Patents by Inventor Neena PYZOCHA

Neena PYZOCHA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL CAS13B ORTHOLOGUES CRISPR ENZYMES AND SYSTEMS
    Publication number: 20240018494
    Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting Cas13b effector protein and at least one targeting nucleic acid component like a guide RNA or crRNA.
    Type: Application
    Filed: July 10, 2023
    Publication date: January 18, 2024
    Inventors: David Benjamin Turitz Cox, Neena Pyzocha, Feng Zhang
  • Cas13b orthologues CRISPR enzymes and systems
    Patent number: 11739308
    Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting Cas13b effector protein and at least one targeting nucleic acid component like a guide RNA or crRNA.
    Type: Grant
    Filed: March 15, 2018
    Date of Patent: August 29, 2023
    Assignees: The Broad Institute, Inc., Massachusetts Institute of Technology
    Inventors: David Benjamin Turitz Cox, Neena Pyzocha, Feng Zhang
  • METHODS FOR IDENTIFYING CLASS 2 CRISPR-CAS SYSTEMS
    Publication number: 20210166783
    Abstract: Disclosed here is a method of identifying novel CRISPR effectors, comprising: identifying sequences in a genomic or metagenomic database encoding a CRISPR array; identifying one or more Open Reading Frames (ORFs) in said selected sequences within 10 kb of the CRISPR array; discarding all loci encoding proteins which are assigned to known CRISPR-Cas subtypes and, optionally, all loci encoding a protein of less than 700 amino acids; and identifying putative novel CRISPR effectors, and optionally classifying them based on structure analysis.
    Type: Application
    Filed: August 16, 2017
    Publication date: June 3, 2021
    Applicants: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY, RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH
    Inventors: Sergey SHMAKOV, Kira S. MAKAROVA, Yuri I. WOLF, Aaron SMARGON, Neena PYZOCHA, David COX, Winston YAN, David SCOTT, Konstantin SEVERINOV, Feng ZHANG, Eugene V. KOONIN
  • NOVEL CAS13B ORTHOLOGUES CRISPR ENZYMES AND SYSTEMS
    Publication number: 20200131488
    Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting Cas13b effector protein and at least one targeting nucleic acid component like a guide RNA or crRNA.
    Type: Application
    Filed: March 15, 2018
    Publication date: April 30, 2020
    Inventors: David Benjamin Turitz Cox, Neena Pyzocha, Feng Zhang
  • NOVEL CRISPR ENZYMES AND SYSTEMS
    Publication number: 20190093107
    Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA-targeting systems comprising a novel DNA or RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.
    Type: Application
    Filed: April 23, 2018
    Publication date: March 28, 2019
    Inventors: Feng Zhang, Aaron Smargon, Neena PYZOCHA, David Benjamin Turitz Cox, Eric S. Lander