Patents by Inventor Narasimha M. Vemuri

Narasimha M. Vemuri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • STABLE NON-HYGROSCOPIC CRYSTALLINE FORM OF N-[N-[N-(4-(PIPERIDIN-4-YL)BUTANOYL)-N-ETHYLGLYCYL]ASPARTYL]-L-&bgr;-CYCLOHEXYL ALANINE AMIDE, INTERMEDIATES THEREOF, AND PREPARATION THEREOF AND OF ANTITHROMBOTIC AZACYCLOALKYLALKANOYL PEPTIDES AND PSEUDOPEPTIDES
    Patent number: 6753409
    Abstract: The invention is directed to a non-hygroscopic stable crystalline form of the antithrombotic compound N-[N-[N-(4-piperdin-4-yl)butanoyl)-N-ethylglycyl]-(L)-aspartyl]-(L)-&bgr;-cyclohexyl-alanine amide, to processes for preparing said stable crystalline form, to a pharmaceutical composition thereof, and intermediates thereof, and the invention is directed also to processes for preparing a compound of the formula wherein: A, B, Z, E1, E2, G, R, m, n, and p are as defined herein.
    Type: Grant
    Filed: August 15, 2000
    Date of Patent: June 22, 2004
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Zofia J. Chrzan, James J. Mencel, David Toledo-Velasquez, Vincent Windisch, Rick G. Woodward, Diane C. Salazar, Narasimha M. Vemuri, Anthony J. Gardetto, Matthew R. Powers, Gregory G. Kubiak, Robert C. Liu, Benoit J. Vanasse, James P. Sherbine, Walter Rodriguez, Adam W. Sledeski
  • Milling process for the production of finely milled medicinal substances
    Patent number: 6641063
    Abstract: The invention is an improved method of generating fine medicament powders suitable for inhalation. A fluid energy mill is used with conventional milling fluids such as air or nitrogen. The milling fluid is treated to have a controlled relative humidity of between 30% and 70%. This produces a fine medicament powder with a median particle size below 10 micrometer but with little or no amorphous content generated during milling. Scale formation in the mill chamber is also greatly reduced.
    Type: Grant
    Filed: June 1, 2001
    Date of Patent: November 4, 2003
    Assignee: Aventis Pharma Limited
    Inventors: Narasimha M. Vemuri, Andrew B. Brown, Jean-Rene Authelin, Patrik Hosek
  • Milling process for the production of finely milled medicinal substances
    Publication number: 20020109025
    Abstract: The invention is an improved method of generating fine medicament powders suitable for inhalation. A fluid energy mill is used with conventional milling fluids such as air or nitrogen. The milling fluid is treated to have a controlled relative humidity of between 30% and 70%. This produces a fine medicament powder with a median particle size below 10 micrometer but with little or no amorphous content generated during milling. Scale formation in the mill chamber is also greatly reduced.
    Type: Application
    Filed: June 1, 2001
    Publication date: August 15, 2002
    Inventors: Narasimha M. Vemuri, Andrew B. Brown, Jean-Rene Authelin, Patrik Hosek
  • Stable non-hygroscopic crystalline form of N-[N-[N-4-(piperidin-4-yl)butanoyl)-N-ethylglycyl] aspartyl]-L-.beta.-cyclohexyl alanine amide
    Patent number: 6153588
    Abstract: The invention is directed to a non-hygroscopic stable crystalline form of the antithrombotic compound N-[N-[N-(4-piperdin-4-yl)butanoyl)-N-ethylglycyl]-(L)-aspartyl]-(L)-.beta. -cyclohexyl-alanine amide, to processes for preparing said stable crystalline form, to a pharmaceutical composition thereof, and intermediates thereof, and the invention is directed also to processes for preparing a compound of the formula ##STR1## wherein: A, B, Z, E.sup.1, E.sup.2, G, R, m, n, and p are as defined herein.
    Type: Grant
    Filed: February 18, 1999
    Date of Patent: November 28, 2000
    Assignee: Aventis Pharmaceuticals Products Inc.
    Inventors: Zofia J. Chrzan, James J. Mencel, David Toledo-Velasquez, Vincent Windisch, Rick G. Woodward, Diane C. Salazar, deceased, Narasimha M. Vemuri, Anthony J. Gardetto, Matthew R. Powers, Gregory G. Kubiak, Robert C. Liu, Benoit J. Vanasse, James P. Sherbine, Walter Rodriguez, Adam W. Sledeski