Patents by Inventor Nathaniel W. Silver

Nathaniel W. Silver has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and Formulations and Methods of Production and Use Thereof
    Publication number: 20220347262
    Abstract: Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.
    Type: Application
    Filed: December 2, 2021
    Publication date: November 3, 2022
    Inventors: Alison Williams, Nathaniel W. Silver, Andrew Downey, David V. Erbe, Michael J. Hamill, David Arthur Berry
  • Compositions and Formulations and Methods of Production and Use Thereof
    Publication number: 20200405807
    Abstract: Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.
    Type: Application
    Filed: July 1, 2020
    Publication date: December 31, 2020
    Inventors: Alison Williams, Nathaniel W. Silver, Andrew Downey, David V. Erbe, Michael J. Hamill, David Arthur Berry
  • Charged Nutritive Proteins and Methods
    Publication number: 20200109175
    Abstract: Charged nutritive proteins are provided. In some embodiments the nutritive proteins an aqueous solubility of at least 12.5 g/L at pH 7. In some embodiments the nutritive proteins an aqueous solubility of at least 50 g/L at pH 7. In some embodiments the nutritive proteins an aqueous solubility of at least 100 g/L at pH 7.
    Type: Application
    Filed: September 10, 2019
    Publication date: April 9, 2020
    Inventors: David Arthur Berry, Brett Adam Boghigian, Nathaniel W. Silver, Geoffrey von Maltzahn, Michael Hamill, Rajeev Chillakuru, John F. Kramarczyk
  • Charged nutritive proteins and methods
    Patent number: 10450350
    Abstract: Charged nutritive proteins are provided. In some embodiments the nutritive proteins an aqueous solubility of at least 12.5 g/L at pH 7. In some embodiments the nutritive proteins an aqueous solubility of at least 50 g/L at pH 7. In some embodiments the nutritive proteins an aqueous solubility of at least 100 g/L at pH 7.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: October 22, 2019
    Assignee: Axcella Health Inc.
    Inventors: David Arthur Berry, Brett Adam Boghigian, Nathaniel W. Silver, Geoffrey von Maltzahn, Michael Hamill, Rajeev Chillakuru, John F. Kramarczyk
  • Compositions and Formulations and Methods of Production and Use Thereof
    Publication number: 20180125926
    Abstract: Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.
    Type: Application
    Filed: October 4, 2017
    Publication date: May 10, 2018
    Inventors: Alison Williams, Nathaniel W. Silver, Andrew Downey, David V. Erbe, Michael J. Hamill, David Arthur Berry
  • Nutritive fragments, proteins and methods
    Patent number: 9944681
    Abstract: Nutritive proteins are provided. In some embodiments the nutritive proteins comprise a first polypeptide sequence comprising a fragment of a naturally-occurring nutritive protein. In some embodiments the fragment comprises at least one of a) an enhanced ratio of branch chain amino acid residues to total amino acid residues present in the nutritive protein; b) an enhanced ratio of leucine residues to total amino acid residues present in the nutritive protein; and c) an enhanced ratio of essential amino acid residues to total amino acid residues present in the nutritive protein.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: April 17, 2018
    Assignee: Axcella Health Inc.
    Inventors: David Arthur Berry, Brett Adam Boghigian, Nathaniel W. Silver, Geoffrey von Maltzahn, Rajeev Chillakuru, Michael Hamill, John F. Kramarczyk
  • Compositions and formulations for treatment of gastrointestinal tract malabsorption diseases and inflammatory conditions and methods of production and use thereof
    Patent number: 9878004
    Abstract: Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.
    Type: Grant
    Filed: September 25, 2014
    Date of Patent: January 30, 2018
    Assignee: Axcella Health Inc.
    Inventors: Alison Williams, Michael J. Hamill, Nathaniel W. Silver, Ying-Ja Chen, David Arthur Berry, David V. Erbe, Chung-Wei Lee, Luke Hamm
  • Charged Nutritive Fragments, Proteins and Methods
    Publication number: 20170327548
    Abstract: Charged nutritive proteins provided. In some embodiments the nutritive proteins an aqueous solubility of at least 12.5 g/L at pH 7. In some embodiments the nutritive proteins an aqueous solubility of at least 50 g/L at pH 7. In some embodiments the nutritive proteins an aqueous solubility of at least 100 g/L at pH 7.
    Type: Application
    Filed: April 19, 2017
    Publication date: November 16, 2017
    Inventors: Michael J. Hamill, Nathaniel W. Silver, Rajeev Chillakuru, John F. Kramarczyk, David Arthur Berry, Brett Adam Boghigian, Geoffrey von Maltzahn
  • Nutritive Proteins and Methods
    Publication number: 20170298102
    Abstract: Nutritive proteins are provided. In some embodiments the nutritive proteins comprise at least one of a level of a) a ratio of branch chain amino acid residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of branch chain amino acid residues to total amino acid residues present in whey protein; b) a ratio of leucine residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of leucine residues to total amino acid residues present in whey protein; and c) a ratio of essential amino acid residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of essential amino acid residues to total amino acid residues present in whey protein.
    Type: Application
    Filed: February 10, 2017
    Publication date: October 19, 2017
    Inventors: Geoffrey von Maltzahn, Michael J. Hamill, Rajeev Chillakuru, John F. Kramarczyk, David Arthur Berry, Brett Adam Boghigian, Nathaniel W. Silver
  • Nutritive Fragments, Proteins and Methods
    Publication number: 20170253639
    Abstract: Nutritive proteins are provided. In some embodiments the nutritive proteins comprise a first polypeptide sequence comprising a fragment of a naturally-occurring nutritive protein. In some embodiments the fragment comprises at least one of a) an enhanced ratio of branch chain amino acid residues to total amino acid residues present in the nutritive protein; b) an enhanced ratio of leucine residues to total amino acid residues present in the nutritive protein; and c) an enhanced ratio of essential amino acid residues to total amino acid residues present in the nutritive protein.
    Type: Application
    Filed: February 10, 2017
    Publication date: September 7, 2017
    Inventors: David Arthur Berry, Brett Adam Boghigian, Nathaniel W. Silver, Geoffrey von Maltzahn, Rajeev Chillakuru, Michael Hamill, John F. Kramarczyk
  • Charged Nutritive Proteins and Methods
    Publication number: 20170246244
    Abstract: Charged nutritive proteins are provided. In some embodiments the nutritive proteins an aqueous solubility of at least 12.5 g/L at pH 7. In some embodiments the nutritive proteins an aqueous solubility of at least 50 g/L at pH 7. In some embodiments the nutritive proteins an aqueous solubility of at least 100 g/L at pH 7.
    Type: Application
    Filed: February 10, 2017
    Publication date: August 31, 2017
    Inventors: David Arthur Berry, Brett Adam Boghigian, Nathaniel W. Silver, Geoffrey von Maltzahn, Michael Hamill, Rajeev Chillakuru, John F. Kramarczyk
  • Nutritive fragments, proteins and methods
    Patent number: 9700071
    Abstract: Nutritive proteins are provided. In some embodiments the nutritive proteins comprise a protein digestibility corrected amino acid score (PDCAAS) that exceeds a benchmark protein. Also provided are nucleic acids encoding the proteins, recombinant microorganisms that make the proteins, methods of making the proteins using recombinant microorganisms, compositions that comprise the proteins, and methods of using the proteins, among other things.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: July 11, 2017
    Assignee: Axcella Health Inc.
    Inventors: Nathaniel W. Silver, Geoffrey von Maltzahn, Michael J. Hamill, David Arthur Berry
  • Charged nutritive proteins and methods
    Patent number: 9611298
    Abstract: Charged nutritive proteins are provided. In some embodiments the nutritive proteins an aqueous solubility of at least 12.5 g/L at pH 7. In some embodiments the nutritive proteins an aqueous solubility of at least 50 g/L at pH 7. In some embodiments the nutritive proteins an aqueous solubility of at least 100 g/L at pH 7.
    Type: Grant
    Filed: July 22, 2014
    Date of Patent: April 4, 2017
    Assignee: Axcella Health Inc.
    Inventors: David Arthur Berry, Brett Adam Boghigian, Nathaniel W. Silver, Geoffrey von Maltzahn, Michael Hamill, Rajeev Chillakuru, John F. Kramarczyk
  • Nutritive proteins and methods
    Patent number: 9605040
    Abstract: Nutritive proteins are provided. In some embodiments the nutritive proteins comprise at least one of a level of a) a ratio of branch chain amino acid residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of branch chain amino acid residues to total amino acid residues present in whey protein; b) a ratio of leucine residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of leucine residues to total amino acid residues present in whey protein; and c) a ratio of essential amino acid residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of essential amino acid residues to total amino acid residues present in whey protein.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: March 28, 2017
    Assignee: Axcella Health Inc.
    Inventors: Geoffrey von Maltzahn, Michael J. Hamill, Rajeev Chillakuru, John F. Kramarczyk, David Arthur Berry, Brett Adam Boghigian, Nathaniel W. Silver
  • Nutritive fragments, proteins and methods
    Patent number: 9598474
    Abstract: Nutritive proteins are provided. In some embodiments the nutritive proteins comprise a first polypeptide sequence comprising a fragment of a naturally-occurring nutritive protein. In some embodiments the fragment comprises at least one of a) an enhanced ratio of branch chain amino acid residues to total amino acid residues present in the nutritive protein; b) an enhanced ratio of leucine residues to total amino acid residues present in the nutritive protein; and c) an enhanced ratio of essential amino acid residues to total amino acid residues present in the nutritive protein.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: March 21, 2017
    Assignee: Axcella Health, Inc.
    Inventors: David Arthur Berry, Brett Adam Boghigian, Nathaniel W. Silver, Geoffrey von Maltzahn, Rajeev Chillakuru, Michael Hamill, John F. Kramarczyk
  • Compositions and Formulations for Increasing Renal Function and Treatment and Prevention of Renal Diseases, and Methods of Production and Use Thereof
    Publication number: 20160354436
    Abstract: Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.
    Type: Application
    Filed: September 25, 2014
    Publication date: December 8, 2016
    Inventors: Alison WILLIAMS, Nathaniel W. SILVER, Andrew DOWNEY, David V. ERBE, Michael J. HAMILL, David Arthur BERRY
  • Compositions and Formulations for Treatment of Gastrointestinal Tract Malabsorption Diseases and Inflammatory Conditions and Methods of Production and Use Thereof
    Publication number: 20160317614
    Abstract: Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.
    Type: Application
    Filed: September 25, 2014
    Publication date: November 3, 2016
    Inventors: Alison Williams, Michael J. Hamill, Nathaniel W. Silver, Ying-Ja Chen, David Arthur Berry, David V. Erbe, Chung-Wei Lee, Luke Hamm
  • Compositions and Formulations for Prevention and Reduction of Tumorigenesis, Cancer Cell Proliferation and Invasion, and Methods of Production and Use Thereof in Cancer Treatment
    Publication number: 20160228506
    Abstract: Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.
    Type: Application
    Filed: September 24, 2014
    Publication date: August 11, 2016
    Inventors: Noubar B. Afeyan, Chung-Wei Lee, Nathaniel W. Silver, David Arthur Berry, Michael J. Hamill, David V. Erbe
  • Compositions and Formulations for Prevention and Treatment of Diabetes and Obesity, and Methods of Production and Use Thereof in Glucose and Caloric Control
    Publication number: 20160228503
    Abstract: Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.
    Type: Application
    Filed: September 25, 2014
    Publication date: August 11, 2016
    Inventors: Nathaniel W. Silver, Luke Hamm, Carine Robichon-Iyer, Alison Williams, Michael J. Hamill, David Arthur Berry, Shaila Rahman, Kathryn Heard
  • Compositions and Formulations for Maintaining and Increasing Muscle Mass, Strength, and Performance and Methods of Production and Use Thereof
    Publication number: 20160219910
    Abstract: Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.
    Type: Application
    Filed: September 25, 2014
    Publication date: August 4, 2016
    Inventors: Nathaniel W. Silver, Ying-Ja Chen, David Arthur Berry, Michael J. Hamill, Subhayu Basu, Luke Hamm, Alison Williams, David V. Erbe, Geoffrey von Maltzahn