Patents by Inventor Nathan Brinkman

Nathan Brinkman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of treatment using hemopexin compositions
    Patent number: 10918696
    Abstract: The present invention relates generally to a method of purifying proteins. More specifically, the present inventions relates to a method of purifying haptoglobin and hemopexin from the same starting material, and uses thereof.
    Type: Grant
    Filed: March 5, 2018
    Date of Patent: February 16, 2021
    Assignee: CSL BEHRING AG
    Inventor: Nathan Brinkman
  • HEMOPEXIN FORMULATIONS
    Publication number: 20200237652
    Abstract: The present invention relates generally to a stable liquid formulation of purified hemopexin comprising: (a) a hemopexin content of at least 50 mg/mL; (b) at least 15 mM phosphate buffer; (c) a pH from 5.8 to 8; and (d) at least 50 mM sodium chloride; and uses thereof.
    Type: Application
    Filed: August 8, 2018
    Publication date: July 30, 2020
    Inventors: Thomas GENTINETTA, Nathan BRINKMAN, David BOEREMA, Bo AN, Kyle MINER
  • METHODS OF TREATMENT USING HEMOPEXIN COMPOSITIONS
    Publication number: 20190038712
    Abstract: The present invention relates generally to a method of purifying proteins. More specifically, the present inventions relates to a method of purifying haptoglobin and hemopexin from the same starting material, and uses thereof.
    Type: Application
    Filed: March 5, 2018
    Publication date: February 7, 2019
    Inventor: Nathan BRINKMAN
  • Methods of treatment using hemopexin compositions
    Patent number: 9937229
    Abstract: The present invention relates generally to a method of purifying proteins. More specifically, the present inventions relates to a method of purifying haptoglobin and hemopexin from the same starting material, and uses thereof.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: April 10, 2018
    Assignee: CSL Behring AG
    Inventor: Nathan Brinkman
  • METHODS OF TREATMENT USING HEMOPEXIN COMPOSITIONS
    Publication number: 20170072011
    Abstract: The present invention relates generally to a method of purifying proteins. More specifically, the present inventions relates to a method of purifying haptoglobin and hemopexin from the same starting material, and uses thereof.
    Type: Application
    Filed: November 22, 2016
    Publication date: March 16, 2017
    Inventor: Nathan BRINKMAN
  • Method of purifying proteins
    Patent number: 9534029
    Abstract: The present invention relates generally to a method of purifying proteins. More specifically, the present inventions relates to a method of purifying haptoglobin and hemopexin from the same starting material, and uses thereof.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: January 3, 2017
    Assignee: CSL Behring AG
    Inventor: Nathan Brinkman
  • Methods for purification of alpha-1-antitrypsin and apolipoprotein A-1
    Patent number: 8962802
    Abstract: This invention relates to protein separation and purification methods for both alpha-1-antitrypsin (AAT, also known as alpha-1 proteinase inhibitor, API, and A.sub.1-PI) and Apolipoprotein A-I (ApoA-1) from, for example, a fraction of human blood plasma. In certain embodiments, the invention provides methods for separating AAT from ApoA-1 at the initial stage of purification, so that the same starting material can be used as a source for both proteins. The methods further pertain to providing compositions of AAT and of ApoA-1 suitable for pharmaceutical use and are suitable for large-scale purification.
    Type: Grant
    Filed: December 3, 2013
    Date of Patent: February 24, 2015
    Assignee: CSL Behring GmbH
    Inventors: Nathan Brinkman, Douglas Bigler, Reinhard Bolli, Vreni Foertsch
  • METHODS FOR PURIFICATION OF ALPHA-1-ANTITRYPSIN AND APOLIPOPROTEIN A-1
    Publication number: 20140094591
    Abstract: This invention relates to protein separation and purification methods for both alpha-1-antitrypsin (AAT, also known as alpha-1 proteinase inhibitor, API, and A.sub.1-PI) and Apolipoprotein A-I (ApoA-1) from, for example, a fraction of human blood plasma. In certain embodiments, the invention provides methods for separating AAT from ApoA-1 at the initial stage of purification, so that the same starting material can be used as a source for both proteins. The methods further pertain to providing compositions of AAT and of ApoA-1 suitable for pharmaceutical use and are suitable for large-scale purification.
    Type: Application
    Filed: December 3, 2013
    Publication date: April 3, 2014
    Applicant: CSL Behring GmbH
    Inventors: Nathan Brinkman, Douglas Bigler, Reinhard Bolli, Vreni Foertsch
  • Methods for purification of alpha-1-antitrypsin and apolipoprotein A-1
    Patent number: 8653245
    Abstract: This invention relates to protein separation and purification methods for both alpha-1-antitrypsin (AAT, also known as alpha-1 proteinase inhibitor, API, and A.sub.1-PI) and Apolipoprotein A-I (ApoA-1) from, for example, a fraction of human blood plasma. In certain embodiments, the invention provides methods for separating AAT from ApoA-1 at the initial stage of purification, so that the same starting material can be used as a source for both proteins. The methods further pertain to providing compositions of AAT and of ApoA-1 suitable for pharmaceutical use and are suitable for large-scale purification.
    Type: Grant
    Filed: April 5, 2013
    Date of Patent: February 18, 2014
    Assignee: CSL Behring GmbH
    Inventors: Nathan Brinkman, Douglas Bigler, Reinhard Bolli, Vreni Foertsch
  • Methods for purification of alpha-1-antitrypsin andapolipoprotein A-1
    Patent number: 8436152
    Abstract: This invention relates to protein separation and purification methods for both alpha-1-antitrypsin (AAT, also known as alpha-1 proteinase inhibitor, API, and A1-PI) and Apolipoprotein A-I (ApoA-I) from, for example, a fraction of human blood plasma. In certain embodiments, the invention provides methods for separating AAT from ApoA-I at the initial stage of purification, so that the same starting material can be used as a source for both proteins. The methods further pertain to providing compositions of AAT and of ApoA-I suitable for pharmaceutical use and are suitable for large-scale purification.
    Type: Grant
    Filed: August 15, 2008
    Date of Patent: May 7, 2013
    Assignee: CSL Behring GmbH
    Inventors: Nathan Brinkman, Douglas Bigler, Reinhard Bolli, Vreni Foertsch
  • METHODS FOR PURIFICATION OF ALPHA-1-ANTITRYPSIN ANDAPOLIPOPROTEIN A-1
    Publication number: 20110087008
    Abstract: This invention relates to protein separation and purification methods for both alpha-1-antitrypsin (AAT, also known as alpha-1 proteinase inhibitor, API, and A1-PI) and Apolipoprotein A-I (ApoA-1) from, for example, a fraction of human blood plasma. In certain embodiments, the invention provides methods for separating AAT from ApoA-1 at the initial stage of purification, so that the same starting material can be used as a source for both proteins. The methods further pertain to providing compositions of AAT and of ApoA-1 suitable for pharmaceutical use and are suitable for large-scale purification.
    Type: Application
    Filed: August 15, 2008
    Publication date: April 14, 2011
    Inventors: Nathan Brinkman, Douglas Bigler, Reinhard Bolli, Vreni Foertsch