Abstract: This invention pertains to a method and apparatus for facilitating guided growth of axons and dendrites in cell culture, for example for studies of axonal pathfinding, target cell selection, synapse formation, synaptic physiology, neuronal plasticity, drugs screening and gene perturbations. In a preferred embodiment, the invention includes a semiconducting substrate surface containing an array of capacitors that directly stimulate and read from neurons cultured on the surface. The chip may also have patterns of growth permissive substances, including Schwann cells, and/or trophic molecules that enable rapid and directed growth of axons/dendrites from cultured neurons.

Abstract: This document provides assay systems related to detecting electrical activity and assessing agents for the ability to influence electrical activity. For example, methods and materials for identifying agents capable of treating seizure like behavior are provided herein.

Abstract: This document pertains generally to the field of nerve regeneration and more particularly to functional recovery after nerve injury or transection. For example, this document provides a silicon chip device coupled with field effect (or other types of) transistors, growth permissive chemical substrates, and trophic molecules that together can enable the rapid and successful regeneration of injured nerves. Such devices can be used to stimulate continually the transected target tissue to create an environment that is highly conducive to growth and reinnervation.