhibiting much lower activity than 1.alpha.,25-dihydroxyvitamin D.sub.3 in their ability to mobilize calcium from bone. Because of their preferential calcemic activity, these compounds would be useful for the treatment of diseases where bone formation is desired, such as osteoporosis.Type: GrantFiled: June 2, 1993Date of Patent: March 14, 1995Assignee: Wisconsin Alumni Research FoundationInventors: Hector F. De Luca, Naoshi Nakagawa
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Patent number: 5373004Abstract: Vitamin D.sub.2 analogs in which a cyclopentane ring is introduced into the side chain of 1.alpha.,25-dihydroxyvitamin D.sub.2 The compounds are characterized by a marked intestinal calcium transport activity while exhibiting much lower activity than 1.alpha.,25-dihydroxyvitamin D.sub.3 in their ability to mobilize calcium from bone. Because of their preferential calcemic activity, these compounds would be useful for the treatment of diseases where bone formation is desired, such as osteoporosis.Type: GrantFiled: November 24, 1993Date of Patent: December 13, 1994Assignee: Wisconsin Alumni Research FoundationInventors: Hector F. DeLuca, Naoshi Nakagawa
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Patent number: 5359055Abstract: There are provided pregnane derivatives represented by formula ##STR1## wherein A.sup.1 represents a hydrogen atom or a hydroxyl group, A.sup.2 represents a substituent such as a hydroxyl group when A.sup.1 represents a hydrogen atom, or A.sup.2 represents a hydrogen atom when A.sup.1 represents a hydroxyl group, or A.sup.1 and A.sup.2 are combined together to form an oxo group; D.sup.1 represents a substituent such as a hydroxyl group, and D.sup.2 represents a hydrogen atom, or D.sup.1 and D.sup.2 are combined together to form an epoxy group or a single bond; D.sup.3, D.sup.5 and D.sup.7 each represents a hydrogen atom, D.sup.4 represents a hydroxyl group, and D.sup.6 represents a substituent such as a hydroxyl group, or D.sup.3 and D.sup.4 may be combined together to form an epoxy group or a single bond, or D.sup.4 and D.sup.5 may be combined together to form a single bond, or D.sup.5 and D.sup.6 may be combined together to form an epoxy group or a single bond, or D.sup.6 and D.sup.Type: GrantFiled: November 27, 1991Date of Patent: October 25, 1994Assignee: Kuraray Co., Ltd.Inventors: Jiro Tsuji, Takashi Takahashi, Masao Tsuji, Naoshi Nakagawa, Tetsuo Takigawa
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Patent number: 5218109Abstract: Steroid compounds of the following general formulas (I), (II) and (III) are provided: ##STR1## In the above formulas, R.sup.1 and R.sup.2 each is a hydrogen atom or a hydroxyl-protecting group, R is a group of the formula --CH.sub.2 --X (in which X is a substituent such as a hydroxyl group), a carboxyl group or a protected carboxyl group, A.sup.1 is an aryl group, a lower alkyl group or an aralkyl group, and Z.sup.1, Z.sup.2, Z.sup.3 and Z.sup.4 each is a hydrogen atom, a hydroxyl group or a protected hydroxyl group.The above steroid compounds are useful as intermediates for the synthesis of vitamin D.sub.3 derivatives having a hydroxyl group at the 1.alpha.-position.Type: GrantFiled: March 5, 1990Date of Patent: June 8, 1993Assignee: Kuraray Co., Ltd.Inventors: Jiro Tsuji, Takashi Takahashi, Masao Tsuji, Naoshi Nakagawa, Tetsuo Takigawa
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Patent number: 5194431Abstract: Vitamin D.sub.2 analogs in which a cyclopropane ring is introduced onto the 24-carbon of the side chain of 1.alpha.,25-dihydroxyvitamin D.sub.2 and 1.alpha.-hydroxyvitamin D.sub.2. The compounds are characterized by a marked intestinal calcium transport activity while exhibiting much lower activity than 1.alpha.,25-dihydroxy-vitamin D.sub.3 in their ability to mobilize calcium from bone. Because of their preferential calcemic activity, these compounds would be useful for the treatment of diseases where bone formation is desirbed, such as osteoporosis.Type: GrantFiled: July 8, 1992Date of Patent: March 16, 1993Assignee: Wisconsin Alumni Research FoundationInventors: Hector F. DeLuca, Naoshi Nakagawa
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Patent number: 5112998Abstract: There are provided pregnane derivatives represented by formula ##STR1## wherein A.sup.1 represents a hydrogen atom or a hydroxyl group, A.sup.2 represents a substituent such as a hydroxyl group when A.sup.1 represents a hydrogen atom, or A.sup.2 represents a hydrogen atom when A.sup.1 represents a hydroxyl group, or A.sup.1 and A.sup.2 are combined together to form an oxo group; D.sup.1 represents a substitutent such as a hydroxyl group, and D.sup.2 represents a hydrogen atom, or D.sup.1 and D.sup.2 are combined together to form an epoxy group or a single bond; D.sup.3, D.sup.5 and D.sup.7 each represents a hydrogen atom, D.sup.4 represents a hydroxyl group, and D.sup.6 represents a substitutent such as a hydroxyl group, or D.sup.3 and D.sup.4 may be combined together to form an epoxy group or a single bond, or D.sup.4 and D.sup.5 may be combined together to form a single bond, or D.sup.5 and D.sup.6 may be combined together to form an epoxy group or a single bond, or D.sup.6 and D.sup.Type: GrantFiled: June 15, 1990Date of Patent: May 12, 1992Assignee: Kuraray Co., Ltd.Inventors: Jiro Tsuji, Takashi Takahashi, Masao Tsuji, Naoshi Nakagawa, Tetsuo Takigawa
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Patent number: 4792615Abstract: A method of producing .alpha.-dihydropolyprenyl monophosphates from .alpha.-dihydropolyprenols through .alpha.-dihydropolyprenyl dichlorophosphates in good yield and with ease is provided. A method of producing .alpha.-dihydropolyprenyl dichlorophosphates which are intermediate compounds useful for the first-mentioned method is also provided.Type: GrantFiled: December 22, 1986Date of Patent: December 20, 1988Inventors: Naoshi Nakagawa, Tetsuo Takigawa, Akira Kageyu, Michiya Shimamura, Masafumi Okada, Masao Mizuno