Abstract: Granules that include a protein core are described. The protein core includes a protein matrix which includes a protein mixed together with a starch and optionally sugar such as sucrose. The protein matrix can be layered over a seed particle or the protein core can be homogeneous. The protein can be an enzyme or a therapeutic protein. A barrier layer may surround the protein core, and a coating can be applied to the seed particle, the protein matrix and/or the barrier layer.

Abstract: The present invention relates to compositions comprising high molecular weight polymers, particularly polyethylene oxide polymers, wherein the high molecular weight polymer serves as an anti-misting agent to reduce the potential of aerosol generation from a composition when used in a desired environment. The invention further relates to methods of decreasing enzyme exposure from a personal care or cleaning product comprising a high molecular weight polymer.

Abstract: A granule having high stability and low dust is described. The granule includes a hydrated barrier material having moderate or high water activity. Also described are methods of producing the granules.

Abstract: Enzyme-containing formulations having improved stability and enzymatic activity in liquid medium, comprising one or more protease enzymes produced from any Bacillus bacteria, at least about 5% alkali metal halide salt, and at least about 50% polyol. Also disclosed are methods for making such formulations.

Abstract: There is provided a process for the extraction of water soluble biomaterials such as enzymes or proteins into carbon dioxide utilizing certain carbon dioxide-soluble surfactants. Also provided are certain carbon dioxide-soluble surfactants useful in the extraction of proteins. The surfactants are selected from fluoroether sulfate, fluoroether-polyethylene glycol block copolymer, fluoroether-functional sorbitol, and fluoroether dithiocarbamate chelate.

Abstract: Methods and formulations for enhancing the dissolution of a solid material in an aqueous solution incorporate an effervescent system into the material. Effervescent systems include (i) the combination of one or more enzymes and one or more substrates for said enzymes and (ii) a metal ion catalyst and a substrate for that metal ion catalyst. The combination of either (i) the enzyme and the substrate or (i) metal ion catalyst and substrate is capable of producing a gas when the material is in an aqueous solution. The effervescent system is particularly suited for incorporation into laundry detergents, dishwashing detergents, antacids, vitamins, contact lens cleaners, denture cleaners and other household products. It is believed that the gas produced by the interaction of the enzyme or metal ion catalyst and the appropriate substrate enhances and facilitates dissolution of the material by increasing the surface area of the material that is in contact with the aqueous medium.

Abstract: A granule having high stability and low dust is described. The granule includes a hydrated barrier material having moderate or high water activity. Also described are methods of producing the granules.

Abstract: The present invention provides highly impact-resistant, water-soluble or water dispersible, low-dust granules comprising an active ingredient and methods for obtaining the same.

Abstract: A method is provided for the extraction of water soluble biomaterials such as enzymes or proteins into carbon dioxide utilizing certain carbon dioxide soluble surfactants. The extraction can be performed on an aqueous solution, a fermentation broth or a fluid. The method includes the process steps of forming a carbon dioxide/surfactant mixture which involves dissolving carbon dioxide soluble surfactant(s) in carbon dioxide. The carbon dioxide can be in a liquid or supercritical form and the surfactant includes tail and head groups that interact with the biomaterials. Further, the mixture is added to the aqueous solution, fermentation broth or liquid under conditions to allow for extraction of the biomaterials. The method further includes depressurizing and/or temperature adjusting to remove the water soluble biomaterials. The surfactants include fluroethers, oligomers of propylene-oxide, siloxanes, etc. The biomaterials include proteins or enzymes. The carbon dioxide is suberitical or supercritical.

Abstract: Granules that include a protein core are described. The protein core includes a protein matrix which includes a protein mixed together with a starch. The protein matrix can be layered over a seed particle or the protein core can be homogeneous. The protein can be an enzyme or a therapeutic protein.

Abstract: The present invention provides a particle containing a peroxide-sensitive component (such as an enzyme; e.g., a hydrolase) and an added catalase component. The particle can be included in a detergent composition with peroxygen bleach.

Abstract: A fluidized bed coating apparatus is provided and includes a fluid inlet adapted to be connected to a source of fluidizing fluid. The fluid inlet has an entrance opening having a first diameter and an exit opening downstream of the entrance opening. The exit opening has a second diameter that is larger than the first diameter. The inlet also includes an expanding inlet section, between the entrance opening and the exit opening, that has an average diameter that increases in a direction from said entrance opening to said exit opening. A fluid distribution plate is provided adjacent the exit opening and includes a plurality of through-passages to allow the even and distributed passage of a fluidizing fluid therethrough. A chamber having a chamber inlet and a chamber outlet is provided and the fluid distribution plate is positioned between the exit opening and the chamber inlet.

Abstract: Detergent formulations are prepared by directly agglomerating a fermentation broth extract, containing a detergent-type enzyme and a nonionic detergent-type surfactant, with a suitable detergent base mixture, without need for prior isolation of the enzyme.

Abstract: The present invention provides an improved coating material for use with particles, such as enzyme granules, and the like. In particular, the present invention provides a modified PVA, as well as particles or granules that include such coating. The PVA is modified by substituting hydrophilic moieties for the hydroxyl or alcohol groups of the PVA. Substitution may be achieved with hydrophilic acids, amines, thiols, or combinations thereof.

Abstract: Granules are prepared containing an admixture of protein and salt layered over an inert particle. A preferred amount of salt is about between 63.7 and 84.3% of the total weight of the admixture. Proteins include pharmaceutically important proteins such as hormones, or industrially important proteins such as enzymes including proteases, amylases, lipases and cellulases capable of hydrolyzing substrates such as stains. Inert particles include inorganic salts, sugars, sugar alcohols, small organic molecules such as organic acids or salts, and minerals such as clays or silicates. A binder such as starch or polyethylene oxide may be mixed in with the admixture. A barrier material such as an inorganic salt or organic acid or salt may be in the admixture or coated over the admixture layer. A coating layer of a soluble or water dispersible film-forming polymer may be between the inert particle and admixture layer and/or over the admixture layer.

Abstract: Granules are prepared containing an admixture of protein and starch layered over an inert particle. Proteins include pharmaceutically important proteins such as hormones, or industrially important proteins such as enzymes including proteases, amylases, lipases and cellulases capable of hydrolyzing substrates such as stains. Inert particles include inorganic salts, sugars, sugar alcohols, small organic molecules such as organic acids or salts, and minerals such as clays or silicates. The admixture may also contain sugar such as sucrose. A ratio of corn starch to sugar much greater than 1:1 such as in a range of about 5:1 to about 15:1 is preferred. A coating layer may be between the inert particle and the admixture and/or over the admixture. Methods that may be used in preparing the granules include pan-coating, fluid-bed coating, prilling, disc granulation, spray drying, extrusion, centrifugal extrusion, spheronization, drum granulation and high shear agglomeration.

Abstract: Coatings for pharmaceutical dosage forms, food and confectionery tablets, seeds and granule cores are described. The coating includes a modified starch and a plasticizer optionally in combination with a secondary polymer. Also described is a coating including a modified starch and a secondary polymer optionally in combination with a plasticizer. Also described are coated pharmaceutical dosage forms, food and confectionery tablets, seeds and granule cores. Further described are cleaning, textile and feed compositions including the coated granule cores.

Abstract: A process for recovering a protein such as an enzyme from an aqueous solution using a lignosulfonate having a low degree of sulfonation. Also disclosed are protein/lignosulfonate complexes and use of these in granules.

Abstract: Granules that include a protein core are described. The protein core includes a protein matrix which includes a protein mixed together with a salt. The protein matrix is layered over a seed particle. The protein can be an enzyme or a therapeutic protein such as a hormone. Methods of making the granules are also described.

Abstract: Granules that include a protein core are described. The protein core includes a protein matrix which includes a protein mixed together with a combination of a sugar or sugar alcohol and a structuring agent such as a polysaccharide or a polypeptide. The protein matrix can be layered over a seed particle or the protein granule can be homogeneous. The protein can be an enzyme or a therapeutic protein such as a hormone. Also described are methods for making the granules.