Abstract: The invention relates to bacterial strains, particularly for use in the field of vaccines, in particular to the field of the prevention or treatment of infections caused by bacterium of the Bordetella genus.

Abstract: The present invention relates to the field of immunogenic compositions and vaccines and the use of such compositions in medicine. More particularly, it relates to immunogenic fragments of UspA2 comprising an epitope and immunogenic compositions and vaccines comprising said fragments, for use in preventing or treating an infection, disease or condition caused by heterologous strain(s) of Moraxella catarrhalis. The invention further relates to immunogenic compositions and vaccines comprising an immunogenic fragment wherein said fragment comprises an epitope with cross-bactericidal activity.

Abstract: Compositions and methods for the treatment or prevention of Gram-negative bacterial strain infection are provided herein. Methods for the manufacture of said compositions are also provided herein.

Abstract: The present disclosure relates to the field of Neisserial immunogenic compositions and vaccines, their manufacture and the use of such compositions in medicine. In particular the present invention relates to compositions and methods involving the factor H binding protein (fHbp) antigen. The present inventors have recognised that fHbp is poorly expressed in neisserial strains of ST269 clonal complex (a subset of strains which seems to be growing in terms of numbers of reported cases of disease attributed to it), and vaccines comprising fHbp may be made more effective against said strains by formulating the vaccine with a further antigen that can elicit protection against these strains.

Abstract: Compositions and methods for the treatment or prevention of Gram-negative bacterial strain infection are provided herein. Methods for the manufacture of said compositions are also provided herein.

Abstract: Compositions for the treatment or prevention of Neisserial infection and methods for their use and manufacture are provided herein.

Abstract: Compositions and methods for the treatment or prevention of Gram-negative bacterial strain infection are provided herein. Methods for the manufacture of said compositions are also provided herein.

Abstract: Compositions for the treatment or prevention of Neisserial infection and methods for their use and manufacture are provided herein.

Abstract: Immunogenic compositions and methods of their use, as well as processes for their production are provided herein.

Abstract: Compositions and methods for the treatment or prevention of Gram-negative bacterial strain infection are provided herein. Methods for the manufacture of said compositions are also provided herein.

Abstract: Neisserial immunogenic compositions and vaccines, their manufacture and methods for the use of such compositions in medicine are provided herein.

Abstract: The present invention relates to a method of LOS molecular typing of a Neisseria strain by determining the presence of a functional gene and/or gene product of one or more genes involved in the biosynthesis of LOS.