Patents by Inventor Nathan Knotts

Nathan Knotts has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USE OF CANCER CELL EXPRESSION OF CADHERIN 12 AND CADHERIN 18 TO TREAT MUSCLE INVASIVE AND METASTATIC BLADDER CANCERS
    Publication number: 20240115699
    Abstract: We combined single nuclei RNA sequencing with spatial transcriptomics and single-cell resolution spatial proteomic analysis of human bladder cancer to identify an epithelial subpopulation with therapeutic response prediction ability. These cells express Cadherin 12 (CDH12, N-Cadherin 2), catenins, and other epithelial markers. CDH12-enriched tumors define patients with poor outcome following surgery with or without neoadjuvant chemotherapy (NAC), whereas CDH12-enriched tumors have a superior response to immune checkpoint therapy (ICT). Patient stratification by tumor CDH12 enrichment offered better prediction outcome than established bladder cancer subtypes. The CDH12 population resembles an undifferentiated state with chemoresistance. CDH12-enriched cells express PD-L1 and PD-L2 and co-localize with exhausted T-cells, possibly mediated through CD49a (ITGA1), likely explaining ICT efficacy in these tumors.
    Type: Application
    Filed: June 6, 2022
    Publication date: April 11, 2024
    Applicant: Cedars-Sinai Medical Center
    Inventors: Dan Theodorescu, Simon Knott, Kenneth Gouin, Nathan Ing, Charles Rosser
  • Lubricant for percussion equipment
    Patent number: 8822393
    Abstract: This invention discloses a lubricant suitable for use in percussion equipment. The lubricant comprises a base oil selected from the group consisting of Group I or Group II, blended in a synergistic amount with a gear oil package and a friction modifier. The lubricant exhibits superior wear and superior extreme pressure properties due to the synergistic effect of the gear oil package and the friction modifier. In a preferred embodiment, the gear oil package comprises a polyalkyl methacrylate polymer, and the friction modifier comprises a synthetic ester.
    Type: Grant
    Filed: November 17, 2011
    Date of Patent: September 2, 2014
    Assignee: Chevron U.S.A. Inc.
    Inventors: Nathan Knotts, Allan George Hee
  • LUBRICANT FOR PERCUSSION EQUIPMENT
    Publication number: 20120129745
    Abstract: This invention discloses a lubricant suitable for use in percussion equipment. The lubricant comprises a base oil selected from the group consisting of Group I or Group II, blended in a synergistic amount with a gear oil package and a friction modifier. The lubricant exhibits superior wear and superior extreme pressure properties due to the synergistic effect of the gear oil package and the friction modifier. In a preferred embodiment, the gear oil package comprises a polyalkyl methacrylate polymer, and the friction modifier comprises a synthetic ester.
    Type: Application
    Filed: November 17, 2011
    Publication date: May 24, 2012
    Applicant: Chevron U.S.A. Inc.
    Inventors: Nathan Knotts, Allan George Hee