Patents by Inventor Narayanasamy Gurusamy
Narayanasamy Gurusamy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9040705Abstract: The present invention provides processes for the preparation of saturated ketone morphinan compounds. In particular, the invention provides processes for the conversion of a morphinan comprising an allyl alcohol ring moiety into a morphinan comprising a saturated ketone ring moiety by an isomerization reaction catalyzed by an inorganic salt of a late transition metal.Type: GrantFiled: April 9, 2010Date of Patent: May 26, 2015Assignee: Mallinckrodt LLCInventors: Peter X. Wang, Tao Jiang, Narayanasamy Gurusamy, Catherine K. Jung
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Publication number: 20100261907Abstract: The present invention provides processes for the preparation of saturated ketone morphinan compounds. In particular, the invention provides processes for the conversion of a morphinan comprising an allyl alcohol ring moiety into a morphinan comprising a saturated ketone ring moiety by an isomerization reaction catalyzed by an inorganic salt of a late transition metal.Type: ApplicationFiled: April 9, 2010Publication date: October 14, 2010Applicant: Mallinckrodt Inc.Inventors: Peter X. Wang, Tao Jiang, David W. Berberich, Narayanasamy Gurusamy, Catherine K. Jung
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Publication number: 20100228032Abstract: There is provided an improved and convenient process for the synthesis of aporphines, such as apomorphine and apocodeine, by the rearrangement of the corresponding morphine or codeine derivatives. The use of a suitable water scavenger in an acid catalyzed rearrangement of the morphine derivatives unexpectedly results in a reaction temperature convenient for plant operation without sacrificing product. The method of the present invention also alleviates the cumbersome operations that were employed in the prior art to eliminate water from the reaction mixture at the elevated temperatures. This process is adaptable for the general preparation of other aporphines from the corresponding morphine congeners.Type: ApplicationFiled: March 21, 2007Publication date: September 9, 2010Inventor: Narayanasamy Gurusamy
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Publication number: 20100216998Abstract: An improved method for producing apomorphine and derivatives thereof is provided. The method is a convenient ‘one-pot’ process, comprising the conversion of codeine into apomorphine without isolating the apocodeine intermediate. Use of water reactive scavengers, reagents that will react irreversibly with water, decreases side product formation and allows the use of milder reaction conditions. This one-pot synthesis of apomorphine from codeine provides a faster reaction with improved yields at temperatures lower as compared to conventional methods. The lower operating temperatures and less volatile reactants make the method particularly useful for large-scale manufacturing.Type: ApplicationFiled: September 2, 2008Publication date: August 26, 2010Applicant: MALLINCKRODT INC.Inventor: Narayanasamy Gurusamy
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Publication number: 20090258843Abstract: The present invention is directed to compositions and methods for the treatment of various diseases, pathological disorders, and medical conditions such as viral infections and cancer. The compositions include (A) an antiviral compound or a pharmaceutically acceptable salt thereof; and (B) an agent selected from the group consisting of a substituted or unsubstituted imidazole or a pharmaceutically acceptable salt thereof; a non-steroidal anti-inflammatory agent or a pharmaceutically acceptable salt thereof; an amino acid or a pharmaceutically acceptable salt thereof; a carboxylic acid or a pharmaceutically acceptable salt thereof; a sulfonic acid or a pharmaceutically acceptable salt thereof; and a combination thereof.Type: ApplicationFiled: April 8, 2009Publication date: October 15, 2009Applicant: Mallinckrodt Inc.Inventors: Gary L. Cantrell, Robert E. Halvachs, Narayanasamy Gurusamy, Dawn M. Kyle, Frank W. Moser
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Patent number: 5254776Abstract: Bromobiphenyls (such as 2-fluoro-4-bromobiphenyl) are synthesized by reacting together a phenylboronic acid (such as phenylboronic acid) and a bromoiodobenzene (such as 2-fluoro-4-bromoiodobenzene). The reaction generally takes place with the aid of a catalyst (such as palladium in a zero valance state) and an inert solvent (such as fluorobenzene). Control of temperature is very important to obtain both an acceptable reaction rate and an acceptable level of terphenyl byproduct.Type: GrantFiled: July 17, 1992Date of Patent: October 19, 1993Assignee: Mallinckrodt Specialty Chemicals CompanyInventors: John F. Lang, Narayanasamy Gurusamy
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Patent number: 5149875Abstract: Aromatic amine compounds are halogenated in the presence of a quaternary ammonium halide.Type: GrantFiled: January 15, 1991Date of Patent: September 22, 1992Assignee: Mallinckrodt Specialty Chemicals CompanyInventors: Jerry R. Patton, Narayanasamy Gurusamy
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Patent number: 5053542Abstract: A process for the production of 2,4-dihaloaniline, especially 4-bromo-2-fluoroaniline, via the halogenation (bromination) of 2-haloaniline (2-fluoroaniline) in the presence of quaternary ammonium halide (bromide) catalyst in an inert solvent. The yield and selectivity are very high and the inventive method includes continuous processing with recycle of the catalyst/solvent mixture.Type: GrantFiled: January 31, 1990Date of Patent: October 1, 1991Assignee: Mallinckrodt Specialty Chemicals CompanyInventors: Jerry R. Patton, Narayanasamy Gurusamy
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Patent number: 4996355Abstract: The present invention comprises compounds of the formulas: ##STR1## wherein X is Cl or Br. These compounds are useful as intermediaries for the production of 2,4,5-trifluorobenzoic acid and 2,4,5-trifluorobenzoyl fluoride.Type: GrantFiled: April 14, 1989Date of Patent: February 26, 1991Assignee: Mallinckrodt, Inc.Inventor: Narayanasamy Gurusamy
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Patent number: 4992564Abstract: Disclosed is a practical and efficient process for preparing 6-substituted 4-chromanones from phenolic acrylate ester compounds derivable from para-substituted phenolic or thiophenolic compounds and beta-unsubstituted acrylic acid compounds which are esterifiable therewith. The process includes effecting rearrangement of a phenolic or thiophenolic acrylate ester in the presence of a rearrangement effective amount of hydrogen fluoride to the corresponding hydroxy--or mercapto (vinyl ketone) wherein the carbonyl carbon atom of the vinyl carboxy group is directly attached to the benzene ring ortho to the hydroxy or mercapto group. Thereafter, the vinyl ketone is cyclized to the corresponding 6-substituted 4-chromanone in the presence of a cyclization-effective amount of hydrogen fluoride. The 6-substituted 4-chromanones prepared by the process are useful as intermediates for preparing pharmaceutical agents.Type: GrantFiled: August 31, 1989Date of Patent: February 12, 1991Assignee: Mallinckrodt, Inc.Inventors: Jerry R. Patton, Narayanasamy Gurusamy
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Patent number: 4918203Abstract: Disclosed is a practical and efficient process for preparing 6-substituted 4-chromanones from phenolic acrylate ester compounds derivable from para-substituted phenolic or thiophenolic compounds and beta-unsubstituted acrylic acid compounds which are esterifiable therewith. The process includes effecting rearrangement of a phenolic or thiophenolic acrylate ester in the presence of a rearrangement effective amount of hydrogen fluoride to the corresponding hydroxy - or mercapto (vinyl ketone) wherein the carbonyl carbon atom of the vinyl carboxy group is directly attached to the benzene ring ortho to the hydroxy or mercapto group. Thereafter, the vinyl ketone is cyclized to the corresponding 6-substituted 4-chromanone in the presence of a cyclization-effective amount of hydrogen fluoride. The 6-substituted 4-chromanones prepared by the process are useful as intermediates for preparing pharmaceutical agents.Type: GrantFiled: February 3, 1988Date of Patent: April 17, 1990Assignee: Mallinckrodt Inc.Inventors: Jerry R. Patton, Narayanasamy Gurusamy