Abstract: The invention generally relates to systems and methods for determining a probability of a female subject having a cardiac event.

Abstract: The invention relates to systems and methods for three dimensional imaging of tissue. The invention provides systems and methods to provide a representation of tissue from three-dimensional data that includes intravascular imaging data as well as data representing a shape of the intravascular imaging probe. Device of the invention combine a shape-sensing mechanism with an intravascular intervention catheter.

Abstract: The invention generally relates to apparatuses and methods for imaging inside a vessel. In certain aspects, the invention provides an apparatus that includes an imaging device configured to image an inside of a vessel, and a sensing device configured to detect a conformational shape of the apparatus.

Abstract: The invention generally relates to an optical coherence tomography system that is reconfigurable between two different imaging modes and methods of use thereof.

Abstract: The present invention generally relates to optical circuits for mitigating power loss in medical imaging systems and methods for using such circuits. Circuits of the invention can involve a first optical path, a second optical path, and a means for recombining an optical signal transmitted through the first and second optical paths by sequentially gating the first and second optical paths to a single output.

Abstract: The invention generally relates to a polarization sensitive optical coherence tomography (OCT) system that includes both polarization maintaining and single mode optical fiber and methods of use thereof.

Abstract: A method for artifact management in a rotational imaging system is presented. The method includes the steps of acquiring data employing a helical scanning pattern over N revolutions, where N is greater than 1, and detecting at least one artifact in the acquired data of each revolution. The method further includes segmenting the data acquired over N revolutions into N-1 data frames each bounded by at least one of the at least one artifacts.

Abstract: The invention relates generally systems for correcting distortion in a medical image and methods of use thereof. Methods and systems for displaying a medical image of a lumen of a biological structure, generally comprise obtaining image data of a lumen of a biological structure from an imaging device, correcting the image data for translational distortions, in which correcting is accomplished without reference to another data set, and displaying a corrected image.

Abstract: The invention relates to systems and methods for the operation of three-dimensional imaging systems.

Abstract: A method and a system for Uniform Frequency Sample Clocking to directly sample the OCT signal with a temporally-non-linear sampling clock derived from a k-space wavemeter on the external sample clock input port of a digitizer.

Abstract: This invention relates generally to the detection of objects, such as stents, within intraluminal images using principal component analysis and/or regional covariance descriptors. In certain aspects, a training set of pre-defined intraluminal images known to contain an object is generated. The principal components of the training set can be calculated in order to form an object space. An unknown input intraluminal image can be obtained and projected onto the object space. From the projection, the object can be detected within the input intraluminal image. In another embodiment, a covariance matrix is formed for each pre-defined intraluminal image known to contain an object. An unknown input intraluminal image is obtained and a covariance matrix is computed for the input intraluminal image. The covariances of the input image and each image of the training set are compared in order to detect the presence of the object within the input intraluminal image.

Abstract: A polarization sensitive spectral interferometer apparatus and method for analyzing a sample by optical energy reflected from the sample. The polarization sensitive spectral interferometer apparatus and method determines polarization properties of the sample by optical energy reflected from the sample.

Abstract: The invention relates to systems and methods for three dimensional imaging of tissue. Systems and methods of the invention receive a three dimensional data set and display a series of coaxial longitudinal images (i.e., each rotationally offset from another around an axis) in sequence, creating a video effect as if the view were scrolling around the tissue.

Abstract: The invention generally relates to medical imaging systems that instantly and/or automatically detect borders. Embodiments of the invention provide an imaging system that automatically detects a border at a location within a vessel in response only to navigational input moving the image to that location. In some embodiments, systems and methods of the invention operate such that when a doctor moves an imaging catheter to a new location with in tissue, the system essentially instantly finds, and optionally displays, the border(s), calculates an occlusion, or both.

Abstract: Systems and methods for aiding users in viewing, assessing and analyzing images, especially images of lumens and medical devices contained within the lumens. Systems and methods for interacting with images of lumens and medical devices, for example through a graphical user interface.

Abstract: Provided are forward-imaging optical coherence tomography (OCT) systems and probes.

Abstract: The embodiments disclosed herein is related to a system for optical coherence tomographic imaging of turbid (i.e., scattering) materials utilizing multiple channels of information. The multiple channels of information may be comprised and encompass spatial, angle, spectral and polarization domains. More specifically, the embodiments disclosed herein is related to methods and apparatus for utilizing optical sources, systems or receivers capable of providing (source), processing (system) or recording (receiver) a multiplicity of channels of spectral information for optical coherence tomographic imaging of turbid materials. In these methods and apparatus the multiplicity of channels of spectral information that can be provided by the source, processed by the system, or recorded by the receiver are used to convey simultaneously spatial, spectral or polarimetric information relating to the turbid material being imaged tomographically.

Abstract: The invention provides systems and methods for producing an OCT image from a swept laser source. In certain embodiments, methods of the invention involve producing light from a swept laser source, splitting the light into a first and a second portion, in which the first portion is sent to an OCT interferometer to produce an OCT signal and the second portion is sent to a uniform frequency sample clock, processing the second portion into an external clock signal that is accepted by a digitizer, sending the OCT signal and the clock signal to the digitizer, and generating an OCT image from a combination of the OCT signal and the clock signal.

Abstract: A polarization sensitive spectral interferometer apparatus and method for analyzing a sample by optical energy reflected from the sample. The polarization sensitive spectral interferometer apparatus and method determines polarization properties of the sample by optical energy reflected from the sample.

Abstract: The invention is a rotating tip catheter-imaging probe where electromagnetic energy is delivered to the distal end of a catheter and converted to mechanical energy using a light drive apparatus. The mechanical energy is then used to rotate a mirror that redirects light in fixed pattern on a sample. The rotating element of the light drive apparatus contains vanes, which rotate about an axis and positioned with bearings to minimize friction. A chamber encompasses the rotating element and is set to a vacuum pressure. The rotational speed of the catheter tip can be controlled by varying the optical power delivered to the vanes, the vacuum pressure in the chamber, or by a braking mechanism applied to the rotating element. The vanes may be shaped in a particular geometry to increase forces on the vanes from thermally driven gas flow.