Patents by Inventor Neel Satish Joshi

Neel Satish Joshi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENGINEERED BACTERIA SECRETING THERAPEUTIC PROTEINS AND METHODS OF USE THEREOF
    Publication number: 20240165168
    Abstract: Engineered bacteria that secrete therapeutic polypeptides, pharmaceutical compositions comprising the bacteria, methods for producing recombinant polypeptides, and methods for using the bacteria for diagnostic and therapeutic purposes are provided.
    Type: Application
    Filed: November 29, 2023
    Publication date: May 23, 2024
    Inventors: Peter Q. Nguyen, Neel Satish Joshi
  • Engineered bacteria secreting therapeutic proteins and methods of use thereof
    Patent number: 11850268
    Abstract: Engineered bacteria that secrete therapeutic polypeptides, pharmaceutical compositions comprising the bacteria, methods for producing recombinant polypeptides, and methods for using the bacteria for diagnostic and therapeutic purposes are provided.
    Type: Grant
    Filed: March 18, 2022
    Date of Patent: December 26, 2023
    Assignee: President and Fellows of Harvard College
    Inventors: Peter Q. Nguyen, Neel Satish Joshi
  • Electrically conductive protein nanofibers and biofilms
    Patent number: 11643443
    Abstract: Methods of making engineered protein-based materials, nanofibers, and biofilms from bacterial amyloid-based structures that are capable of mediating long-range electron transport are provided.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: May 9, 2023
    Assignee: President and Fellows of Harvard College
    Inventors: Neel Satish Joshi, Noémie-Manuelle Dorval Courchesne
  • REFILLABLE DRUG DELIVERY DEVICES AND METHODS OF USE THEREOF
    Publication number: 20220401562
    Abstract: The present invention provides refillable drug delivery systems, as well as methods of refilling the systems, and methods of using them to treat diseases.
    Type: Application
    Filed: January 6, 2022
    Publication date: December 22, 2022
    Inventors: Yevgeny Brudno, Cathal J. Kearney, Eduardo Alexandre Barros E Silva, Michael Aizenberg, Brian Kwee, Rajiv Desai, Neel Satish Joshi, David J. Mooney
  • ENGINEERED BACTERIA SECRETING THERAPEUTIC PROTEINS AND METHODS OF USE THEREOF
    Publication number: 20220280575
    Abstract: Engineered bacteria that secrete therapeutic polypeptides, pharmaceutical compositions comprising the bacteria, methods for producing recombinant polypeptides, and methods for using the bacteria for diagnostic and therapeutic purposes are provided.
    Type: Application
    Filed: March 18, 2022
    Publication date: September 8, 2022
    Inventors: Peter Q. Nguyen, Neel Satish Joshi
  • Method of making recombinant silk and silk-amyloid hybrid proteins using bacteria
    Patent number: 11365225
    Abstract: Methods of making recombinant secretion of silk and silk-amyloid proteins using bacteria are provided.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: June 21, 2022
    Inventors: Neel Satish Joshi, Peter Quoc Nguyen
  • Genetic reprogramming of bacterial biofilms
    Patent number: 11352397
    Abstract: Described herein are methods and compositions relating to engineered curli fibers, e.g. CsgA polypeptide. In some embodiments, the methods and compositions described herein relate to functionalized biofilms.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: June 7, 2022
    Inventors: Neel Satish Joshi, Peter Q. Nguyen, Zsofia Magarian
  • Biosynthetic amyloid-based materials displaying functional protein sequences
    Patent number: 11286491
    Abstract: Methods of making biofilms having non-native functional polypeptides attached thereto are provided.
    Type: Grant
    Filed: February 10, 2020
    Date of Patent: March 29, 2022
    Assignee: President and Fellows of Harvard College
    Inventors: Neel Satish Joshi, Peter Q. Nguyen, Anna M. Duraj-Thatte, Pichet Praveschotinunt
  • Engineered bacteria secreting therapeutic proteins and methods of use thereof
    Patent number: 11278577
    Abstract: Engineered bacteria that secrete therapeutic polypeptides, pharmaceutical compositions comprising the bacteria, methods for producing recombinant polypeptides, and methods for using the bacteria for diagnostic and therapeutic purposes are provided.
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: March 22, 2022
    Assignee: President and Fellows of Harvard College
    Inventors: Peter Q. Nguyen, Neel Satish Joshi
  • METHOD OF MAKING RECOMBINANT SILK AND SILK-AMYLOID HYBRID PROTEINS USING BACTERIA
    Publication number: 20210380992
    Abstract: Disclosed are methods of making recombinant secretion of silk and collagen proteins, and amyloid fusions thereof, using bacteria.
    Type: Application
    Filed: May 14, 2021
    Publication date: December 9, 2021
    Inventors: Neel Satish Joshi, Peter Quoc Nguyen, Noemie-Manuelle Dorval Courchesne, Zahra Abdali
  • Methods of making gels and films using curli nanofibers
    Patent number: 11098133
    Abstract: Provided are compositions and methods of making hydrogels, aerogels, films and composites directly from a microbial culture or complex mixture using curli nanofibers.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: August 24, 2021
    Inventors: Anna M. Duraj-Thatte, Noémie-Manuelle Dorval Courchesne, Neel Satish Joshi
  • FIBROUS PROTEINACEOUS NETWORKS AND METHODS OF USE THEREOF
    Publication number: 20210163558
    Abstract: Disclosed herein are engineered bacteria that manufacture biofilms from bacterial amyloid structures. These biofilms and biofilm matrices are capable of generating fibrous proteinaceous networks and being used as 3D-printing inks.
    Type: Application
    Filed: June 21, 2019
    Publication date: June 3, 2021
    Inventors: Arjirios Sourlis, Anna Duraj-Thatte, Avinash Manjula Basavanna, Neel Satish Joshi
  • CLICK-CROSSLINKED HYDROGELS AND METHODS OF USE
    Publication number: 20210128790
    Abstract: The present disclosure provides click-crosslinked hydrogels and methods of use.
    Type: Application
    Filed: September 15, 2020
    Publication date: May 6, 2021
    Inventors: Rajiv Desai, Neel Satish Joshi, David J. Mooney, Sandeep T. Koshy, Alexander Stafford
  • Scalable production of genetically engineered nanofibrous macroscopic materials via filtration
    Patent number: 10995114
    Abstract: Provided herein are filtration-based purification methods for amyloid fibers, such as curli fibers, directly from microbial culture, and their fabrication into free-standing thin films. Additionally, methods for recycling amyloid fibers thing films by, for example, disassembly and re-assembly, are disclosed herein.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: May 4, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: Neel Satish Joshi, Noémie-Manuelle Dorval Courchesne, Anna M. Duraj-Thatte, Peter Q. Nguyen
  • Click-crosslinked hydrogels and methods of use
    Patent number: 10821208
    Abstract: The present disclosure provides click-crosslinked hydrogels and methods of use.
    Type: Grant
    Filed: April 6, 2015
    Date of Patent: November 3, 2020
    Assignee: President and Fellows of Harvard College
    Inventors: Rajiv Desai, Neel Satish Joshi, David J. Mooney, Sandeep T. Koshy, Alexander G. Stafford
  • METHOD OF MAKING RECOMBINANT SILK AND SILK-AMYLOID HYBRID PROTEINS USING BACTERIA
    Publication number: 20200291078
    Abstract: Methods of making recombinant secretion of silk and silk-amyloid proteins using bacteria are provided.
    Type: Application
    Filed: November 18, 2016
    Publication date: September 17, 2020
    Inventors: Neel Satish Joshi, Peter Quoc Nguyen
  • GENETIC REPROGRAMMING OF BACTERIAL BIOFILMS
    Publication number: 20200255480
    Abstract: Described herein are methods and compositions relating to engineered curli fibers, e.g. CsgA polypeptide. In some embodiments, the methods and compositions described herein relate to functionalized biofilms.
    Type: Application
    Filed: December 13, 2019
    Publication date: August 13, 2020
    Inventors: Neel Satish Joshi, Peter Q. Nguyen, Zsofia Magarian
  • BIOSYNTHETIC AMYLOID-BASED MATERIALS DISPLAYING FUNCTIONAL PROTEIN SEQUENCES
    Publication number: 20200248190
    Abstract: Methods of making biofilms having non-native functional polypeptides attached thereto are provided.
    Type: Application
    Filed: February 10, 2020
    Publication date: August 6, 2020
    Inventors: Neel Satish Joshi, Peter Q. Nguyen, Anna M. Duraj-Thatte, Pichet Praveschotinunt
  • REFILLABLE DRUG DELIVERY DEVICES AND METHODS OF USE THEREOF
    Publication number: 20200197526
    Abstract: The present invention provides refillable drug delivery systems, as well as methods of refilling the systems, and methods of using them to treat diseases.
    Type: Application
    Filed: December 6, 2019
    Publication date: June 25, 2020
    Inventors: Yevgeny Brudno, Cathal J. Kearney, Eduardo Alexandre Barros E Silva, Michael Aizenberg, Brian Kwee, Rajiv Desai, Neel Satish Joshi, David J. Mooney
  • Genetic reprogramming of bacterial biofilms
    Patent number: 10550160
    Abstract: Described herein are methods and compositions relating to engineered curli fibers, e.g. CsgA polypeptide. In some embodiments, the methods and compositions described herein relate to functionalized biofilms.
    Type: Grant
    Filed: November 9, 2017
    Date of Patent: February 4, 2020
    Assignee: President and Fellows of Harvard College
    Inventors: Neel Satish Joshi, Peter Q. Nguyen, Zsofia Magarian