Abstract: Human antibodies immunospecific for human CD27 are capable of blocking CD27 binding to its ligand CD70 and neutralizing bioactivity of CD27 including, but not limited to, CD27 intracellular signaling, T-cell proliferation and activation, B-cell proliferation and differentiation, plasmablast formation and alleviation of antibody responses, stimulation of tumor cells by CD70, and the production of soluble mediators from T and B-cells. The antibodies are useful in diagnosing or treating CD27 activity associated diseases and conditions.

Abstract: A method of making an optical fibre preform comprising providing a hollow outer tube of glass, providing a hollow primary capillary tube of glass with an outer diameter smaller than an inner diameter of the outer tube, positioning the primary capillary tube inside the outer tube such that an outer surface of the primary capillary tube lies against an inner surface of the outer tube along a contact line parallel to the longitudinal axes of the primary capillary tube and the outer tube, and bonding the primary capillary tube into its position inside the outer tube by directing a laser beam onto a surface of the outer tube or the primary capillary at one or more locations aligned with the contact line.

Abstract: A hollow core optical waveguide comprises a hollow core; and a structured arrangement of longitudinally extending capillaries surrounding the hollow core to form a cladding; wherein one or both of the hollow core and the cladding contains gas configured to provide a refractive index difference between the hollow core and the cladding.

Abstract: A preform (10) for an antiresonant hollow core optical fibre comprises an outer jacket tube (12) having an inner surface and a central longitudinal axis (24); a plurality of antiresonant cladding tubes (14) spaced apart at predefined peripheral locations around the inner surface of the outer jacket tube (12), each antiresonant cladding tube (14) in contact with the inner surface such that a central longitudinal axis (26) of each antiresonant cladding tube (14) is at a first radial distance from the central longitudinal axis (24) of the outer jacket tube (12); and a plurality of spacing elements (22) disposed alternately with the antiresonant cladding tubes (14) and each in contact with an outer surface of each of two adjacent antiresonant cladding tubes (14) at one or more contact points (28), the contact points (28) at a second radial distance from the central longitudinal axis (24) of the outer jacket tube (12), the second radial distance being greater than the first radial distance.

Abstract: A preform (10) for an antiresonant hollow core optical fibre comprises an outer jacket tube (12) having an inner surface and a central longitudinal axis (24); a plurality of antiresonant cladding tubes (14) spaced apart at predefined peripheral locations around the inner surface of the outer jacket tube (12), each antiresonant cladding tube (14) in contact with the inner surface such that a central longitudinal axis (26) of each antiresonant cladding tube (14) is at a first radial distance from the central longitudinal axis (24) of the outer jacket tube (12); and a plurality of spacing elements (22) disposed alternately with the antiresonant cladding tubes (14) and each in contact with an outer surface of each of two adjacent antiresonant cladding tubes (14) at one or more contact points (28), the contact points (28) at a second radial distance from the central longitudinal axis (24) of the outer jacket tube (12), the second radial distance being greater than the first radial distance.

Abstract: A method of making an optical fibre preform comprising providing a hollow outer tube of glass, providing a hollow primary capillary tube of glass with an outer diameter smaller than an inner diameter of the outer tube, positioning the primary capillary tube inside the outer tube such that an outer surface of the primary capillary tube lies against an inner surface of the outer tube along a contact line parallel to the longitudinal axes of the primary capillary tube and the outer tube, and bonding the primary capillary tube into its position inside the outer tube by directing a laser beam onto a surface of the outer tube or the primary capillary at one or more locations aligned with the contact line.