Patents by Inventor Nazzareno DIMASI

Nazzareno DIMASI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BRANCHED MOIETY FOR USE IN CONJUGATES
    Publication number: 20240123081
    Abstract: A tri-functional linker moiety: formula (I), where X and Y are linking chains, and its use for preparing dual-mechanistic drug conjugates, preferably in a site-specific manner.
    Type: Application
    Filed: October 25, 2019
    Publication date: April 18, 2024
    Inventors: Nazzareno DIMASI, Amit KUMAR
  • IMMUNOCYTOKINES FOR TREATMENT OF AUTOIMMUNE AND INFLAMMATORY CONDITIONS
    Publication number: 20230279092
    Abstract: Abstract: The present disclosure is directed to fusion proteins comprising a Tumor Necrosis Factor ? (TNF?) binding protein and an interleukin-10 (IL-10) molecule, methods of making the fusion proteins, and methods of treating or preventing autoimmune and inflammatory conditions using the fusion proteins.
    Type: Application
    Filed: July 20, 2021
    Publication date: September 7, 2023
    Inventors: Partha S. CHOWDHURY, Yong-Jun LIU, Shino HANABUCHI, Nazzareno DIMASI
  • Pyrrolobenzodiazepine conjugates
    Patent number: 11649250
    Abstract: A conjugate of formula (I) wherein Ab is a modified antibody having at least one free conjugation site on each heavy chain.
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: May 16, 2023
    Assignee: MEDIMMUNE LIMITED
    Inventors: Nazzareno Dimasi, Philip Wilson Howard, Luke Masterson, Arnaud Charles Tiberghien, Balakumar Vijayakrishnan, Jason White
  • Nucleic acids encoding anti-VEGF-A antibodies and uses thereof
    Patent number: 11634483
    Abstract: The present invention relates to antibodies having activity against a vascular endothelial growth factor (VEGF), and methods of making and using such antibodies.
    Type: Grant
    Filed: January 19, 2021
    Date of Patent: April 25, 2023
    Assignee: MEDIMMUNE LIMITED
    Inventors: Ching Ching Leow, Nazzareno Dimasi, Karen Coffman, Ping Tsui, Changshou Gao, Mario A. Cepeda, Adrian Schwartz Mittelman
  • Nucleic acids encoding bispecific anti-VEGF and anti-ANG2 antibodies and uses thereof
    Patent number: 11566068
    Abstract: The present invention relates to bispecific antibodies having activity against a vascular endothelial growth factor (VEGF) and an angiopoietin (ANG), and methods of making and using such bispecific antibodies.
    Type: Grant
    Filed: October 14, 2020
    Date of Patent: January 31, 2023
    Assignee: MEDIMMUNE LIMITED
    Inventors: Ching Ching Leow, Nazzareno Dimasi, Karen Coffman, Ryan Fleming, Ping Tsui, Changshou Gao, Mario A. Cepeda, Adrian Schwartz Mittelman
  • Methods for preparing antibodies with a defined glycosylation pattern
    Patent number: 11414477
    Abstract: The present disclosure relates to a process for preparing antibodies with a defined glycosylation pattern, in particular antibodies with a glycan terminating in an N-acetylglucosamine. The antibodies of the disclosure are suitable for use in a process to conjugate a payload thereto. The disclosure also extends to molecules obtained and obtainable from the process disclosed herein, novel molecules and intermediates, compositions comprising said molecules and uses of the molecules and compositions, particularly in treatment, for example in the treatment of cancer.
    Type: Grant
    Filed: January 26, 2017
    Date of Patent: August 16, 2022
    Assignee: MedImmune, LLC
    Inventors: Changshou Gao, Pamela Thompson, Dorin Toader, Nazzareno Dimasi
  • COMBINATION THERAPIES USING ANTI-PSEUDOMONAS PSL AND PCRV BINDING MOLECULES
    Publication number: 20220177554
    Abstract: This disclosure relates to combination therapies comprising anti-Pseudomonas Psl and PcrV binding molecules and related compositions, for use in prevention and treatment of Pseudomonas infection.
    Type: Application
    Filed: November 15, 2021
    Publication date: June 9, 2022
    Inventors: Antonio DIGIANDOMENICO, Paul WARRENER, Charles STOVER, Bret SELLMAN, Ralph MINTER, Sandrine GUILLARD, Steven RUST, Mladen TOMICH, Vignesh VENKATRAMAN, Reena VARKEY, Li PENG, Melissa DAMSCHRODER, Partha S. CHOWDHURY, Nazzareno DIMASI, Ryan FLEMING, Binyam BEZABEH, Changshou GAO, Godfrey RAINEY, Cuihua GAO
  • METHOD OF CONJUGATING A POLYPEPTIDE
    Publication number: 20220160882
    Abstract: The present disclosure relates to a method of conjugating a compound of formula (I) O 5 R1-Q (ZL-COn-X—N O (I) with a polypeptide comprising at least one thiol group and molecules obtained from said method.
    Type: Application
    Filed: November 16, 2021
    Publication date: May 26, 2022
    Inventors: Ronald James CHRISTIE, Changshou GAO, Nazzareno DIMASI
  • Polynucleotides encoding antibodies or antigen binding fragments thereof that bind pseudomonas perv
    Patent number: 11203633
    Abstract: This disclosure relates to polynucleotides encoding antibodies or antigen binding fragments thereof that bind to Pseudomonas PcrV as well as vectors and host cells comprising the same.
    Type: Grant
    Filed: February 13, 2020
    Date of Patent: December 21, 2021
    Assignee: MedImmune Limited
    Inventors: Antonio Digiandomenico, Paul Warrener, Charles Stover, Bret Sellman, Ralph Minter, Sandrine Guillard, Steven Rust, Mladen Tomich, Vignesh Venkatraman, Reena Varkey, Li Peng, Melissa Damschroder, Partha S. Chowdhury, Nazzareno Dimasi, Ryan Fleming, Binyam Bezabeh, Changshou Gao, Godfrey Rainey, Cuihua Gao
  • METHODS FOR PREPARING ANTIBODIES WITH A DEFINED GLYCOSYLATION PATTERN
    Publication number: 20210214419
    Abstract: The present disclosure relates to a process for preparing antibodies with a defined glycosylation pattern, in particular antibodies with a glycan terminating in an N-acetylglucosamine. The antibodies of the disclosure are suitable for use in a process to conjugate a payload thereto. The disclosure also extends to molecules obtained and obtainable from the process disclosed herein, novel molecules and intermediates, compositions comprising said molecules and uses of the molecules and compositions, particularly in treatment, for example in the treatment of cancer.
    Type: Application
    Filed: January 26, 2017
    Publication date: July 15, 2021
    Inventors: CHANGSHOU GAO, Pamela THOMPSON, Dorin TOADER, Nazzareno DIMASI
  • ANTI-VEGF-A ANTIBODIES AND USES THEREOF
    Publication number: 20210147531
    Abstract: The present invention relates to antibodies having activity against a vascular endothelial growth factor (VEGF), and methods of making and using such antibodies.
    Type: Application
    Filed: January 19, 2021
    Publication date: May 20, 2021
    Applicant: MEDIMMUNE LIMITED
    Inventors: Ching Ching Leow, Nazzareno Dimasi, Karen Coffman, Ping Tsui, Changshou Gao, Mario A. Cepeda, Adrian Schwartz Mittelman
  • Anti-VEGF-A antibodies and uses thereof
    Patent number: 10919958
    Abstract: The present invention relates to antibodies having activity against a vascular endothelial growth factor (VEGF), and methods of making and using such antibodies.
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: February 16, 2021
    Assignee: MEDIMMUNE LIMITED
    Inventors: Ching Ching Leow, Nazzareno Dimasi, Karen Coffman, Ping Tsui, Changshou Gao, Mario A. Cepeda, Adrian Schwartz Mittelman
  • ANTI-VEGF-A AND ANTI-ANG2 ANTIBODIES AND USES THEREOF
    Publication number: 20210040194
    Abstract: The present invention relates to bispecific antibodies having activity against a vascular endothelial growth factor (VEGF) and an angiopoietin (ANG), and methods of making and using such bispecific antibodies.
    Type: Application
    Filed: October 14, 2020
    Publication date: February 11, 2021
    Applicant: MEDIMMUNE LIMITED
    Inventors: Ching Ching Leow, Nazzareno Dimasi, Karen Coffman, Ryan Fleming, Ping Tsui, Changshou Gao, Mario A. Cepeda, Adrian Schwartz Mittelman
  • Anti-VEGF-A and anti-ANG2 antibodies and uses thereof
    Patent number: 10836819
    Abstract: The present invention relates to bispecific antibodies having activity against a vascular endothelial growth factor (VEGF) and an angiopoietin (ANG), and methods of making and using such bispecific antibodies.
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: November 17, 2020
    Assignee: MEDIMMUNE LIMITED
    Inventors: Ching Ching Leow, Nazzareno Dimasi, Karen Coffman, Ryan Fleming, Ping Tsui, Changshou Gao, Mario A. Cepeda, Adrian Schwartz Mittelman
  • COMBINATION THERAPIES USING ANTI-PSEUDOMONAS PSL AND PCRV BINDING MOLECULES
    Publication number: 20200317757
    Abstract: This disclosure relates to combination therapies comprising anti-Pseudomonas Psl and PcrV binding molecules and related compositions, for use in prevention and treatment of Pseudomonas infection.
    Type: Application
    Filed: February 13, 2020
    Publication date: October 8, 2020
    Inventors: Antonio DIGIANDOMENICO, Paul WARRENER, Charles STOVER, Bret SELLMAN, Ralph MINTER, Sandrine GUILLARD, Steven RUST, Mladen TOMICH, Vignesh VENKATRAMAN, Reena VARKEY, Li PENG, Melissa DAMSCHRODER, Partha S. CHOWDHURY, Nazzareno DIMASI, Ryan FLEMING, Binyam BEZABEH, Changshou GAO, Godfrey RAINEY, Cuihua GAO
  • PYRROLOBENZODIAZEPINE CONJUGATES
    Publication number: 20200289660
    Abstract: A conjugate of formula I, wherein Ab is a modified antibody having at least one free conjugation site on each heavy chain.
    Type: Application
    Filed: November 13, 2018
    Publication date: September 17, 2020
    Inventors: Philip Wilson HOWARD, Luke MASTERSON, Thais CAILLEAU, Nazzareno DIMASI, Jason WHITE
  • PYRROLOBENZODIAZEPINE CONJUGATES
    Publication number: 20200247823
    Abstract: A conjugate of formula (I) wherein Ab is a modified antibody having at least one free conjugation site on each heavy chain.
    Type: Application
    Filed: August 17, 2018
    Publication date: August 6, 2020
    Inventors: Nazzareno DIMASI, Philip Wilson HOWARD, Luke MASTERSON, Arnaud Charles TIBERGHIEN, Balakumar VIJAYAKRISHNAN, Jason WHITE
  • Combination therapies using anti-pseudomonas PSL and PCRV binding molecules
    Patent number: 10597439
    Abstract: This disclosure relates to combination therapies comprising anti-Pseudomonas Psl and PcrV binding molecules and related compositions, for use in prevention and treatment of Pseudomonas infection.
    Type: Grant
    Filed: November 6, 2012
    Date of Patent: March 24, 2020
    Assignee: MEDIMMUNE LIMITED
    Inventors: Antonio Digiandomenico, Paul Warrener, Charles Stover, Bret Sellman, Ralph Minter, Sandrine Guillard, Steven Rust, Mladen Tomich, Vignesh Venkatraman, Reena Varkey, Li Peng, Melissa Damschroder, Partha Chowdhury, Nazzareno Dimasi, Ryan Fleming, Binyam Bezabeh, Changshou Gao, Godfrey Rainey, Cuihua Gao
  • ANTI-VEGF-A ANTIBODIES AND USES THEREOF
    Publication number: 20190202903
    Abstract: The present invention relates to antibodies having activity against a vascular endothelial growth factor (VEGF), and methods of making and using such antibodies.
    Type: Application
    Filed: August 22, 2017
    Publication date: July 4, 2019
    Inventors: Ching Ching Leow, Nazzareno Dimasi, Karen Coffman, Ping Tsui, Changshou Gao, Mario A. Cepeda, Adrian Schwartz Mittelman
  • ANTI-VEGF-A AND ANTI-ANG2 ANTIBODIES AND USES THEREOF
    Publication number: 20190194308
    Abstract: The present invention relates to bispecific antibodies having activity against a vascular endothelial growth factor (VEGF) and an angiopoietin (ANG), and methods of making and using such bispecific antibodies.
    Type: Application
    Filed: August 22, 2017
    Publication date: June 27, 2019
    Inventors: Ching Ching Leow, Nazzareno Dimasi, Karen Coffman, Ryan Fleming, Ping Tsui, Changshou Gao, Mario A. Cepeda, Adrian Schwartz Mittelman