Abstract: The disclosure provides processes for synthesizing compounds for use as CFTR modulators.

Abstract: A smart temperature control system is disclosed. The smart temperature control system includes processing circuitry and a temperature control device. The temperature control device includes a container configured to store a product and temperature control hardware configured to control a temperature within the container. The processing circuitry includes one or more processors configured to monitor the temperature cycles within the container, determine a duration of at least portions of each temperature cycle over a time period, determine a selected time value based on the duration of the portions of each temperature cycle, and update a time limit variable with the selected time value.

Abstract: An online agricultural system manages and optimizes interactions of entities within the system to enable the execution of transaction and the transportation of crop products. The online agricultural system accesses historic and environmental data describing factors that may impact crop product transactions and/or transportation to determine market prices for crop products and crop product transportation. Responsive to receiving a request from an entity, the online agricultural system determines an optimal transaction for the entity, such as a price for selling a crop product, an available crop product for purchase, or a transportation opportunity to transport a crop product.

Abstract: A co-injection hot runner nozzle comprises an inner melt flow channel and an annular outer melt flow channel that surrounds the inner melt flow channel. The inner and outer melt flow channels have a first common source. The nozzle further comprises an annular intermediate melt flow channel disposed between the inner and outer melt flow channels. The annular intermediate melt flow channel is at least partly defined by a plurality of spiral grooves, each spiral groove having a respective inlet and defining a helical flow path. Lands between adjacent spiral grooves increase in clearance in a downstream direction. An annular axial flow path is defined over the lands. A plurality of feeder channels having a second common source is configured to supply melt to the plurality of inlets of the spiral grooves. The relationship of feeder channels to spiral grooves may be one-to-one. The inlets may be longitudinal channels.

Abstract: A co-injection hot runner nozzle comprises an inner melt flow channel and an annular outer melt flow channel that surrounds the inner melt flow channel. The inner and outer melt flow channels have a first common source. The nozzle further comprises an annular intermediate melt flow channel disposed between the inner and outer melt flow channels. The annular intermediate melt flow channel is at least partly defined by a plurality of spiral grooves, each spiral groove having a respective inlet and defining a helical flow path. Lands between adjacent spiral grooves increase in clearance in a downstream direction. An annular axial flow path is defined over the lands. A plurality of feeder channels having a second common source is configured to supply melt to the plurality of inlets of the spiral grooves. The relationship of feeder channels to spiral grooves may be one-to-one. The inlets may be longitudinal channels.

Abstract: Disclosed is a system which assists rescuers in efforts to locate persons in the event of potentially harmful condition in a structure. An example system includes a sensory node which gathers sensor data including occupancy data. The system uses the sensory node to gather and process condition data to establish normal behavioral characteristics of the data. Threshold levels are determined from this processing. An alert is transmitted when conditions are detected that fall outside those threshold levels. The alert includes information regarding the detected conditions, occupancy information, and structure data. An example system includes a portable device that receives the alert along with the information provided with the alert and uses that information to alert a user and provide a display that provides alert and occupancy data such that occupants of the structure can be located and provided with assistance if required.

Abstract: A method includes receiving data from a sensor over time. The data comprises a plurality of values that are each indicative of a sensed condition at a unique time. The method also includes determining a real-time value, a mid-term moving average, and a long-term moving average based on the data and determining a most-recent combined average by averaging the real-time value, the mid-term moving average, and the long-term moving average. The method further includes determining an upper setpoint by adding an offset value to the most-recent combined average and determining a lower setpoint by subtracting the offset value to the most-recent combined average. The method also includes transmitting an alert based on a determination that a most recent value of the data is either greater than the upper setpoint or lower than the lower setpoint.

Abstract: A co-injection hot runner nozzle comprises an inner melt flow channel and an annular outer melt flow channel that surrounds the inner melt flow channel. The inner and outer melt flow channels have a first common source. The nozzle further comprises an annular intermediate melt flow channel disposed between the inner and outer melt flow channels. The annular intermediate melt flow channel is at least partly defined by a plurality of spiral grooves, each spiral groove having a respective inlet and defining a helical flow path. Lands between adjacent spiral grooves increase in clearance in a downstream direction. An annular axial flow path is defined over the lands. A plurality of feeder channels having a second common source is configured to supply melt to the plurality of inlets of the spiral grooves. The relationship of feeder channels to spiral grooves may be one-to-one. The inlets may be longitudinal channels.

Abstract: A pylon assembly for a tiltrotor aircraft includes a fixed pylon having an outboard end. A rotor assembly is rotatably coupled to the fixed pylon and is operable to rotate between a a vertical takeoff and landing orientation and a forward flight orientation. The rotor assembly includes a proprotor operable to produce a slipstream. A wing extension is rotatably coupled to the outboard end of the fixed pylon. The wing extension is operable to rotate generally with the rotor assembly such that a minimal dimension of the wing extension remains in the slipstream of the proprotor.

Abstract: A pylon assembly for a tiltrotor aircraft includes a fixed pylon having an outboard end. A rotor assembly is rotatably coupled to the fixed pylon and is operable to rotate between a a vertical takeoff and landing orientation and a forward flight orientation. The rotor assembly includes a proprotor operable to produce a slipstream. A wing extension is rotatably coupled to the outboard end of the fixed pylon. The wing extension is operable to rotate generally with the rotor assembly such that a minimal dimension of the wing extension remains in the slipstream of the proprotor.

Abstract: A pylon assembly for a tiltrotor aircraft includes a fixed pylon having an outboard end. A rotor assembly is rotatably coupled to the fixed pylon and is operable to rotate between a generally vertical orientation in a vertical takeoff and landing mode and a generally horizontal orientation in a forward flight mode. The rotor assembly includes a proprotor operable to produce a generally vertical slipstream in the vertical takeoff and landing mode and a generally horizontal slipstream in the forward flight mode. A wing extension is rotatably coupled to the outboard end of the fixed pylon. The wing extension is operable to rotate generally with the rotor assembly such that a minimal dimension of the wing extension remains in the slipstream of the proprotor.

Abstract: A pylon assembly for a tiltrotor aircraft includes a fixed pylon having an outboard end. A rotor assembly is rotatably coupled to the fixed pylon and is operable to rotate between a generally vertical orientation in a vertical takeoff and landing mode and a generally horizontal orientation in a forward flight mode. The rotor assembly includes a proprotor operable to produce a generally vertical slipstream in the vertical takeoff and landing mode and a generally horizontal slipstream in the forward flight mode. A wing extension is rotatably coupled to the outboard end of the fixed pylon. The wing extension is operable to rotate generally with the rotor assembly such that a minimal dimension of the wing extension remains in the slipstream of the proprotor.

Abstract: An illustrative apparatus includes a protective housing and a recording device. The protective housing can include a water-resistant layer comprising a material that is impervious to water. The water-resistant layer can define an inside space of the protective housing. The protective housing can also include a fire-resistant layer that surrounds the water-resistant layer and an outside layer that surrounds the fire-resistant layer. The recording device within the inside space can include a transceiver configured to receive sensed data from one or more sensory nodes and from a commercial panel of a building, a memory configured to store the data received by the transceiver, and a processor operatively coupled to the transceiver and the memory. The processor can be configured to publish the sensed data such that the sensed data is accessible to a first responder.

Abstract: A method includes receiving data from a sensor over time. The data comprises a plurality of values that are each indicative of a sensed condition at a unique time. The method also includes determining a real-time value, a mid-term moving average, and a long-term moving average based on the data and determining a most-recent combined average by averaging the real-time value, the mid-term moving average, and the long-term moving average. The method further includes determining an upper setpoint by adding an offset value to the most-recent combined average and determining a lower setpoint by subtracting the offset value to the most-recent combined average. The method also includes transmitting an alert based on a determination that a most recent value of the data is either greater than the upper setpoint or lower than the lower setpoint.

Abstract: An illustrative apparatus includes a protective housing and a recording device. The protective housing can include a water-resistant layer comprising a material that is impervious to water. The water-resistant layer can define an inside space of the protective housing. The protective housing can also include a fire-resistant layer that surrounds the water-resistant layer and an outside layer that surrounds the fire-resistant layer. The recording device within the inside space can include a transceiver configured to receive sensed data from one or more sensory nodes and from a commercial panel of a building, a memory configured to store the data received by the transceiver, and a processor operatively coupled to the transceiver and the memory. The processor can be configured to publish the sensed data such that the sensed data is accessible to a first responder.

Abstract: A method includes receiving data from a sensor over time. The data comprises a plurality of values that are each indicative of a sensed condition at a unique time. The method also includes determining a real-time value, a mid-term moving average, and a long-term moving average based on the data and determining a most-recent combined average by averaging the real-time value, the mid-term moving average, and the long-term moving average. The method further includes determining an upper setpoint by adding an offset value to the most-recent combined average and determining a lower setpoint by subtracting the offset value to the most-recent combined average. The method also includes transmitting an alert based on a determination that a most recent value of the data is either greater than the upper setpoint or lower than the lower setpoint.

Abstract: An illustrative apparatus includes a protective housing and a recording device. The protective housing can include a water-resistant layer comprising a material that is impervious to water. The water-resistant layer can define an inside space of the protective housing. The protective housing can also include a fire-resistant layer that surrounds the water-resistant layer and an outside layer that surrounds the fire-resistant layer. The recording device within the inside space can include a transceiver configured to receive sensed data from one or more sensory nodes and from a commercial panel of a building, a memory configured to store the data received by the transceiver, and a processor operatively coupled to the transceiver and the memory. The processor can be configured to publish the sensed data such that the sensed data is accessible to a first responder.

Abstract: A method includes receiving, by a user device, information regarding a sensed condition in a structure, wherein the sensed condition is sensed by a sensory node. The method also includes generating, by the user device, a notification to a user of the user device, where the notification identifies the sensed condition. The method also includes determining, by the user device, whether the sensed condition exceeds a threshold. The method further includes identifying one or more actions that can be performed by the user in response to the sensed condition, where the one or more actions are based at least in part on the determining of whether the sensed condition exceeds the threshold.

Abstract: A system, apparatus and method for identifying states or types of individual objects within a class of objects of interest are provided. A supervised algorithm is executed on a set of map data to separate a class of objects of interest from other objects. An unsupervised algorithm is executed to identify different types or states of individual objects within the class of objects of interest identified by the supervised algorithm. The results are then stored on a non-transitory storage medium.