Patents by Inventor Neel H. Shah

Neel H. Shah has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SPLIT INTEINS, CONJUGATES AND USES THEREOF
    Publication number: 20220098293
    Abstract: Disclosed herein are split inteins, fused proteins of split inteins, and methods of using split inteins to efficiently purify and modify proteins of interest.
    Type: Application
    Filed: October 1, 2021
    Publication date: March 31, 2022
    Inventors: Tom W. Muir, Miquel Vila-Perello, Zhihua Liu, Neel H. Shah
  • SPLIT INTEINS WITH EXCEPTIONAL SPLICING ACTIVITY
    Publication number: 20210371467
    Abstract: Embodiments of the present invention relate to inteins, split inteins, compositions comprising inteins and methods for use of these.
    Type: Application
    Filed: June 30, 2021
    Publication date: December 2, 2021
    Inventors: Tom W. MUIR, Adam J. STEVENS, Neel H. SHAH
  • Method using split inteins to generate protein conjugates
    Patent number: 11161899
    Abstract: Disclosed herein are split inteins, fused proteins of split inteins, and methods of using split inteins to efficiently purify and modify proteins of interest.
    Type: Grant
    Filed: November 21, 2019
    Date of Patent: November 2, 2021
    Assignee: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Tom W. Muir, Miquel Vila-Perello, Zhihua Liu, Neel H. Shah
  • Split inteins with exceptional splicing activity
    Patent number: 11142550
    Abstract: Embodiments of the present invention relate to inteins, split inteins, compositions comprising inteins and methods for use of these.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: October 12, 2021
    Assignee: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Tom W. Muir, Adam J. Stevens, Neel H. Shah
  • Split inteins with exceptional splicing activity
    Patent number: 11084849
    Abstract: Embodiments of the present invention relate to inteins, split inteins, compositions comprising inteins and methods for use of these.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: August 10, 2021
    Assignee: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Tom W. Muir, Adam J. Stevens, Neel H. Shah
  • SPLIT INTEINS, CONJUGATES AND USES THEREOF
    Publication number: 20200087388
    Abstract: Disclosed herein are split inteins, fused proteins of split inteins, and methods of using split inteins to efficiently purify and modify proteins of interest.
    Type: Application
    Filed: November 21, 2019
    Publication date: March 19, 2020
    Inventors: Tom W. Muir, Miquel Vila-Perello, Zhihua Liu, Neel H. Shah
  • SPLIT INTEINS WITH EXCEPTIONAL SPLICING ACTIVITY
    Publication number: 20200055900
    Abstract: Embodiments of the present invention relate to inteins, split inteins, compositions comprising inteins and methods for use of these.
    Type: Application
    Filed: January 27, 2017
    Publication date: February 20, 2020
    Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Tom W. MUIR, Adam J. STEVENS, Neel H. SHAH
  • Method of using split inteins, conjugates to generate protein conjugates
    Patent number: 10526401
    Abstract: Disclosed herein are split inteins, fused proteins of split inteins, and methods of using split inteins to efficiently purify and modify proteins of interest.
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: January 7, 2020
    Assignee: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Tom W. Muir, Miquel Vila-Perello, Zhihua Liu, Neel H. Shah
  • Split Inteins, Conjugates and Uses Thereof
    Publication number: 20180057577
    Abstract: Disclosed herein are split inteins, fused proteins of split inteins, and methods of using split inteins to efficiently purify and modify proteins of interest.
    Type: Application
    Filed: November 10, 2017
    Publication date: March 1, 2018
    Inventors: Tom W. Muir, Miquel Vila-Perello, Zhihua Liu, Neel H. Shah
  • SPLIT INTEINS, CONJUGATES AND USES THEREOF
    Publication number: 20150344549
    Abstract: Disclosed herein are split inteins, fused proteins of split inteins, and methods of using split inteins to efficiently purify and modify proteins of interest. Thus, provided herein are fusion proteins of a polypeptide and a split intein N-fragment, or variant thereof, as described below in greater detail. Also provided are complexes of the fusion protein and a split intein C-fragment or variant thereof as described in detail below. The complex of the fusion protein and C-fragment or variant thereof can be via a covalent interaction between the fusion protein and C-fragment or variant or via a noncovalent interaction (e.g., ionic, H-bonding, and/or van der Waals interaction). Further provided herein are split intein C-fragments or variants thereof.
    Type: Application
    Filed: June 24, 2013
    Publication date: December 3, 2015
    Inventors: Tom W. Muir, Miquel Vila-Perello, Zhihua Liu, Neel H. Shah