Patents by Inventor Nedra Karunaratne

Nedra Karunaratne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptide sequence design and use thereof for peptide-mediated siRNA delivery
    Patent number: 9950073
    Abstract: Peptides that have been found to facilitate the delivery of siRNA molecules into cells and to function in siRNA mediated silencing of cellular targets are disclosed. Complexes that include one of the peptides and a cargo molecule are disclosed, wherein the peptide and the cargo molecule are coupled non-covalently. Also disclosed are methods of producing and using the peptides/complexes.
    Type: Grant
    Filed: January 17, 2017
    Date of Patent: April 24, 2018
    Assignees: Positec Power Tools (Suzhou) Co. Ltd., Pu Chen
    Inventors: Pu Chen, Mousa Jafari, Wen Xu, Baoling Chen, Ran Pan, Nedra Karunaratne
  • Peptide Sequence Design and Use Thereof For Peptide-Mediated siRNA Delivery
    Publication number: 20170128582
    Abstract: Peptides that have been found to facilitate the delivery of siRNA molecules into cells and to function in siRNA mediated silencing of cellular targets are disclosed. Complexes that include one of the peptides and a cargo molecule are disclosed, wherein the peptide and the cargo molecule are coupled non-covalently. Also disclosed are methods of producing and using the peptides/complexes.
    Type: Application
    Filed: January 17, 2017
    Publication date: May 11, 2017
    Inventors: PU CHEN, MOUSA JAFARI, WEN XU, BAOLING CHEN, RAN PAN, NEDRA KARUNARATNE
  • Peptide sequence design and use thereof for peptide-mediated siRNA delivery
    Patent number: 9603946
    Abstract: Peptides that have been found to facilitate the delivery of siRNA molecules into cells and to function in siRNA mediated silencing of cellular targets are disclosed. Complexes that include one of the peptides and a cargo molecule are disclosed, wherein the peptide and the cargo molecule are coupled non-covalently. Also disclosed are methods of producing and using the peptides/complexes.
    Type: Grant
    Filed: December 29, 2015
    Date of Patent: March 28, 2017
    Assignees: Positec Power Tools (Suzhou) Co LTD
    Inventors: Pu Chen, Mousa Jafari, Wen Xu, Baoling Chen, Ran Pan, Nedra Karunaratne
  • Peptide Sequence Design and Use Thereof For Peptide-Mediated siRNA Delivery
    Publication number: 20160175456
    Abstract: Peptides that have been found to facilitate the delivery of siRNA molecules into cells and to function in siRNA mediated silencing of cellular targets are disclosed. Complexes that include one of the peptides and a cargo molecule are disclosed, wherein the peptide and the cargo molecule are coupled non-covalently. Also disclosed are methods of producing and using the peptides/complexes.
    Type: Application
    Filed: December 29, 2015
    Publication date: June 23, 2016
    Inventors: Pu Chen, Mousa Jafari, Wen Xu, Baoling Chen, Ran Pan, Nedra Karunaratne
  • Peptide sequence design and use thereof for peptide-mediated siRNA delivery
    Patent number: 9259483
    Abstract: The invention provides, in one aspect, peptides and a complex comprising one of the peptides and a cargo molecule, wherein the peptide and the cargo molecule are coupled by non-covalently. The peptides of the invention were found to facilitate the delivery of siRNA molecules into cells and to function in siRNA mediated silencing of cellular targets.
    Type: Grant
    Filed: November 23, 2012
    Date of Patent: February 16, 2016
    Assignee: Positec Power Tools (Suzhou) Co Ltd
    Inventors: Pu Chen, Mousa Jafari, Wen Xu, Baoling Chen, Ran Pan, Nedra Karunaratne
  • PEPTIDE SEQUENCE DESIGN AND USE THEREOF FOR PEPTIDE-MEDIATED siRNA DELIVERY
    Publication number: 20140350082
    Abstract: The invention provides, in one aspect, peptides and a complex comprising one of the peptides and a cargo molecule, wherein the peptide and the cargo molecule are coupled by non-covalently. The peptides of the invention were found to facilitate the delivery of siRNA molecules into cells and to function in siRNA mediated silencing of cellular targets.
    Type: Application
    Filed: November 23, 2012
    Publication date: November 27, 2014
    Inventors: Pu Chen, Mousa Jafari, Wen Xu, Baoling Chen, Ran Pan, Nedra Karunaratne
  • METHOD AND COMPOSITION FOR THERMALLY STABILIZING VITAMIN C WITHIN NANO LAYERS OF MONTMORILLONITE CLAY
    Publication number: 20110184006
    Abstract: A thermally stable Vitamin C composition containing montmorillonite, an organic acid containing L-ascorbic acid or a derivative thereof, a divalent cation present within nanolayers of the montmorillonite, wherein the organic acid is combined with the divalent cation within the nanolayers to form an organic acid-montmorillonite chelate.
    Type: Application
    Filed: January 28, 2010
    Publication date: July 28, 2011
    Applicant: NATIONAL RESEARCH COUNCIL OF SRI LANKA
    Inventors: Chandhi S. Goonesekara, Vajira Seneviratne, D. Nedra Karunaratne, Veranja Karunaratne
  • Antimicrobial cationic peptides
    Patent number: 6906035
    Abstract: A novel class of cationic peptides having antimicrobial activity is provided. Examples of such peptides include NH2-KWKSFIKKLTTAVKKVLTTGLPALIS-COOH (SEQ ID NO:1) and NH2-KWKSFIKKLTSAAKKVVTTAKPLISS-COOH (SEQ ID NO:2). Also provided are methods for inhibiting the growth of bacteria utilizing the peptides of the invention. The peptides are particularly useful for inhibiting endotoxemia in a subject.
    Type: Grant
    Filed: October 15, 2002
    Date of Patent: June 14, 2005
    Assignee: The University of British Columbia
    Inventors: Robert E. W. Hancock, Nedra Karunaratne
  • Antimicrobial cationic peptides
    Publication number: 20030176337
    Abstract: A novel class of cationic peptides having antimicrobial activity is provided. Examples of such peptides include NH2—KWKSFIKKLTTAVKKVLTTGLPALIS—COOH (SEQ ID NO: 1) and NH2—KWKSFIKKLTSAAKKVVTTAKPLISS—COOH (SEQ ID NO: 2). Also provided are methods for inhibiting the growth of bacteria utilizing the peptides of the invention. The peptides are particularly useful for inhibiting endotoxemia in a subject.
    Type: Application
    Filed: October 15, 2002
    Publication date: September 18, 2003
    Applicant: The University of British Columbia
    Inventors: Robert E.W. Hancock, Nedra Karunaratne
  • Antimicrobial cationic peptides
    Patent number: 6465429
    Abstract: A novel class of cationic peptides having antimicrobial activity is provided. Examples of such peptides include [NH2]kWKSFIKKLTTAVKKVLTTGLPALIS[COOH] (SEQ ID NO:1) and [NH2]KWKSFIKKLTSAAKKVVTTAKPLISS[COOH] (SEQ ID NO:2). Also provided are methods for inhibiting the growth of bacteria utilizing the peptides of the invention. The peptides are particularly useful for inhibiting endotoxemia in a subject.
    Type: Grant
    Filed: June 13, 2000
    Date of Patent: October 15, 2002
    Assignee: The University of British Columbia
    Inventors: Robert E. W. Hancock, Nedra Karunaratne
  • Antimicrobial cationic peptides
    Patent number: 6297215
    Abstract: A novel class of cationic peptides having antimicrobial activity is provided. Examples of such peptides include NH2-KWKSFIKKLTTAVKKVLTTGLPALIS-COOH (SEQ ID NO:1) and NH2-KWKSFIKKLTSAAKKVVTTAKPLISS-COOH (SEQ ID NO:2). Also provided are methods for inhibiting the growth of bacteria utilizing the peptides of the invention. The peptides are particularly useful for inhibiting endotoxemia in a subject.
    Type: Grant
    Filed: May 7, 1999
    Date of Patent: October 2, 2001
    Assignee: The University of British Columbia
    Inventors: Robert E. W. Hancock, Nedra Karunaratne
  • Antimicrobial cationic peptides
    Patent number: 6057291
    Abstract: A novel class of cationic peptides having antimicrobial activity is provided. Examples of such peptides include NH.sub.2 --KWKSFIKKLTTAVKKVLTTGLPALIS--COOH (SEQ ID NO:1) and NH.sub.2 --KWKSFIKKLTSAAKKVVTTAKPLISS--COOH (SEQ ID NO:2). Also provided are methods for inhibiting the growth of bacteria utilizing the peptides of the invention. The peptides are particularly useful for inhibiting endotoxemia in a subject.
    Type: Grant
    Filed: December 10, 1996
    Date of Patent: May 2, 2000
    Assignee: University of British Columbia
    Inventors: Robert E. W. Hancock, Nedra Karunaratne
  • Antimicrobial cationic peptides
    Patent number: 6040435
    Abstract: A novel class of cationic peptides having antimicrobial activity is provided. Examples of such peptides includeNH.sub.2 -KWKSFIKKLTTAVKKVLTTGLPALIS-COOH (SEQ ID NO:1)andNH.sub.2 -KWKSFIKKLTSAAKKVVTTAKPLISS-COOH. (SEQ ID NO:2)Also provided are methods for inhibiting the growth of bacteria utilizing the peptides of the invention. The peptides are particularly useful for inhibiting endotoxemia in a subject.
    Type: Grant
    Filed: May 31, 1996
    Date of Patent: March 21, 2000
    Assignee: University of British Columbia
    Inventors: Robert E. W. Hancock, Nedra Karunaratne
  • Antimicrobial cationic peptides
    Patent number: 5877274
    Abstract: A novel class of cationic peptides having antimicrobial activity is provided. Examples of such peptides include NH.sub.2 -KWKSFIKKLTTAVKKVLTTGLPALIS-COOH (SEQ ID NO:1) and NH.sub.2 -KWKSFIKKLTSAAKKVVTTAKPLISS-COOH (SEQ ID NO:2).
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: March 2, 1999
    Assignee: University of British Columbia
    Inventors: Robert E. W. Hancock, Nedra Karunaratne