Patents by Inventor Naoyuki Umetani

Naoyuki Umetani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USE OF ID4 FOR DIAGNOSIS AND TREATMENT OF CANCER
    Publication number: 20160122826
    Abstract: Methods for diagnosis and treatment of cancer using ID4 are disclosed. Specifically, epigenetic inactivation of ID4 in colorectal carcinomas and breast correlates with poor differentiation and unfavorable prognosis. Further, aberrant hypermethylation of ID4 gene promoter region increases risk of metastasis in colorectal and breast cancer.
    Type: Application
    Filed: May 4, 2015
    Publication date: May 5, 2016
    Inventors: Dave S.B. Hoon, Naoyuki Umetani
  • USE OF FREE CIRCULATING DNA FOR DIAGNOSIS, PROGNOSIS, AND TREATMENT OF CANCER
    Publication number: 20160115547
    Abstract: A method of detecting circulating DNA in a body fluid. The method comprises identifying a subject suffering from or at risk for developing cancer, obtaining a body fluid sample from the subject, and determining the sequence integrity of circulating DNA in the sample, wherein the circulating DNA is not purified from the sample.
    Type: Application
    Filed: June 26, 2015
    Publication date: April 28, 2016
    Inventors: Dave S.B. Hoon, Naoyuki Umetani, Eiji Sunami
  • Use of ID4 for Diagnosis and Treatment of Cancer
    Publication number: 20130345144
    Abstract: Methods for diagnosis and treatment of cancer using ID4 are disclosed. Specifically, epigenetic inactivation of ID4 in colorectal carcinomas and breast correlates with poor differentiation and unfavorable prognosis. Further, aberrant hypermethylation of ID4 gene promoter region increases risk of metastasis in colorectal and breast cancer.
    Type: Application
    Filed: August 7, 2009
    Publication date: December 26, 2013
    Applicant: JOHN WAYNE CANCER INSTITUTE
    Inventors: Dave S. B. Hoon, Naoyuki Umetani
  • USE OF ID4 FOR DIAGNOSIS AND TREATMENT OF CANCER
    Publication number: 20110098341
    Abstract: The invention relates to a method of determining whether a human subject is suffering from or at risk for developing pancreatic cancer by determining the methylation level of an ID4 gene promoter or the expression level of an ID4 gene in a biological sample from a human subject. Also disclosed are a method of analyzing the methylation level of an ID4 gene promoter or the expression level of an ID4 gene in a pancreatic cancer cell, and a method of inhibiting the methylation of an ID4 gene promoter or enhancing the expression of an ID4 gene by contacting a pancreatic cancer cell with a compound that decreases the methylation level of an ID4 gene promoter or increases the expression level of an ID4 gene in the cell.
    Type: Application
    Filed: December 23, 2010
    Publication date: April 28, 2011
    Inventors: Dave S.B. Hoon, Naoyuki Umetani
  • Use of ID4 for diagnosis and treatment of cancer
    Patent number: 7888033
    Abstract: The invention relates to a method of determining whether a human subject is suffering from or at risk for developing pancreatic cancer by determining the methylation level of an ID4 gene promoter or the expression level of an ID4 gene in a biological sample from a human subject. Also disclosed are a method of analyzing the methylation level of an ID4 gene promoter or the expression level of an ID4 gene in a pancreatic cancer cell, and a method of inhibiting the methylation of an ID4 gene promoter or enhancing the expression of an ID4 gene by contacting a pancreatic cancer cell with a compound that decreases the methylation level of an ID4 gene promoter or increases the expression level of an ID4 gene in the cell.
    Type: Grant
    Filed: April 2, 2009
    Date of Patent: February 15, 2011
    Assignee: John Wayne Cancer Institute
    Inventors: Dave S. B. Hoon, Naoyuki Umetani
  • USE OF FREE CIRCULATING DNA FOR DIAGNOSIS, PROGNOSIS, AND TREATMENT OF CANCER FUNDING
    Publication number: 20090280479
    Abstract: A method of detecting circulating DNA in a body fluid. The method comprises identifying a subject suffering from or at risk for developing cancer, obtaining a body fluid sample from the subject, and determining the sequence integrity of circulating DNA in the sample, wherein the circulating DNA is not purified from the sample.
    Type: Application
    Filed: May 30, 2006
    Publication date: November 12, 2009
    Applicant: JOHN WAYNE CANCER INSTITUTE
    Inventors: Dave S.B. Hoon, Naoyuki Umetani, Eiji Sunami
  • USE OF ID4 FOR DIAGNOSIS AND TREATMENT OF CANCER
    Publication number: 20090263812
    Abstract: The invention relates to a method of determining whether a human subject is suffering from or at risk for developing pancreatic cancer by determining the methylation level of an ID4 gene promoter or the expression level of an ID4 gene in a biological sample from a human subject. Also disclosed are a method of analyzing the methylation level of an ID4 gene promoter or the expression level of an ID4 gene in a pancreatic cancer cell, and a method of inhibiting the methylation of an ID4 gene promoter or enhancing the expression of an ID4 gene by contacting a pancreatic cancer cell with a compound that decreases the methylation level of an ID4 gene promoter or increases the expression level of an ID4 gene in the cell.
    Type: Application
    Filed: April 2, 2009
    Publication date: October 22, 2009
    Applicant: John Wayne Cancer Institute
    Inventors: Dave S.B. Hoon, Naoyuki Umetani
  • Use of ID4 for diagnosis and treatment of cancer
    Patent number: 7588894
    Abstract: Methods for diagnosis and treatment of cancer using ID4 are disclosed. Specifically, epigenetic inactivation of ID4 in colorectal carcinomas and breast correlates with poor differentiation and unfavorable prognosis. Further, aberrant hypermethylation of ID4 gene promoter region increases risk of metastasis in colorectal and breast cancer.
    Type: Grant
    Filed: February 1, 2006
    Date of Patent: September 15, 2009
    Assignee: John Wayne Cancern Institute
    Inventors: Dave S. B. Hoon, Naoyuki Umetani
  • Use of ID4 for diagnosis and treatment of cancer
    Publication number: 20070020646
    Abstract: Methods for diagnosis and treatment of cancer using ID4 are disclosed. Specifically, epigenetic inactivation of ID4 in colorectal carcinomas and breast correlates with poor differentiation and unfavorable prognosis. Further, aberrant hypermethylation of ID4 gene promoter region increases risk of metastasis in colorectal and breast cancer.
    Type: Application
    Filed: February 1, 2006
    Publication date: January 25, 2007
    Inventors: Dave Hoon, Naoyuki Umetani