Patents by Inventor Nathan Roth
Nathan Roth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 9299534Abstract: A defining aperture plate having at least two differently sized apertures is used in conjunction with at least two charge collectors. Because of the difference in aperture width, the two charge collectors receive different amounts of ions, where the amount is proportional to the associated aperture width. By monitoring the ratio of the charge collected by the first charge collector to the charge collected by the second collector, the amount of erosion can be monitored and optionally compensated for.Type: GrantFiled: January 31, 2014Date of Patent: March 29, 2016Assignee: Varian Semiconductor Equipment Associates, Inc.Inventors: David Timberlake, Mark R. Amato, Nathan Roth
-
Publication number: 20150221472Abstract: A defining aperture plate having at least two differently sized apertures is used in conjunction with at least two charge collectors. Because of the difference in aperture width, the two charge collectors receive different amounts of ions, where the amount is proportional to the associated aperture width. By monitoring the ratio of the charge collected by the first charge collector to the charge collected by the second collector, the amount of erosion can be monitored and optionally compensated for.Type: ApplicationFiled: January 31, 2014Publication date: August 6, 2015Inventors: David Timberlake, Mark R. Amato, Nathan Roth
-
Patent number: 9023797Abstract: Described herein are methods for inactivating viruses using caprylate in solutions containing albumin.Type: GrantFiled: July 25, 2013Date of Patent: May 5, 2015Assignee: Grifols, S.A.Inventors: Wytold Lebing, Doug Burns, Nathan Roth, Joann Hotta
-
Publication number: 20140163101Abstract: Described herein are methods for inactivating viruses using caprylate in solutions containing albumin.Type: ApplicationFiled: July 25, 2013Publication date: June 12, 2014Applicant: GRIFOLS, S.A.Inventors: Wytold Lebing, Doug Burns, Nathan Roth, Joann Hotta
-
Patent number: 6333050Abstract: The present invention is directed to an oral active agent delivery system and method for delivering discrete units of an active agent formulation to a patient. An active agent formulation chamber containing the active agent formulation and having a fluid passing active agent formulation retainer is placed at a first end into a fluid and at a second end into a patient's mouth. The active agent is delivered when the patient sips on the second end of the chamber.Type: GrantFiled: January 19, 2001Date of Patent: December 25, 2001Assignee: Alza CorporationInventors: Patrick S.-L. Wong, Howard B. Rosen, Nathan Roth, Phyllis I. Gardner
-
Publication number: 20010002262Abstract: The present invention is directed to an oral active agent delivery system and method for delivering discrete units of an active agent formulation to a patient. An active agent formulation chamber containing the active agent formulation and having a fluid passing active agent formulation retainer is placed at a first end into a fluid and at a second end into a patient's mouth. The active agent is delivered when the patient sips on the second end of the chamber.Type: ApplicationFiled: January 19, 2001Publication date: May 31, 2001Inventors: Patrick S. L. Wong, Howard B. Rosen, Nathan Roth, Phyllis I. Gardner
-
Patent number: 6224908Abstract: Oral active agent delivery system having improved flow controllers. A hollow tubular member containing the active agent formulation and having a fluid passing controller is placed at one end into a fluid and at a second end into a patient's mouth. The active agent is delivered when the patient sips on the end of the chamber. The improved controllers prevent leakage of the active agent formulation.Type: GrantFiled: May 24, 2000Date of Patent: May 1, 2001Assignee: Alza CorporationInventors: Patrick S.-L. Wong, Vincent J. Ferrari, Jeffrey W. Etter, Miriam A. Martin, Nathan Roth, Christopher M. G. Ohms, Andrew I. Poutiatine, James Horvath
-
Patent number: 6210713Abstract: The present invention is an oral active agent delivery system and method for delivering discrete units of an active agent formulation to a patient. An active agent formulation chamber containing the active agent formulation and having a fluid passing active agent formulation retainer is placed at a first end into a fluid and at a second end into a patient's mouth. The active agent is delivered when the patient sips on the second end of the chamber.Type: GrantFiled: February 25, 2000Date of Patent: April 3, 2001Assignee: Alza CorporationInventors: Patrick S.-L. Wong, Howard B. Rosen, Nathan Roth, Phyllis I. Gardner
-
Patent number: 6139878Abstract: A method using diafiltration to prepare a blood product is described. The method removes contaminating plasma proteins from whole blood or blood products. Diafiltration may be used on paraformaldehyde-fixed platelets to remove formaldehyde to undetectable levels, and to suspend the platelets into a formulation buffer suitable for subsequent treatment, such as lyophilization. The manufacturing procedure can be divided into three steps, a first diafiltration, fixation, preferably with paraformaldehyde, and a second diafiltration. In the first step, plasma proteins are removed from fresh or stored platelets or blood cells. The technique is gentle to prevent the activation and aggregation of the platelets. Fixation stabilizes the platelets to withstand freezing, lyophilization and subsequent reconstitution, and also provides a viral and bacterial reduction.Type: GrantFiled: April 27, 1998Date of Patent: October 31, 2000Assignee: Aventis Behring, LLCInventors: Louis Summaria, Nathan Roth, Aberash Berhe, Mark Even
-
Patent number: 6106845Abstract: The present invention is directed to an oral active agent delivery system and method for delivering discrete units of an active agent formulation to a patient. An active agent formulation chamber containing the active agent formulation and having a fluid passing active agent formulation retainer is placed at a first end into a fluid and at a second end into a patient's mouth. The active agent is delivered when the patient sips on the second end of the chamber.Type: GrantFiled: April 27, 1999Date of Patent: August 22, 2000Assignee: ALZA CorporationInventors: Patrick S. -L. Wong, Howard B. Rosen, Nathan Roth, Phyllis I. Gardner
-
Patent number: 6103265Abstract: The present invention is directed to an oral active agent delivery system comprising improved flow controllers. A hollow tubular member (10) containing the active agent formulation and having a fluid passing controller (14) is placed at one end (16) into a fluid and at a second end (18) into a patient's mouth. The active agent is delivered when the patient sips on the end of the chamber. The improved controllers prevent leakage of the active agent formulation.Type: GrantFiled: September 22, 1999Date of Patent: August 15, 2000Assignee: ALZA CorporationInventors: Patrick S.-L. Wong, Vincent J. Ferrari, Jeffrey W. Etter, Miriam A. Martin, Nathan Roth, Christopher M. G. Ohms, Andrew I. Poutiatine, James Horvath
-
Patent number: 5989590Abstract: The present invention is directed to an oral active agent delivery system and method for delivering discrete units of an active agent formulation to a patient. An active agent formulation chamber containing the active agent formulation and having a fluid passing active agent formulation retainer is placed at one end into a fluid and at a second end into a patient's mouth. The active agent is delivered when the patient sips on the end of the chamber.Type: GrantFiled: June 19, 1998Date of Patent: November 23, 1999Assignee: Alza CorporationInventors: Patrick S.-L. Wong, Howard B. Rosen, Nathan Roth, Phyllis I. Gardner
-
Patent number: 5985324Abstract: The present invention is directed to an oral active agent delivery system comprising improved flow controllers. A hollow tubular member (10) containing the active agent formulation and having a fluid passing controller (14) is placed at one end (16) into a fluid and at a second end (18) into a patient's mouth. The active agent is delivered when the patient sips on the end of the chamber. The improved controllers prevent leakage of the active agent formulation.Type: GrantFiled: May 7, 1998Date of Patent: November 16, 1999Assignee: ALZA CorporationInventors: Patrick S.-L. Wong, Vincent J. Ferrari, Jeffrey W. Etter, Miriam A. Martin, Nathan Roth, Christopher M. G. Ohms, Andrew I. Poutiatine, James Horvath
-
Patent number: 5910321Abstract: The present invention is directed to an oral active agent delivery system and method for delivering discrete units of an active agent to a patient. An elongate tubular member having first and second ends comprises first and second flow paths. Either or both of said flow paths contains an active agent. Liquid is drawn up into the first end of the member, and the liquid and active agent is drawn out of the second end of the member and into the patient's mouth.Type: GrantFiled: October 14, 1997Date of Patent: June 8, 1999Assignee: Alza CorporationInventors: Patrick S.-L. Wong, Nathan Roth, Vincent J. Ferrari
-
Patent number: 5780058Abstract: The present invention is directed to an oral active agent delivery system and method for delivering discrete units of an active agent formulation to a patient. An active agent formulation chamber (10) containing the active agent formulation and having a fluid passing active agent formulation retainer (14) is placed at one end (16) into a fluid and at a second end (18) into a patient's mouth. The active agent is delivered when the patient sips on the end of the chamber.Type: GrantFiled: July 19, 1996Date of Patent: July 14, 1998Assignee: ALZA CorporationInventors: Patrick S.-L. Wong, Howard B. Rosen, Nathan Roth, Phyllis I. Gardner
-
Patent number: 5320598Abstract: A dry-state iontophoretic drug delivery device (10, 70, 80) is provided. The device has drug and electrolyte reservoirs (15, 16) which are initially in a non-hydrated condition. A liquid-containing pouch (21, 22) is provided. In certain embodiments the liquid is contained in breakable capsules within the pouch. Water or other liquid can be released from the capsules in the pouch by squeezing or flexing the pouches (21,22). Alternatively, the liquid can be released from the pouches (21,22) using pouch piercing pins (36,37). The liquid released from the pouches (21,22) hydrates the drug and electrolyte reservoirs (15, 16) and activates the device. In another embodiment, the device (20, 20a) has liquid-containing gel layers (31,32) which are initially separated from their respective electrode assemblies (8, 9). Liquid-wicking pathways (27,28) are provided to carry the liquid from the gel layers (31,32) to the drug and electrolyte layers (15, 16).Type: GrantFiled: May 12, 1992Date of Patent: June 14, 1994Assignee: ALZA CorporationInventors: Ronald P. Haak, J. Richard Gyory, Felix Theeuwes, Felix A. Landrau, Nathan Roth, Robert M. Myers
-
Patent number: 5288289Abstract: A dry-state iontophoretic drug delivery device (10, 70, 80) is provided. The device has drug and electrolyte reservoirs (15, 16) which are initially in a non-hydrated condition. A liquid-containing pouch (21, 22) is provided. In certain embodiments the liquid is contained in breakable capsules within the pouch. Water or other liquid can be released from the capsules in the pouch by squeezing or flexing the pouches (21,22). Alternatively, the liquid can be released from the pouches (21,22) using pouch piercing pins (36,37). The liquid released from the pouches (21,22) hydrates the drug and electrolyte reservoirs (15, 16) and activates the device. In another embodiment, the device (20, 20a) has liquid-containing gel layers (31,32) which are initially separated from their respective electrode assemblies (8, 9). Liquid-wicking pathways (27,28) are provided to carry the liquid from the gel layers (31,32) to the drug and electrolyte layers (15, 16).Type: GrantFiled: May 12, 1992Date of Patent: February 22, 1994Assignee: ALZA CorporationInventors: Ronald P. Haak, J. Richard Gyory, Felix Theeuwes, Felix A. Landrau, Nathan Roth, Robert M. Myers
-
Patent number: 5268209Abstract: The invention herein pertains to methods and materials for producing a nicotine maintenance pouch. Laminates comprising a nicotine barrier layer and a nicotine degradation agent barrier layer are disclosed. In a preferred embodiment, the nicotine barrier layer comprises a nitrile rubber modified acrylonitrilemethyl acrylate copolymer. An especially preferred nicotine barrier material comprises, by weight percent, 75% acrylonitrile, and 25% methyl acrylate with 10% butadiene (AN-MA/B). The nicotine degradation agent barrier layer is preferably aluminum foil. In an especially preferred embodiment, the laminate comprises a layer of AN-MA/B adhered to a layer of aluminum foil, which in turn is adhered to a layer of paper stock.Pouches comprising a self-sealed nicotine barrier layer and a nicotine degradation agent barrier layer are disclosed. These pouches are preferably formed from the laminates above.Type: GrantFiled: October 21, 1991Date of Patent: December 7, 1993Assignee: Alza CorporationInventors: James A. Hunt, James L. Osborne, John T. Dunn, Melinda K. Nelson, Nathan Roth
-
Patent number: 5158537Abstract: A dry-state iontophoretic drug delivery device (10, 70, 80) is provided. The device has drug and electrolyte reservoirs (15, 16) which are initially in a non-hydrated condition. A liquid-containing pouch (21, 22) is provided. In certain embodiments the liquid is contained in breakable capsules within the pouch. Water or other liquid can be released from the capsules in the pouch by squeezing or flexing the pouches (21, 22). Alternatively, the liquid can be released from the pouches (21, 22) using pouch piercing pins (36, 37). The liquid released from the pouches (21, 22) hydrates the drug and electrolyte reservoirs (15, 16) and activates the device. In another embodiment, the device (20, 20a) has liquid-containing gel layers (31, 32) which are initially separated from their respective electrode assemblies (8, 9). Liquid-wicking pathways (27, 28) are provided to carry the liquid from the gel layers (31, 32) to the drug and electrolyte layers (15, 16).Type: GrantFiled: October 29, 1990Date of Patent: October 27, 1992Assignee: Alza CorporationInventors: Ronald P. Haak, J. Richard Gyory, Felix Theeuwes, Felix A. Landrau, Nathan Roth, Robert M. Myers
-
Patent number: 5077104Abstract: The invention herein pertains to methods and materials for producing a nicotine maintenance pouch. Laminates comprising a nicotine barrier layer and a nicotine degradation agent barrier layer are disclosed. In a preferred embodiment, the nicotine barrier layer comprises a nitrile rubber modified acrylonitrile-methyl acrylate copolymer. An especially preferred nicotine barrier material comprises, by weight percent, 75% acrylonitrile, and 25% methyl acrylate with 10% butadiene (AN-MA/B). The nicotine degradation agent barrier layer is preferably aluminum foil. In an especially preferred embodiment, the laminate comprises a layer of AN-MA/B adhered to a layer of aluminum foil, which in turn is adhered to a layer of paper stock.Pouches comprising a self-sealed nicotine barrier layer and a nicotine degradation agent barrier layer are disclosed. These pouches are preferably formed from the laminates above.Type: GrantFiled: December 21, 1989Date of Patent: December 31, 1991Assignee: Alza CorporationInventors: James A. Hunt, James L. Osborne, John T. Dunn, Melinda K. Nelson, Nathan Roth