Patents by Inventor Nathaniel Fernhoff
Nathaniel Fernhoff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240075471Abstract: This disclosure provides methods and apparatuses for sorting target particles. In various embodiments, the disclosure provides a cassette for sorting target particles, methods for sorting target particles, methods of loading a microchannel for maintaining sample material viability, methods of quantifying sample material, and an optical apparatus for laser scanning and particle sorting.Type: ApplicationFiled: August 4, 2023Publication date: March 7, 2024Applicant: Orca Biosystems, Inc.Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Lagnajeet Pradhan
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Publication number: 20230372393Abstract: Various embodiments of the invention provide therapeutic compositions and associated methods for improved hematopoietic stem cell transplantations, including methods to enhance protection from graft versus host disease while maintaining effective immune responses such as graft versus tumor immune responses. Embodiments of the invention are particularly useful for treatment of hematologic cancers (e.g., leukemia, lymphoma, GVHD and other diseases).Type: ApplicationFiled: May 2, 2023Publication date: November 23, 2023Inventors: Everett Hurteau MEYER, Robert S. NEGRIN, Nathaniel FERNHOFF, Scott MCCLELLAN, Scott KILLIAN
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Patent number: 11759779Abstract: This disclosure provides methods and apparatuses for sorting target particles. In various embodiments, the disclosure provides a cassette for sorting target particles, methods for sorting target particles, methods of loading a microchannel for maintaining sample material viability, methods of quantifying sample material, and an optical apparatus for laser scanning and particle sorting.Type: GrantFiled: September 12, 2022Date of Patent: September 19, 2023Assignee: Orca Biosystems, Inc.Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Lagnajeet Pradhan
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Publication number: 20230173486Abstract: This disclosure provides methods and apparatuses for sorting target particles. In various embodiments, the disclosure provides a cassette for sorting target particles, methods for sorting target particles, methods of loading a microchannel for maintaining sample material viability, methods of quantifying sample material, and an optical apparatus for laser scanning and particle sorting.Type: ApplicationFiled: September 12, 2022Publication date: June 8, 2023Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Lagnajeet Pradhan
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Patent number: 11471885Abstract: This disclosure provides methods and apparatuses for sorting target particles. In various embodiments, the disclosure provides a cassette for sorting target particles, methods for sorting target particles, methods of loading a microchannel for maintaining sample material viability, methods of quantifying sample material, and an optical apparatus for laser scanning and particle sorting.Type: GrantFiled: June 16, 2020Date of Patent: October 18, 2022Assignee: Orca Biosystems, Inc.Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Lagnajeet Pradhan
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Publication number: 20210339246Abstract: Described are platforms, systems, media, and methods for maintaining a database of items associated with one or more skill requirements and a visit duration; maintaining a database of experts associated with one or more skill proficiencies, a location, and a schedule; receiving a request from a consumer for delivery by an expert of one or more items in the database to a consumer address; identifying experts in the database having skill proficiencies matching the skill requirements of the one or more items and available in a timeslot for the visit duration of the one or more items; presenting timeslots for which one or more experts are identified to the consumer and allowing the consumer to select a timeslot; and selecting an expert from among the identified experts in the selected timeslot based on shortest travel time; provided that utilization of the selected expert exceeds a predetermined utilization threshold.Type: ApplicationFiled: February 24, 2021Publication date: November 4, 2021Inventors: Qiong PAN, Ivan K. DIMOV, Nathaniel FERNHOFF, Lagnajeet PRADHAN, Colm HUNT, Aren Argisht NAZARIAN, Catherine Chih-Tzu YIN
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Publication number: 20210244763Abstract: The present disclosure provides distinct therapeutic populations of cells that form a pharmaceutical composition useful in hematopoietic stem/progenitor cell transplant. For example, the present disclosure provides a therapeutic population of cells, comprising an enriched population of hematopoietic stem/progenitor cells, memory T cells, regulatory T cells, and wherein the population of cells is depleted of naïve conventional ??-T cells. The present disclosure further provides methods of treatment using the therapeutic population of cells. In other embodiments, the present disclosure provides methods of producing a therapeutic population of cells.Type: ApplicationFiled: November 6, 2020Publication date: August 12, 2021Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Kevin Sheehan
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Patent number: 10934355Abstract: Aspects of the present disclosure include methods of treating a subject to reduce adhesion formation, the method comprising administering to a subject in need of thereof an agent that that targets adhesion-formation by injured mesothelial cells. The agent can act at a variety of checkpoints in the development of adhesions by injured mesothelial cells, including: targeting the injured mesothelial cells for destruction, recruiting inflammatory macrophages to the site of adhesion, preventing neutrophil recruitment to the site of adhesion, and/or inhibiting the expression or activity of a gene product whose expression is induced in the injured mesothelial cells. Compositions and kits for performing the methods are also provided.Type: GrantFiled: May 1, 2017Date of Patent: March 2, 2021Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Jonathan Tsai, Nathaniel Fernhoff, Rahul Sinha, Yuval Rinkevich, Irving L. Weissman
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Publication number: 20210016277Abstract: This disclosure provides methods and apparatuses for sorting target particles. In various embodiments, the disclosure provides a cassette for sorting target particles, methods for sorting target particles, methods of loading a microchannel for maintaining sample material viability, methods of quantifying sample material, and an optical apparatus for laser scanning and particle sorting.Type: ApplicationFiled: June 16, 2020Publication date: January 21, 2021Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Lagnajeet Pradhan
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Patent number: 10857183Abstract: The present disclosure provides distinct therapeutic populations of cells that form a pharmaceutical composition useful in hematopoietic stem/progenitor cell transplant. For example, the present disclosure provides a therapeutic population of cells, comprising an enriched population of hematopoietic stem/progenitor cells, memory T cells, regulatory T cells, and wherein the population of cells is depleted of naïve conventional ??-T cells. The present disclosure further provides methods of treatment using the therapeutic population of cells. In other embodiments, the present disclosure provides methods of producing a therapeutic population of cells.Type: GrantFiled: April 18, 2019Date of Patent: December 8, 2020Assignee: ORCA BIOSYSTEMS, INC.Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Kevin Sheehan
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Patent number: 10722885Abstract: This disclosure provides methods and apparatuses for sorting target particles. In various embodiments, the disclosure provides a cassette for sorting target particles, methods for sorting target particles, methods of loading a microchannel for maintaining sample material viability, methods of quantifying sample material, and an optical apparatus for laser scanning and particle sorting.Type: GrantFiled: May 29, 2019Date of Patent: July 28, 2020Assignee: ORCA BIOSYSTEMS, INC.Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Lagnajeet Pradhan
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Publication number: 20200061612Abstract: This disclosure provides methods and apparatuses for sorting target particles. In various embodiments, the disclosure provides a cassette for sorting target particles, methods for sorting target particles, methods of loading a microchannel for maintaining sample material viability, methods of quantifying sample material, and an optical apparatus for laser scanning and particle sorting.Type: ApplicationFiled: May 29, 2019Publication date: February 27, 2020Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Lagnajeet Pradhan
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Publication number: 20190298773Abstract: The present disclosure provides distinct therapeutic populations of cells that form a pharmaceutical composition useful in hematopoietic stem/progenitor cell transplant. For example, the present disclosure provides a therapeutic population of cells, comprising an enriched population of hematopoietic stem/progenitor cells, memory T cells, regulatory T cells, and wherein the population of cells is depleted of naïve conventional ??-T cells. The present disclosure further provides methods of treatment using the therapeutic population of cells. In other embodiments, the present disclosure provides methods of producing a therapeutic population of cells.Type: ApplicationFiled: April 18, 2019Publication date: October 3, 2019Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Kevin Sheehan
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Patent number: 10350595Abstract: This disclosure provides methods and apparatuses for sorting target particles. In various embodiments, the disclosure provides a cassette for sorting target particles, methods for sorting target particles, methods of loading a microchannel for maintaining sample material viability, methods of quantifying sample material, and an optical apparatus for laser scanning and particle sorting.Type: GrantFiled: July 24, 2018Date of Patent: July 16, 2019Assignee: Orca Biosystems, Inc.Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Lagnajeet Pradhan
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Publication number: 20190212332Abstract: The disclosure provides methods and apparatus for high speed and sterile sorting of heterogeneous populations of cells to isolate homogenous populations. In embodiments, the disclosure provides a micropore array and collection tray situated within a sterile, closed cartridge.Type: ApplicationFiled: September 19, 2017Publication date: July 11, 2019Inventors: Ivan DIMOV, Nathaniel FERNHOFF, Irving WEISSMAN, Charles Kwok Fai CHAN, Everett MEYER, Peter Lincoln WANG, Bruce RICHARDSON
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Patent number: 10300090Abstract: The present disclosure provides distinct therapeutic populations of cells that form a pharmaceutical composition useful in hematopoietic stem/progenitor cell transplant. For example, the present disclosure provides a therapeutic population of cells, comprising an enriched population of hematopoietic stem/progenitor cells, memory T cells, regulatory T cells, and wherein the population of cells is depleted of naïve conventional ??-T cells. The present disclosure further provides methods of treatment using the therapeutic population of cells. In other embodiments, the present disclosure provides methods of producing a therapeutic population of cells.Type: GrantFiled: March 15, 2018Date of Patent: May 28, 2019Assignee: Orca Biosystems, Inc.Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Kevin Sheehan
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Publication number: 20190048077Abstract: Aspects of the present disclosure include methods of treating a subject to reduce adhesion formation, the method comprising administering to a subject in need of thereof an agent that that targets adhesion-formation by injured mesothelial cells. The agent can act at a variety of checkpoints in the development of adhesions by injured mesothelial cells, including: targeting the injured mesothelial cells for destruction, recruiting inflammatory macrophages to the site of adhesion, preventing neutrophil recruitment to the site of adhesion, and/or inhibiting the expression or activity of a gene product whose expression is induced in the injured mesothelial cells. Compositions and kits for performing the methods are also provided.Type: ApplicationFiled: May 1, 2017Publication date: February 14, 2019Inventors: Jonathan Tsai, Nathaniel Fernhoff, Rahul Sinha, Yuval Rinkevich, Irving L. Weissman
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Publication number: 20180353960Abstract: This disclosure provides methods and apparatuses for sorting target particles. In various embodiments, the disclosure provides a cassette for sorting target particles, methods for sorting target particles, methods of loading a microchannel for maintaining sample material viability, methods of quantifying sample material, and an optical apparatus for laser scanning and particle sorting.Type: ApplicationFiled: July 24, 2018Publication date: December 13, 2018Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Lagnajeet Pradhan
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Publication number: 20180264039Abstract: The present disclosure provides distinct therapeutic populations of cells that form a pharmaceutical composition useful in hematopoietic stem/progenitor cell transplant. For example, the present disclosure provides a therapeutic population of cells, comprising an enriched population of hematopoietic stem/progenitor cells, memory T cells, regulatory T cells, and wherein the population of cells is depleted of naïve conventional ??-T cells. The present disclosure further provides methods of treatment using the therapeutic population of cells. In other embodiments, the present disclosure provides methods of producing a therapeutic population of cells.Type: ApplicationFiled: March 15, 2018Publication date: September 20, 2018Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Kevin Sheehan