Patents by Inventor Nathan Stasko

Nathan Stasko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9669041
    Abstract: The present invention relates to bath compositions that may release nitric oxide when combined with an aqueous solution, thereby producing a nitric oxide releasing soak and/or bath. The present invention also relates to methods of using nitric oxide releasing bath compositions.
    Type: Grant
    Filed: October 26, 2012
    Date of Patent: June 6, 2017
    Assignee: Novan, Inc.
    Inventors: Nathan Stasko, Ryan Doxey
  • Publication number: 20170056437
    Abstract: Provided according to some embodiments of the invention are topical gels that may release nitric oxide. Also provided are methods of using such topical gels in the treatment of wounds and other skin ailments.
    Type: Application
    Filed: November 16, 2016
    Publication date: March 2, 2017
    Inventors: Nathan Stasko, Susanne Baurman, Pranav R. Joshi
  • Publication number: 20170028214
    Abstract: Systems and methods for phototherapeutic modulation of nitric oxide in mammalian tissue include use of a first wavelength and first radiant flux of light to stimulate enzymatic generation of nitric oxide, and use of a second wavelength and second radiant flux of light to stimulate release of nitric oxide from endogenous stores of nitric oxide. Pulsed light and/or partially non-overlapping light impingement windows may be used. Non-coherent light impinged on tissue may include a peak wavelength in a range of from 410 nm to 440 nm in the absence of light emissions having a peak wavelength of from 600 nm to 900 nm.
    Type: Application
    Filed: July 28, 2016
    Publication date: February 2, 2017
    Inventors: Nathan Stasko, Nicholas William Medendorp, JR., Gerald H. Negley, Katelyn P. Reighard
  • Publication number: 20170028215
    Abstract: Systems and methods for phototherapeutic modulation of nitric oxide in mammalian tissue include use of a first wavelength and first radiant flux of light to stimulate enzymatic generation of nitric oxide, and use of a second wavelength and second radiant flux of light to stimulate release of nitric oxide from endogenous stores of nitric oxide. Pulsed light and/or partially non-overlapping light impingement windows may be used. Non-coherent light impinged on tissue may include a peak wavelength in a range of from 410 nm to 440 nm in the absence of light emissions having a peak wavelength of from 600 nm to 900 nm.
    Type: Application
    Filed: July 28, 2016
    Publication date: February 2, 2017
    Inventors: Nicholas William Medendorp, JR., Katelyn P. Reighard, Gerald H. Negley, Nathan Stasko
  • Patent number: 9526738
    Abstract: Provided according to some embodiments of the invention are topical gels that may release nitric oxide. Also provided are methods of using such topical gels in the treatment of wounds and other skin ailments. The topical gels comprise diazeniutndiolate-functionalized polysiloxane macromolecules.
    Type: Grant
    Filed: August 20, 2010
    Date of Patent: December 27, 2016
    Assignee: Novan, Inc.
    Inventors: Nathan Stasko, Susanne Bauman, Pranav R. Joshi
  • Patent number: 9403851
    Abstract: The presently disclosed subject matter relates to nitric oxide-releasing particles for delivering nitric oxide, and their use in biomedical and pharmaceutical applications.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: August 2, 2016
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Mark H. Schoenfisch, Jae Ho Shin, Nathan Stasko
  • Patent number: 9403852
    Abstract: The presently disclosed subject matter relates to nitric oxide-releasing particles for delivering nitric oxide, and their use in biomedical and pharmaceutical applications.
    Type: Grant
    Filed: February 2, 2015
    Date of Patent: August 2, 2016
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Mark H. Schoenfisch, Jae Ho Shin, Nathan Stasko
  • Publication number: 20160083339
    Abstract: Provided here are nitric oxide-releasing compounds that include at least two different NO donor functional groups of the same class. In some embodiments, such nitric oxide-releasing compounds are macromolecules such as dendrimer and co-condensed silica. Pharmaceutical compositions, wound dressings, kits and methods of treatments are also provided herein.
    Type: Application
    Filed: December 7, 2015
    Publication date: March 24, 2016
    Inventors: Mark Schoenfisch, Yuan Lu, Nathan Stasko, Jian Bao
  • Patent number: 9289442
    Abstract: Provided herein are anhydrous compositions that include at least one viscosity increasing agent, at least one organic solvent and at least one humectant. Such compositions may also include at least one active pharmaceutical ingredient (API) and/or at least one water repellant. Related compositions, methods and kits are also provided.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: March 22, 2016
    Assignee: Novan, Inc.
    Inventors: Ryan Doxey, Nathan Stasko
  • Publication number: 20160060279
    Abstract: The presently disclosed subject matter relates to nitric oxide-releasing particles for delivering nitric oxide, and their use in biomedical and pharmaceutical applications.
    Type: Application
    Filed: December 17, 2014
    Publication date: March 3, 2016
    Inventors: Mark H. Schoenfisch, Jae Ho Shin, Nathan Stasko
  • Patent number: 9267006
    Abstract: Provided according to some embodiments of the invention are methods of making co-condensed macromolecules that include forming a reaction mixture by combining at least one reactant and at least one reagent at a first temperature at which the at least one reactant is substantially unreactive in the presence of the at least one reagent; raising the temperature of the reaction mixture to a second temperature at which the at least one reactant is reactive in the presence of the at least one reagent, wherein the reaction of the at least one reactant in the presence of the at least one reagent produces co-condensed macromolecules such as co-condensed silica macromolecules.
    Type: Grant
    Filed: January 8, 2015
    Date of Patent: February 23, 2016
    Assignee: Novan, Inc.
    Inventors: Jian Bao, Nathan Stasko, Eleftherios Kougoulos
  • Publication number: 20160038390
    Abstract: Provided herein are anhydrous compositions that include at least one viscosity increasing agent, at least one organic solvent and at least one humectant. Such compositions may also include at least one active pharmaceutical ingredient (API) and/or at least one water repellant. Related compositions, methods and kits are also provided.
    Type: Application
    Filed: October 20, 2015
    Publication date: February 11, 2016
    Inventors: Ryan Doxey, Nathan Stasko
  • Patent number: 9238038
    Abstract: Provided here are nitric oxide-releasing compounds that include at least two different NO donor functional groups of the same class. In some embodiments, such nitric oxide-releasing compounds are macromolecules such as dendrimer and co-condensed silica. Pharmaceutical compositions, wound dressings, kits and methods of treatments are also provided herein.
    Type: Grant
    Filed: February 19, 2014
    Date of Patent: January 19, 2016
    Assignees: The University of North Carolina at Chapel Hill, Novan, Inc.
    Inventors: Mark Schoenfisch, Yuan Lu, Nathan Stasko, Jian Bao
  • Publication number: 20160008275
    Abstract: The present invention relates generally to compositions and methods of using the same. A first aspect of the present invention comprises a composition comprising a first viscosity increasing agent; at least one polyhydric alcohol; at least one buffering agent; at least one preservative; a second viscosity increasing agent; at least one organic solvent; at least one humectant; at least one active pharmaceutical ingredient; and water, wherein the composition is buffered to a pH of about 3 to about 11.
    Type: Application
    Filed: February 28, 2014
    Publication date: January 14, 2016
    Inventors: Ryan Doxey, Adam Sabouni, Eleftherios Kougoulos, Nathan Stasko
  • Publication number: 20150182543
    Abstract: The presently disclosed subject matter relates to nitric oxide-releasing particles for delivering nitric oxide, and their use in biomedical and pharmaceutical applications.
    Type: Application
    Filed: February 2, 2015
    Publication date: July 2, 2015
    Inventors: Mark H. Schoenfisch, Jae Ho Shin, Nathan Stasko
  • Publication number: 20150141606
    Abstract: Provided according to some embodiments of the invention are methods of making co-condensed macromolecules that include forming a reaction mixture by combining at least one reactant and at least one reagent at a first temperature at which the at least one reactant is substantially unreactive in the presence of the at least one reagent; raising the temperature of the reaction mixture to a second temperature at which the at lest one reactant is reactive in the presence of the at least one reagent, wherein the reaction of the at least one reactant in the presence of the at least one reagent produces co-condensed macromolecules such as co-condensed silica macromolecules.
    Type: Application
    Filed: January 8, 2015
    Publication date: May 21, 2015
    Inventors: Jian Bao, Nathan Stasko, Eleftherios Kougoulos
  • Patent number: 8962029
    Abstract: The presently disclosed subject matter relates to nitric oxide-releasing particles for delivering nitric oxide, and their use in biomedical and pharmaceutical applications.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: February 24, 2015
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Mark H. Schoenfisch, Jae Ho Shin, Nathan Stasko
  • Patent number: 8956658
    Abstract: The presently disclosed subject matter relates to nitric oxide-releasing particles for delivering nitric oxide, and their use in biomedical and pharmaceutical applications.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: February 17, 2015
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Mark H. Schoenfisch, Jae Ho Shin, Nathan Stasko
  • Patent number: 8937143
    Abstract: Provided according to some embodiments of the invention are methods of making co-condensed macromolecules that include forming a reaction mixture by combining at leak one reactant and at least one reagent at a first temperature at which the at least one reactant is substantially unreactive in the presence of the at least one reagent; raising the temperature of the reaction mixture to a second temperature at which the at least one reactant is reactive in the presence of the at least one reagent, wherein the reaction of the at least one reactant in the presence of the at least one reagent produces co-condensed macromolecules such as co-condensed silica macromolecules.
    Type: Grant
    Filed: July 19, 2013
    Date of Patent: January 20, 2015
    Assignee: Novan, Inc.
    Inventors: Jian Bao, Nathan Stasko, Eleftherios Kougoulos
  • Publication number: 20140255318
    Abstract: The present invention relates to bath compositions that may release nitric oxide when combined with an aqueous solution, thereby producing a nitric oxide releasing soak and/or bath. The present invention also relates to methods of using nitric oxide releasing bath compositions.
    Type: Application
    Filed: October 26, 2012
    Publication date: September 11, 2014
    Inventors: Nathan Stasko, Ryan Doxey