Abstract: The present invention provides a gene encoding a protein from merozoite of Babesia caballi, a recombinant protein of Babesia caballi, and an antibody capable specifically binding to a 48 kDa protein of rhoptry of Babesia caballi merozoite. In accordance with the present invention, it is possible to stably prepare the 48 kDa protein of rhoptry of Babesia caballi and the gene encoding said protein in a large amount with the recombinant DNA technique. The present invention also provides a method for diagnosing equine babesiasis which comprises either specifically detecting anti-Babesia caballi antibody present in equine blood by using the recombinant protein of present invention as an antigen or detecting the presence of Babesia caballi merozoite in equine blood by using the antibody of the present invention.

Abstract: The invention relates to methods and devices for treating disorders with electric current or electric field therapy. The invention uses applied electric current or current induced by an external electric field to alter ionic concentrations and modulates at least one G-protein-coupled receptor. The invention is useful, for example, for treating hyperproliferative and cardiovascular disorders and for ameliorating the effects of stress.

Abstract: The present invention provides a gene encoding a protein from merozoite of Babesia caballi, a recombinant protein of Babesia caballi, and an antibody capable specifically binding to a 48 kDa protein of rhoptry of Babesia caballi merozoite. In accordance with the present invention, it is possible to stably prepare the 48 kDa protein of rhoptry of Babesia caballi and the gene encoding said protein in a large amount with the recombinant DNA technique. The present invention also provides a method for diagnosing equine babesiasis which comprises either specifically detecting anti-Babesia caballi antibody present in equine blood by using the recombinant protein of present invention as an .antigen or detecting the presence of Babesia caballi merozoite in equine blood by using the antibody of the present invention.

Abstract: The present invention provides a gene encoding a protein from merozoite of Babesia caballi, a recombinant protein of Babesia caballi, and an antibody capable specifically binding to a 48 kDa protein of rhoptry of Babesia caballi merozoite. In accordance with the present invention, it is possible to stably prepare the 48kDa protein of rhoptry of Babesia caballi and the gene encoding said protein in a large amount with the recombinant DNA technique. The present invention also provides a method for diagnosing equine babesiasis which comprises either specifically detecting anti-Babesia caballi antibody present in equine blood by using the recombinant protein of present invention as an antigen or detecting the presence of Babesia caballi merozoite in equine blood by using the antibody of the present invention.

Abstract: The invention relates to methods and devices for treating disorders with electric current or electric field therapy. The invention uses applied electric current or current induced by an external electric field to manipulate movement of ions across cell membranes and to alter ionic concentrations. The invention is useful, for example, for treating hyperproliferative and cardiovascular disorders and for ameliorating the effects of stress.

Abstract: A novel, substantially pure, physiologically active peptide is disclosed, comprising an amino acid sequence selected from Gly-Glu (SEQ ID NO. 5), Pro-Val-Val (SEQ ID NO. 6), Glu-Pro-Val-Val (SEQ ID NO. 7), Glu-Glu-Pro-Val-Val (SEQ ID NO. 8), Ala-Glu-Glu-Pro-Val-Val (SEQ ID NO. 9), and Gly-Ala-Glu-Glu-Pro-Val-Val (SEQ ID NO. 10). This peptide has immunoregulatory activities, including the activity to inhibit multiplication of Toxoplasma gondii inside cells, antibacterial activity, antiviral activity and antitumor activity. A composition comprising at least two peptides selected from the above peptides or comprising at least one peptide selected from the above peptides and at least one additional peptide comprising an amino acid sequence selected from Gly-Glu-Glu-Glu-Glu-Glu (SEQ ID NO. 1), Glu-Glu-Glu-Glu-Glu (SEQ ID NO. 2), Asp-Asp-Asp-Asp-Asp (SEQ ID NO. 3) and Ala-Glu-Glu-Glu-Glu-Glu (SEQ ID NO. 4) is especially useful as an active component for antiprotozoan, antibacterial, antiviral or antitumor agent.

Abstract: Biologically active peptides each having an activity to inhibit multiplication of toxoplasma and having a structure composed of amino acid sequence by the formula Gly-Glu-Glu-Glu-Glu-Glu; Glu-Glu-Glu-Glu-Glu; Asp-Asp-Asp-Asp-Asp; or Ala-Asp-Asp-Asp-Asp-Asp. These peptides are estimated to form active units or cores of Obioactin. The peptides may be applied in various dosage forms to human being and animals as immunoregulators against attack by toxoplasma, since they exhibit no specie specificity and have Toxo-GIF activities of 10 or more times on weight basis, and 40 or more time on molar basis, of that of the crude Obioactin.

Abstract: This invention relates to a biologically active substance which is a glycoprotein having a molecular weight of 3,000 to 5,000 and has activity to inhibit toxoplasma multiplication in homologous cells and heterologous cells.This invention also relates to a process for preparing the substance, immunoactive compositions containing the substance and use of the substance as a drug.

Abstract: This invention relates to a biologically active substance which is a glycoprotein having a molecular weight of 3,000 to 5,000 and has activity to inhibit toxoplasma multiplication in homologous cells and heterologous cells.This invention also relates to a process for preparing the substance, immunoactive compositions containing the substance and use of the substance as a drug.

Abstract: An air conditioning system particularly mounted in a passenger compartment of an automotive vehicle according to the present invention can be fixed in the maximum heating operation mode to produce a maximum effect of the defrosting function by only pushing a push-button switch engaged with a mode selector for maximizing the air blowing rate of a ventilating fan and also engaged with a three-way vacuum switch for opening a vacuum power servomechanism to the air to fix an air mix door in the maximum heating position.

Abstract: A vehicle mounted air conditioner controlling system is disclosed and of which system comprises a vacuum mode controlling switch (41) being controlled by depression of push-button switches (56) for each mode and mounted on a controller, a shift actuator (43) and vacuum selectors (42, 42'). The system is controlled by uni-directional vacuum signal and blower outlet doors and the air intake door are controlled by respective actuator provided individually therefor.

Abstract: An emergency controller for an air conditioning system of an automotive vehicle which incorporates an electronic control circuit in the automatic temperature adjusting means to perform a proportional control over an air mixing door by the use of a vacuum power servo is operated to connect a vacuum source to the vacuum power servo or to cause the air to flow into the vacuum power servo so that the maximum cooling or heating operation can be achieved. Consequently, when a trouble occurs in the electronic control circuit during running in a high-temperature region or low-temperature region, the air conditioning system may immediately be fixed in the maximum cooling or heating operation without intervention of electric circuits.

Abstract: An air conditioner of a vehicle having a selectively controlled conditioned air blowing outlet system using a shift actuator (20) equipped with a number of negative pressure supplying ports (a, b, c, d), in which selection of the operation mode of the conditioner is represented by the supply of a negative pressure signal to any one of the supplying ports, which causes displacement of a piston (31) of the shift actuator (20). The displacement is conveyed to selected one or more of doors provided at the outlets via a link mechanism to control the outlets according to a predetermined program.

Abstract: The present invention relates to a two position valve having a cam and a cam follower mechanism for holding the valve element in either of its two operative positions, depending on the operation of a push button switch arrangement cooperating with the valve so that the valve shifts between positions in response to pushing the switch. The cam takes the form of an arrowhead shaped groove having first and second apex portions in which the cam follower, a spring loaded pin, traces. The groove is formed with a step at one apex to prevent the pin from reversing its trace and to ensure its oneway tracing about the groove.

Abstract: An intake control system comprising a mode selector which receives a first control pressure and a second control pressure, and, according to the temperature inside and outside the vehicle, adapted to supply selectively a plurality of different combinations of the first and second control pressures to a pressure activated actuator to switch an air intake system between at least an outside air position and a recirculating air position. An air intake changeover switch receives the pressure output by an air control switch, a first reference pressure and a second reference pressure, and supplies a certain combination thereof as the first and second control pressures, when operated, to the mode selector, thereby causing the actuator to switch the air intake system to the recirculating air position, irrespective of the switching state of the mode selector.