Patents by Inventor Narayanan Selvapalam
Narayanan Selvapalam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9073972Abstract: Provided is a method of separating cellular components, the method including: a) contacting a guest compound-bound reactive compound with cells; b) lysing the cells; c) adding a host compound-bound solid phase to a solution including the lysates of the cells to prepare a mixture; d) separating binding pairs of the guest compound bound to cellular components and the host compound bound to the solid phase from the mixture, and purifying the binding pairs; and e) separating the cellular components from the binding pairs, wherein the guest compound-bound reactive compound is obtained through a covalent bond between a reactive compound and a guest compound represented by Formula 2 below guest, the host compound-bound solid phase is obtained through a covalent bond between a solid phase and a host compound represented by Formula 1 below, and the reactive compound includes at least one selected from the group consisting of a biomolecule, N-hydroxysuccimide, an antigen, an antibody, an aptamer, folic acid, transferriType: GrantFiled: April 15, 2009Date of Patent: July 7, 2015Assignee: POSTECH ACADEMY-INDUSTRY FOUNDATIONInventors: Ki Moon Kim, Don Wook Lee, Sung Ho Ryu, Sang Hoon Ha, Hyun Tae Jung, Banerjee Mainak, Narayanan Selvapalam, Kyeng Min Park
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Patent number: 8513409Abstract: Inverted cucurbituril compounds having at least one pair of hydrogen atoms protruding into an internal molecular cavity thereof.Type: GrantFiled: July 24, 2006Date of Patent: August 20, 2013Assignees: University of Maryland, Pohang University of Science and TechnologyInventors: Kimoon Kim, Sang-Kyu Park, Young Ho Ko, Hyunuk Kim, Youngkook Kim, Narayanan Selvapalam, Lyle David Isaacs, Simin Liu
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Patent number: 8168436Abstract: The present invention provides a method for quantifying a peptide compound having a phenylalanine residue at the N-terminal, comprising measuring the content of heat generated by mixing 1) a peptide compound having a phenylalanine residue at the N-terminal, 2) cucurbit[7]uril, and 3) a metal ion in a solution.Type: GrantFiled: October 23, 2007Date of Patent: May 1, 2012Assignee: Japan Science and Technology AgencyInventors: Yoshihisa Inoue, Mikhail Rekharsky, Kimoon Kim, Yong Ho Ko, Narayanan Selvapalam
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Patent number: 8058451Abstract: Provided are hydroxycucurbituril derivatives, their preparation methods and uses. The hydroxycucurbituril derivative is easy to further functionalize with enhanced solubility in common solvents, thereby providing wider applications.Type: GrantFiled: June 13, 2008Date of Patent: November 15, 2011Assignee: Postech FoundationInventors: Ki-Moon Kim, Sang-Yong Jon, Narayanan Selvapalam, Dong-Hyun Oh
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Patent number: 8002987Abstract: Provided are a stationary phase and a column using a cucurbituril-bound silica gel, and a method of separating taxane using the column. The taxane separation method includes: preparing a column for taxane separation, the column being packed with a stationary phase including a cucurbituril-bound silica gel in which a cucurbituril represented by Formula 1 or 2 is covalently bound to a modified silica gel represented by Formula 3; dissolving a taxane powder in a solvent to prepare a taxane-containing solution; applying the taxane-containing solution to the column; supplying a mobile-phase solvent to the column to obtain a taxane extract from the column; and purifying taxane from the taxane extract. Therefore, highly purified taxane can be separated from a low-purity crude taxane extract.Type: GrantFiled: March 24, 2006Date of Patent: August 23, 2011Assignee: Postech Academy-Industry FoundationInventors: Kimoon Kim, Kyeng-Min Park, Young-Ho Ko, Narayanan Selvapalam, Erumaipatty R Nagarajan
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Patent number: 7993929Abstract: The present invention provides a method for determining in a pharmaceutical test formulation the presence or absence of a peptide compound PYY3-36 represented by the following amino acid sequence: H-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-X (SEQ ID NO: 1), wherein X is OH or a carboxy acid-protecting group, the method comprising (1) preparing a solution by mixing the pharmaceutical test formulation with cucurbit[7]uril in a solvent; and (2) thermally analyzing the solution prepared in Step (1).Type: GrantFiled: May 11, 2009Date of Patent: August 9, 2011Assignee: Japan Science and Technology AgencyInventors: Yoshihisa Inoue, Mikhail Rekharsky, Kimoon Kim, Yong Ho Ko, Narayanan Selvapalam
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Publication number: 20110092680Abstract: Provided is a method of separating cellular components, the method including: a) contacting a guest compound-bound reactive compound with cells; b) lysing the cells; c) adding a host compound-bound solid phase to a solution including the lysates of the cells to prepare a mixture; d) separating binding pairs of the guest compound bound to cellular components and the host compound bound to the solid phase from the mixture, and purifying the binding pairs; and e) separating the cellular components from the binding pairs, wherein the guest compound-bound reactive compound is obtained through a covalent bond between a reactive compound and a guest compound represented by Formula 2 below guest, the host compound-bound solid phase is obtained through a covalent bond between a solid phase and a host compound represented by Formula 1 below, and the reactive compound includes at least one selected from the group consisting of a biomolecule, N-hydroxysuccimide, an antigen, an antibody, an aptamer, folic acid, transferriType: ApplicationFiled: April 15, 2009Publication date: April 21, 2011Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATIONInventors: Ki Moon Kim, Don Wook Lee, Sung Ho Ryu, Sang Hoon Ha, Hyun Tae Jung, Banerjee Mainak, Narayanan Selvapalam, Kyeng Min Park
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Patent number: 7850992Abstract: Provided are a gel including a compound represented by Formula 1 below and a method of preparing the same: wherein n, X, A1, and A2 are as defined in the specification.Type: GrantFiled: October 25, 2006Date of Patent: December 14, 2010Assignees: Postech Academy-Industry Foundation, Postech FoundationInventors: Kimoon Kim, II Ha Hwang, Woo Sung Jeon, Hee Joon Kim, Dongwoo Kim, Narayanan Selvapalam, Erumaipatty R. Nagarajan
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Publication number: 20100281957Abstract: The present invention provides a method for determining in a pharmaceutical test formulation the presence or absence of a peptide compound PYY3-36 represented by the following amino acid sequence: H-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-X (SEQ ID NO: 1), wherein X is OH or a carboxy acid-protecting group, the method comprising (1) preparing a solution by mixing the pharmaceutical test formulation with cucurbit[7]uril in a solvent; and (2) thermally analyzing the solution prepared in Step (1).Type: ApplicationFiled: October 25, 2007Publication date: November 11, 2010Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCYInventors: Yoshihisa Inoue, Mikhail Rekharsky, Kimoon Kim, Yong Ho Ko, Narayanan Selvapalam
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Patent number: 7829698Abstract: Provided are nanoparticles prepared by the aggregation of cucurbituril derivatives and having a particle size of 1 to 1,000 nm, a pharmaceutical composition in which a pharmaceutically active substance is loaded into the nanoparticles, and preparation methods thereof.Type: GrantFiled: July 18, 2008Date of Patent: November 9, 2010Assignee: Postech FoundationInventors: Kimoon Kim, Sang Yong Jon, Young Jin Jeon, Dong Hyun Oh, Narayanan Selvapalam
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Publication number: 20100238969Abstract: The present invention provides a method for quantifying a peptide compound having a phenylalanine residue at the N-terminal, comprising measuring the content of heat generated by mixing 1) a peptide compound having a phenylalanine residue at the N-terminal, 2) cucurbit[7]uril, and 3) a metal ion in a solution.Type: ApplicationFiled: October 23, 2007Publication date: September 23, 2010Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCYInventors: Yoshihisa Inoue, Mikhail Rekharsky, Kimoon Kim, Yong Ho Ko, Narayanan Selvapalam
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Patent number: 7718128Abstract: Provided are a kit including a first component that is a compound of formula (1) below bound to a first material and a second component that is a ligand bound to a second material, wherein each of the first and second materials is independently selected from the group consisting of a solid phase, a biomolecule, an antioxidant, a chemical therapeutic agent, an anti-histaminic agent, a cucurbituril dendrimer, a cyclodextrin derivative, a crown ether derivative, a calixarene derivative, a cyclophane derivative, a cyclic peptide derivative, a metallic ion, a chromophore, a fluorescent material, a phosphor, a radioactive material, and a catalyst; and the ligand can non-covalently bind to the compound of formula (1); a method of separating and purifying a material bound to a ligand using the compound of formula (1) bound to a solid phase; a method of separating and purifying the compound of formula (1) or a material bound to the compound using a ligand bound to a solid phase; a sensor chip including a compound of fType: GrantFiled: December 19, 2008Date of Patent: May 18, 2010Assignee: Postech FoundationInventors: Kimoon Kim, Kangkyun Baek, Jeeyeon Kim, Ilha Hwang, Young Ho Ko, Narayanan Selvapalam, Erumaipatty R. Nagarajan, Kyeng Min Park
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Publication number: 20100009453Abstract: The present invention provides a method for determining in a pharmaceutical test formulation the presence or absence of a peptide compound PYY3-36 represented by the following amino acid sequence: H-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-X (SEQ ID NO: 1), wherein X is OH or a carboxy acid-protecting group, the method comprising (1) preparing a solution by mixing the pharmaceutical test formulation with cucurbit[7]uril in a solvent; and (2) thermally analyzing the solution prepared in Step (1).Type: ApplicationFiled: May 11, 2009Publication date: January 14, 2010Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCYInventors: Yoshihisa INOUE, Mikhail REKHARSKY, Kimoon KIM, Yong Ho KO, Narayanan SELVAPALAM
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Publication number: 20100010215Abstract: Inverted cucurbituril compounds having at least one pair of hydrogen atoms protruding into an internal molecular cavity thereof.Type: ApplicationFiled: July 24, 2006Publication date: January 14, 2010Applicant: THE UNIVERSITY OF MARYLANDInventors: Lyle David Isaacs, Simin Liu, Kimoon Kim, Sang-Kyu Park, Young Ho Ko, Hyunuk Kim, Youngkook Kim, Narayanan Selvapalam
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Publication number: 20090095677Abstract: Provided are a kit including a first component that is a compound of formula (1) below bound to a first material and a second component that is a ligand bound to a second material, wherein each of the first and second materials is independently selected from the group consisting of a solid phase, a biomolecule, an antioxidant, a chemical therapeutic agent, an anti-histaminic agent, a cucurbituril dendrimer, a cyclodextrin derivative, a crown ether derivative, a calixarene derivative, a cyclophane derivative, a cyclic peptide derivative, a metallic ion, a chromophore, a fluorescent material, a phosphor, a radioactive material, and a catalyst; and the ligand can non-covalently bind to the compound of formula (1); a method of separating and purifying a material bound to a ligand using the compound of formula (1) bound to a solid phase; a method of separating and purifying the compound of formula (1) or a material bound to the compound using a ligand bound to a solid phase; a sensor chip including a compound of fType: ApplicationFiled: December 19, 2008Publication date: April 16, 2009Applicants: POSTECH FOUNDATION, POSTECH ACADEMY-INDUSTRY FOUNDATIONInventors: Kimoon KIM, Kangkyun Baek, Jeeyeon Kim, Ilha Hwang, Young Ho Ko, Narayanan Selvapalam, Erumaipatty R. Nagarajan, Kyeng Min Park
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Patent number: 7479254Abstract: Provided are a kit including a first component that is a compound of formula (1) below bound to a first material and a second component that is a ligand bound to a second material, wherein each of the first and second materials is independently selected from the group consisting of a solid phase, a biomolecule, an antioxidant, a chemical therapeutic agent, an anti-histaminic agent, a cucurbituril dendrimer, a cyclodextrin derivative, a crown ether derivative, a calixarene derivative, a cyclophane derivative, a cyclic peptide derivative, a metallic ion, a chromophore, a fluorescent material, a phosphor, a radioactive material, and a catalyst; and the ligand can non-covalently bind to the compound of formula (1); a method of separating and purifying a material bound to a ligand using the compound of formula (1) bound to a solid phase; a method of separating and purifying the compound of formula (1) or a material bound to the compound using a ligand bound to a solid phase; a sensor chip including a compound of fType: GrantFiled: April 20, 2006Date of Patent: January 20, 2009Assignees: Postech Foundation, Postech Academy-Industry FoundationInventors: Kimoon Kim, Kangkyun Baek, Jeeyeon Kim, Iiha Hwang, Young Ho Ko, Narayanan Selvapalam, Erumaipatty R. Nagarajan, Kyeng Min Park
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Publication number: 20080290028Abstract: Provided are a stationary phase and a column using a cucurbituril-bound silica gel, and a method of separating taxane using the column. The taxane separation method includes: preparing a column for taxane separation, the column being packed with a stationary phase including a cucurbituril-bound silica gel in which a cucurbituril represented by Formula 1 or 2 is covalently bound to a modified silica gel represented by Formula 3; dissolving a taxane powder in a solvent to prepare a taxane-containing solution; applying the taxane-containing solution to the column; supplying a mobile-phase solvent to the column to obtain a taxane extract from the column; and purifying taxane from the taxane extract. Therefore, highly purified taxane can be separated from a low-purity crude taxane extract.Type: ApplicationFiled: March 24, 2006Publication date: November 27, 2008Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATIONInventors: Kimoon Kim, Young-Ho Ko, Kyeng-Min Park, Narayanan Selvapalam, Erumaipatty R. Nagarajan
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Publication number: 20080279950Abstract: Provided are nanoparticles prepared by the aggregation of cucurbituril derivatives and having a particle size of 1 to 1,000 nm, a pharmaceutical composition in which a pharmaceutically active substance is loaded into the nanoparticles, and preparation methods thereof.Type: ApplicationFiled: July 18, 2008Publication date: November 13, 2008Applicant: POSTECH FOUNDATIONInventors: Kimoon KIM, Sang Yong JON, Young Jin JEON, Dong Hyun OH, Narayanan SELVAPALAM
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Publication number: 20080264433Abstract: Provided is a cucurbituril-containing tobacco. The cucurbituril-containing tobacco includes a cucurbituril represented by Formula 1. The cucurbituril-containing tobacco can produce a reduced amount of harmful substances.Type: ApplicationFiled: March 9, 2006Publication date: October 30, 2008Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATIONInventors: Kimoon Kim, Kyeng-Min Park, Young-Ho Ko, Narayanan Selvapalam
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Publication number: 20080260676Abstract: Provided are hydroxycucurbituril derivatives, their preparation methods and uses. The hydroxycucurbituril derivative is easy to further functionalize with enhanced solubility in common solvents, thereby providing wider applications.Type: ApplicationFiled: June 13, 2008Publication date: October 23, 2008Applicant: POSTECH FOUNDATIONInventors: Kimoon KIM, Sang Yong JON, Narayanan SELVAPALAM, Dong Hyun OH