Patents by Inventor Narutoshi HIBINO
Narutoshi HIBINO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230157755Abstract: Provided herein are methods of generating optimized models of vascular grafts for subjects in certain embodiments. Methods of treating subjects in need of vascular grafts are also provided. Related systems and computer program products are additionally provided.Type: ApplicationFiled: March 23, 2021Publication date: May 25, 2023Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: Byeol KIM, Xiaolong LIU, Axel KRIEGER, Mark D. FUGE, Phong Danh NGUYEN, Rachel HESS, Pratham Vijay NAR, Laura OLIVIERI, Narutoshi HIBINO, Yue-Hin LOKE, Paige MASS, Seda ASLAN
-
Publication number: 20230107620Abstract: It has been established that optimizing cell seeding onto tissue engineering vascular grafts (TEVG) is associated with reduced inflammatory responses and reduced post-operative stenosis of TEVG. Cell seeding increased TEVG patency in a dose dependent manner, and TEVG patency improved when more cells were seeded, however duration of incubation time showed minimal effect on TEVG patency. Methods of engineering patient specific TEVG including optimal numbers of cells to maintain graft patency and reduce post-operative stenosis are provided. Closed, single-use customizable systems for seeding TEVG are also provided. Preferably the systems are custom-designed based on morphology of the patient specific graft, to enhance the efficacy of cell seeding.Type: ApplicationFiled: December 8, 2022Publication date: April 6, 2023Inventors: Christopher Breuer, Robert Strouse, Yong Ung-Lee, Cameron Best, Narutoshi Hibino
-
Patent number: 11541149Abstract: It has been established that optimizing cell seeding onto tissue engineering vascular grafts (TEVG) is associated with reduced inflammatory responses and reduced post-operative stenosis of TEVG. Cell seeding increased TEVG patency in a dose dependent manner, and TEVG patency improved when more cells were seeded, however duration of incubation time showed minimal effect on TEVG patency. Methods of engineering patient specific TEVG including optimal numbers of cells to maintain graft patency and reduce post-operative stenosis are provided. Closed, single-use customizable systems for seeding TEVG are also provided. Preferably the systems are custom-designed based on morphology of the patient specific graft, to enhance the efficacy of cell seeding.Type: GrantFiled: December 12, 2016Date of Patent: January 3, 2023Assignee: Research Institute at Nationwide Children's HospitalInventors: Christopher Breuer, Cameron Best, Robert Strouse, Narutoshi Hibino, Yong Ung-Lee
-
Publication number: 20220186055Abstract: Provided are compositions (which may inks), methods, devices, and systems that are used with 3D printing. The compositions contain fluoropolymer particles, one or more type of a medium, one or more surfactants, and one or more shear thinning agents. The fluoropolymer component can be one or more of polytetrafluoroethylene (PTFE), perfluoroalkoxy, fluorinated ethylene-propylene, and poly ethyl enetetrafluoroethylene. Cartridges that contain the compositions are also provided. Methods of making the compositions, methods of using the compositions for 3D printing, and articles of manufacture, such as medical devices, are also provided.Type: ApplicationFiled: April 19, 2020Publication date: June 16, 2022Inventors: Zhouran Jiang, Devina Chatterjee, Galip Ozan Erol, David H. Gracias, Sung Hoon Kang, Lewis Romer, Narutoshi Hibino
-
Publication number: 20210238266Abstract: Excessive or repeated activation of inflammatory and pro-coagulant mechanisms at the site of tissue injury contributes to the development scar tissue that can lead to intimal hyperplasia and fibrotic disease. It has been established that inhibition of the LYST protein is associated with reduced inflammatory responses and reduced platelet activation at the site of tissue damage. Compositions and methods for inhibition of the expression and function of the LYST protein are described. The compositions and methods can be useful for the modulation of immune processes that contribute to formation of neointima and fibroproliferative disorders by altering macrophage, platelet and natural killer cell function to create a pro-regenerative immune response.Type: ApplicationFiled: November 13, 2020Publication date: August 5, 2021Inventors: Christopher Breuer, Narutoshi Hibino, Vidu Garg, Cameron Best
-
Patent number: 10895020Abstract: A method for generating a electro spun fiber medical implant including determining dimensions of a portion of anatomy of a patient corresponding to the electro spun fiber medical implant via medical imaging, generating a model of the portion of the anatomy based on the dimensions, the model including one or more solid areas and one or more void areas encompassed within the one or more solid areas, inverting the model to generate a mandrel model, the mandrel model generated based on the one or more void areas, generating the mandrel based on the mandrel model, the mandrel including at least one electrically conductive material therein, and applying an electro-spinning process to the mandrel to generate the electro spun fiber medical implant which circumscribes the mandrel, wherein the mandrel is removable from within the electro spun fiber medical implant after a disassembly process.Type: GrantFiled: August 26, 2016Date of Patent: January 19, 2021Assignees: CHILDREN'S NATIONAL MEDICAL CENTER, RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL, NANOFIBER SOLUTIONS LLCInventors: Axel Krieger, Narutoshi Hibino, Jed Johnson, Justin Opfermann, Carolyn Cochenour Dorgan, Christopher K. Breuer
-
Publication number: 20180353649Abstract: It has been established that optimizing cell seeding onto tissue engineering vascular grafts (TEVG) is associated with reduced inflammatory responses and reduced post-operative stenosis of TEVG. Cell seeding increased TEVG patency in a dose dependent manner, and TEVG patency improved when more cells were seeded, however duration of incubation time showed minimal effect on TEVG patency. Methods of engineering patient specific TEVG including optimal numbers of cells to maintain graft patency and reduce post-operative stenosis are provided. Closed, single-use customizable systems for seeding TEVG are also provided. Preferably the systems are custom-designed based on morphology of the patient specific graft, to enhance the efficacy of cell seeding.Type: ApplicationFiled: December 12, 2016Publication date: December 13, 2018Applicant: Research Institute at Nationwide Children's HospitalInventors: Christopher Breuer, Cameron Best, Robert Strouse, Narutoshi Hibino, Yong Ung-Lee
-
Publication number: 20180245243Abstract: A method for generating a electro spun fiber medical implant including determining dimensions of a portion of anatomy of a patient corresponding to the electro spun fiber medical implant via medical imaging, generating a model of the portion of the anatomy based on the dimensions, the model including one or more solid areas and one or more void areas encompassed within the one or more solid areas, inverting the model to generate a mandrel model, the mandrel model generated based on the one or more void areas, generating the mandrel based on the mandrel model, the mandrel including at least one electrically conductive material therein, and applying an electro-spinning process to the mandrel to generate the electro spun fiber medical implant which circumscribes the mandrel, wherein the mandrel is removable from within the electro spun fiber medical implant after a disassembly process.Type: ApplicationFiled: August 26, 2016Publication date: August 30, 2018Applicants: CHILDREN'S NATIONAL MEDICAL CENTER, RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL, NANOFIBER SOLUTIONSInventors: Axel KRIEGER, Narutoshi HIBINO, Jed JOHNSON, Justin OPFERMANN, Carolyn COCHENOUR, Christopher K. BREUER
-
Patent number: 10034960Abstract: A composition including PPF or a PPF copolymer that can be used to fabricate biodegradable structures. The composition can be used in 3-D patterning (e.g., 3-D printing and sterolighography) methods. For example, 3-D patternable compositions include PPF or a PPF copolymer, a photoinitiator or photoinitiators, and a resolution control inhibitor or inhibitors. The compositions can be used to make biodegradable structures (such as cardivascular scaffolds). The biodegradable structures can be surface functionalized. The biodegradable structures can be used in methods of blood delivery in an individual.Type: GrantFiled: June 6, 2014Date of Patent: July 31, 2018Assignee: University of Maryland, College ParkInventors: John Patrick Fisher, Anthony Melchiorri, Narutoshi Hibino, Axel Krieger, John P. Costello, Carolyn Cochenour
-
Publication number: 20170073401Abstract: Excessive or repeated activation of inflammatory and pro-coagulant mechanisms at the site of tissue injury contributes to the development scar tissue that can lead to intimal hyperplasia and fibrotic disease. It has been established that inhibition of the LYST protein is associated with reduced inflammatory responses and reduced platelet activation at the site of tissue damage. Compositions and methods for inhibition of the expression and function of the LYST protein are described. The compositions and methods can be useful for the modulation of immune processes that contribute to formation of neointima and fibroproliferative disorders by altering macrophage, platelet and natural killer cell function to create a pro-regenerative immune response.Type: ApplicationFiled: May 4, 2015Publication date: March 16, 2017Inventors: Christopher Breuer, Narutoshi Hibino, Vidu Garg, Cameron Best
-
Publication number: 20160136326Abstract: A composition including PPF or a PPF copolymer that can be used to fabricate biodegradable structures. The composition can be used in 3-D patterning (e.g., 3-D printing and sterolighography) methods. For example, 3-D patternable compositions include PPF or a PPF copolymer, a photoinitiator or photoinitiators, and a resolution control inhibitor or inhibitors. The compositions can be used to make biodegradable structures (such as cardivascular scaffolds). The biodegradable structures can be surface functionalized. The biodegradable structures can be used in methods of blood delivery in an individual.Type: ApplicationFiled: June 6, 2014Publication date: May 19, 2016Inventors: John Patrick FISHER, Anthony MELCHIORRI, Narutoshi HIBINO, Axel KRIEGER, John P. COSTELLO, Carolyn COCHENOUR