Patents by Inventor Neal K. Devaraj

Neal K. Devaraj has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enzymatic modification of nucleic acids
    Patent number: 11267842
    Abstract: There are provided, inter alia, methods and reagents for labeling nucleic acids.
    Type: Grant
    Filed: March 3, 2016
    Date of Patent: March 8, 2022
    Assignee: The Regents of the University of California
    Inventors: Neal K. Devaraj, Seth C. Alexander
  • Functionalized 1,2,4,5-tetrazine compounds for use in bioorthogonal coupling reactions
    Patent number: 11208390
    Abstract: The present application relates to functionalized 1,2,4,5-tetrazine compounds. The compounds are useful in compositions and methods using bioorthogonal inverse electron demand Diels-Alder cycloaddition reactions for the rapid and specific covalent delivery of a “payload” to a ligand bound to a biological target.
    Type: Grant
    Filed: March 2, 2020
    Date of Patent: December 28, 2021
    Assignee: The General Hospital Corporation
    Inventors: Scott A. Hilderbrand, Neal K. Devaraj, Ralph Weissleder, Mark R. Karver
  • In situ lipid synthesis for protein reconstitution
    Patent number: 11052044
    Abstract: Described herein, inter alia, are compositions and methods useful for the reconstitution of membrane proteins.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: July 6, 2021
    Assignee: The Regents of the University of California
    Inventors: Roberto Javier Brea Fernandez, Christian Cole, Neal K. Devaraj, Brent Lyda, Roger Sunahara
  • FUNCTIONALIZED 1,2,4,5-TETRAZINE COMPOUNDS FOR USE IN BIOORTHOGONAL COUPLING REACTIONS
    Publication number: 20200199085
    Abstract: The present application relates to functionalized 1,2,4,5-tetrazine compounds. The compounds are useful in compositions and methods using bioorthogonal inverse electron demand Diels-Alder cycloaddition reactions for the rapid and specific covalent delivery of a “payload” to a ligand bound to a biological target.
    Type: Application
    Filed: March 2, 2020
    Publication date: June 25, 2020
    Inventors: Scott A. Hilderbrand, Neal K. Devaraj, Ralph Weissleder, Mark R. Karver
  • Functionalized 1,2,4,5-tetrazine compounds for use in bioorthogonal coupling reactions
    Patent number: 10611738
    Abstract: The present application relates to functionalized 1,2,4,5-tetrazine compounds. The compounds are useful in compositions and methods using bioorthogonal inverse electron demand Diels-Alder cycloaddition reactions for the rapid and specific covalent delivery of a “payload” to a ligand bound to a biological target.
    Type: Grant
    Filed: February 26, 2018
    Date of Patent: April 7, 2020
    Assignee: The General Hospital Corporation
    Inventors: Scott A. Hilderbrand, Neal K. Devaraj, Ralph Weissleder, Mark R. Karver
  • IN SITU LIPID SYNTHESIS FOR PROTEIN RECONSTITUTION
    Publication number: 20200022915
    Abstract: Described herein, inter alia, are compositions and methods useful for the reconstitution of membrane proteins.
    Type: Application
    Filed: March 1, 2018
    Publication date: January 23, 2020
    Inventors: Roberto Javier Brea Fernandez, Christian Cole, Neal K. Devaraj, Brent Lyda, Roger Sunahara
  • FUNCTIONALIZED 1,2,4,5-TETRAZINE COMPOUNDS FOR USE IN BIOORTHOGONAL COUPLING REACTIONS
    Publication number: 20190040021
    Abstract: The present application relates to functionalized 1,2,4,5-tetrazine compounds. The compounds are useful in compositions and methods using bioorthogonal inverse electron demand Diels-Alder cycloaddition reactions for the rapid and specific covalent delivery of a “payload” to a ligand bound to a biological target.
    Type: Application
    Filed: February 26, 2018
    Publication date: February 7, 2019
    Inventors: Scott A. Hilderbrand, Neal K. Devaraj, Ralph Weissleder, Mark R. Karver
  • HIGHLY SENSITIVE DETECTION OF BIOMOLECULES USING PROXIMITY INDUCED BIOORTHOGONAL REACTIONS
    Publication number: 20180244643
    Abstract: There provided, inter alia, reagents and methods for modulation fluorescence of a tetrazine containing compound and/or a dienophile-containing compound. There is provided a method of detecting binding of a first affmity ligand and a second affinity ligand, the method includes the follow steps. Contacting a tetrazine-containing compound with a dienophile-containing compound, the tetrazine-containing compound comprising a first affinity ligand covalently attached to a tetrazine moiety and the dienophile-containing comprising a second affmity ligand covalently attached to a dienophile moiety.
    Type: Application
    Filed: December 30, 2015
    Publication date: August 30, 2018
    Inventors: Neal K. Devaraj, Haoxing Wu
  • ENZYMATIC MODIFICATION OF NUCLEIC ACIDS
    Publication number: 20180148764
    Abstract: There are provided, inter alia, methods and reagents for labeling nucleic acids.
    Type: Application
    Filed: March 3, 2016
    Publication date: May 31, 2018
    Inventors: Neal K. Devaraj, Seth C. Alexander
  • Functionalized 1,2,4,5-tetrazine compounds for use in bioorthogonal coupling reactions
    Patent number: 9902705
    Abstract: The present application relates to functionalized 1,2,4,5-tetrazine compounds. The compounds are useful in compositions and methods using bioorthogonal inverse electron demand Diels-Alder cycloaddition reactions for the rapid and specific covalent delivery of a “payload” to a ligand bound to a biological target.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: February 27, 2018
    Assignee: The General Hospital Corporation
    Inventors: Scott A. Hilderbrand, Neal K. Devaraj, Ralph Weissleder, Mark R. Karver
  • Tetrazines and method of synthezising the same
    Patent number: 9533957
    Abstract: Provided herein, inter alia, are compositions and methods of synthesis and detection of tetrazines, e.g., a tetrazine of formula and diazonorcaradienes.
    Type: Grant
    Filed: October 6, 2014
    Date of Patent: January 3, 2017
    Assignee: The Regents of the University of California
    Inventors: Neal K. Devaraj, Jun Yang
  • TETRAZINE-CONTAINING COMPOUNDS AND SYNTHETIC METHODS THEREOF
    Publication number: 20160223559
    Abstract: Described herein are tetrazine derivatives and efficient synthetic methods of synthesis thereof using elimination-Heck cascade reaction. Provided herein is the synthesis of conjugated tetrazines from the tetrazine derivatives. Also provided herein are methods of use of the conjugated tetrazines as fluorogenic probes for live-cell imaging.
    Type: Application
    Filed: February 2, 2016
    Publication date: August 4, 2016
    Inventors: Neal K. Devaraj, Haoxing Wu, Jun Yang
  • FUNCTIONALIZED 1,2,4,5-TETRAZINE COMPOUNDS FOR USE IN BIOORTHOGONAL COUPLING REACTIONS
    Publication number: 20150246893
    Abstract: The present application relates to functionalized 1,2,4,5-tetrazine compounds. The compounds are useful in compositions and methods using bioorthogonal inverse electron demand Diels-Alder cycloaddition reactions for the rapid and specific covalent delivery of a “payload” to a ligand bound to a biological target.
    Type: Application
    Filed: March 14, 2013
    Publication date: September 3, 2015
    Applicant: The General Hospital Corporation
    Inventors: Neal K. Devaraj, Mark R. Karver, Scott A. Hilderbrand, Ralph Weissleder
  • NOVEL TETRAZINES AND METHOD OF SYNTHEZISING THE SAME
    Publication number: 20150099277
    Abstract: Provided herein, inter alia, are compositions and methods of synthesis and detection of tetrazines and diazonorcaradienes.
    Type: Application
    Filed: October 6, 2014
    Publication date: April 9, 2015
    Inventors: Neal K. Devaraj, Jun Yang, Jolita Seckute
  • Compositions and methods for delivering a substance to a biological target
    Patent number: 8900549
    Abstract: The present application provides compositions and methods using bioorthogonal inverse electron demand Diels-Alder cycloaddition reaction for rapid and specific covalent delivery of a “payload” to a ligand bound to a biological target.
    Type: Grant
    Filed: November 2, 2009
    Date of Patent: December 2, 2014
    Assignee: The General Hospital Corporation
    Inventors: Scott A. Hilderbrand, Neal K. Devaraj, Ralph Weissleder
  • Preparation of azide-modified carbon surfaces for coupling to various species
    Patent number: 8592565
    Abstract: The invention relates to carbon surfaces modified with one or more azide groups. The invention also relates to methods of modifying carbon surfaces with one or more azide groups.
    Type: Grant
    Filed: January 10, 2008
    Date of Patent: November 26, 2013
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Christopher E. D. Chidsey, Anando Devadoss, Neal K. Devaraj
  • COMPOSITIONS AND METHODS FOR DELIVERING A SUBSTANCE TO A BIOLOGICAL TARGET
    Publication number: 20110268654
    Abstract: The present application provides compositions and methods using bioorthogonal inverse electron demand Diels-Alder cycloaddition reaction for rapid and specific covalent delivery of a “payload” to a ligand bound to a biological target.
    Type: Application
    Filed: November 2, 2009
    Publication date: November 3, 2011
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Scott A. Hilderbrand, Neal K. Devaraj, Ralph Weissleder
  • Preparation of azide-modified carbon surfaces for coupling to various species
    Publication number: 20110184196
    Abstract: The invention relates to carbon surfaces modified with one or more azide groups. The invention also relates to methods of modifying carbon surfaces with one or more azide groups.
    Type: Application
    Filed: January 10, 2008
    Publication date: July 28, 2011
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Christopher E.D. Chidsey, Anando Devadoss, Neal K. Devaraj