Patents by Inventor Neeraj SALATHIA

Neeraj SALATHIA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND SYSTEMS FOR DETECTING TISSUE CONDITIONS
    Publication number: 20230399685
    Abstract: Provided herein are methods and systems for detecting tissue conditions. In some aspects, levels of one or more markers of a disease or condition and one or more tissue-specific cell-free polynucleotides are quantified, levels are compared to a reference, and it is determined whether the tissue has been damaged by the disease or condition based on the comparing. Systems for performing the methods described herein are also provided.
    Type: Application
    Filed: August 29, 2022
    Publication date: December 14, 2023
    Inventors: Michael NERENBERG, Neeraj SALATHIA, Arkaitz IBARRA, Yue ZHAO
  • CELL-FREE RNA LIBRARY PREPARATIONS
    Publication number: 20220081685
    Abstract: Diverse cDNA libraries derived from cell-free mRNA and methods of preparing the same are provided. The library may be prepared by extracting RNA from a bodily fluid such as serum or plasma, separating the RNA from contaminants, synthesizing cDNA with a reverse transcriptase enzyme, and enriching protein-coding nucleotide sequences. The library may include a multiplicity of transcripts from solid tissues. Cf-RNA can be measured by qPCR, sequencing, or other suitable methods.
    Type: Application
    Filed: April 28, 2021
    Publication date: March 17, 2022
    Inventors: Neeraj Salathia, Michael Nerenberg, Arkaitz Ibarra, Jiali Zhuang
  • Nucleic Acid Sequence Analysis from Single Cells
    Publication number: 20210198659
    Abstract: Presented herein are methods and compositions for multiplexed single cell gene expression analysis. Some methods and compositions include the use of droplets and/or beads bearing unique barcodes such as unique molecular barcodes (UMI).
    Type: Application
    Filed: March 10, 2021
    Publication date: July 1, 2021
    Applicant: Illumina, Inc.
    Inventors: Neeraj Salathia, Jian-Bing Fan, Fiona Kaper, Gordon M. Cann, Arash Jamshidi, Alex Aravanis
  • SPATIAL MAPPING OF NUCLEIC ACID SEQUENCE INFORMATION
    Publication number: 20210130885
    Abstract: Presented are methods and compositions for spatial detection and analysis of nucleic acids in a tissue sample. The methods can enable the characterization of transcriptomes and/or genomic variations in tissues while preserving spatial information about the tissue.
    Type: Application
    Filed: January 11, 2021
    Publication date: May 6, 2021
    Inventors: Alex So, Li Liu, Min-Jui Richard Shen, Neeraj Salathia, Kathryn M. Stephens, Anne Jager, Timothy Wilson, Justin Fullerton, Sean M. Ramirez, Shannon Kaplan, Rigo Pantoja, Bala Murali Venkatesan, Steven Modiano
  • Nucleic acid sequence analysis from single cells
    Patent number: 10975371
    Abstract: Presented herein are methods and compositions for multiplexed single cell gene expression analysis. Some methods and compositions include the use of droplets and/or beads bearing unique barcodes such as unique molecular barcodes (UMI).
    Type: Grant
    Filed: September 15, 2015
    Date of Patent: April 13, 2021
    Assignee: Illumina, Inc.
    Inventors: Neeraj Salathia, Jian-Bing Fan, Fiona Kaper, Gordon M. Cann, Arash Jamshidi, Alex Aravanis
  • Multiplexed Single Cell Gene Expression Analysis Using Template Switch and Tagmentation
    Publication number: 20210079386
    Abstract: Presented herein are methods and compositions for multiplexed single cell gene expression analysis. Some methods and compositions include the use of droplets and/or beads bearing unique barcodes such as unique molecular barcodes (UMI).
    Type: Application
    Filed: October 23, 2020
    Publication date: March 18, 2021
    Applicant: ILLUMINA, INC.
    Inventors: Fiona KAPER, Jian-Bing FAN, Neeraj SALATHIA, Gordon M. CANN, Arash JAMSHIDI, Alex ARAVANIS
  • METHODS AND SYSTEMS FOR DETECTING TISSUE CONDITIONS
    Publication number: 20210054445
    Abstract: Provided herein are methods and systems for detecting tissue conditions. In some aspects, levels of one or more markers of a disease or condition and one or more tissue-specific cell-free polynucleotides are quantified, levels are compared to a reference, and it is determined whether the tissue has been damaged by the disease or condition based on the comparing. Systems for performing the methods described herein are also provided.
    Type: Application
    Filed: March 19, 2020
    Publication date: February 25, 2021
    Inventors: Michael Nerenberg, Neeraj Salathia, Arkaitz Ibarra, Yue Zhao
  • Spatial mapping of nucleic acid sequence information
    Patent number: 10913975
    Abstract: Presented are methods and compositions for spatial detection and analysis of nucleic acids in a tissue sample. The methods can enable the characterization of transcriptomes and/or genomic variations in tissues while preserving spatial information about the tissue.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: February 9, 2021
    Assignee: Illumina, Inc.
    Inventors: Alex So, Li Liu, Min-Jui Richard Shen, Neeraj Salathia, Kathryn M. Stephens, Anne Jager, Timothy Wilson, Justin Fullerton, Sean M. Ramirez, Shannon Kaplan, Rigo Pantoja, Bala Murali Venkatesan, Steven Modiano
  • SPATIAL MAPPING OF NUCLEIC ACID SEQUENCE INFORMATION
    Publication number: 20180245142
    Abstract: Presented are methods and compositions for spatial detection and analysis of nucleic acids in a tissue sample. The methods can enable the characterization of transcriptomes and/or genomic variations in tissues while preserving spatial information about the tissue.
    Type: Application
    Filed: July 21, 2016
    Publication date: August 30, 2018
    Inventors: Alex SO, Li LIU, Min-Jui Richard SHEN, Neeraj SALATHIA, Kathryn M. STEPHENS, Anne JAGER, Timothy WILSON, Justin FULLERTON, Sean M. RAMIREZ, Shannon KAPLAN, Rigo PANTOJA, Bala Murali VENKATESAN, Steven MODIANO
  • MULTIPLEXED SINGLE CELL GENE EXPRESSION ANALYSIS USING TEMPLATE SWITCH AND TAGMENTATION
    Publication number: 20170044525
    Abstract: Presented herein are methods and compositions for multiplexed single cell gene expression analysis. Some methods and compositions include the use of droplets and/or beads bearing unique barcodes such as unique molecular barcodes (UMI).
    Type: Application
    Filed: April 28, 2015
    Publication date: February 16, 2017
    Inventors: Fiona KAPER, Jian-Bing FAN, Neeraj SALATHIA, Gordon M. CANN, Arash JAMSHIDI, Alex ARAVANIS
  • NUCLEIC ACID SEQUENCE ANALYSIS FROM SINGLE CELLS
    Publication number: 20160053253
    Abstract: Presented herein are methods and compositions for multiplexed single cell gene expression analysis. Some methods and compositions include the use of droplets and/or beads bearing unique barcodes such as unique molecular barcodes (UMI).
    Type: Application
    Filed: September 15, 2015
    Publication date: February 25, 2016
    Applicant: ILLUMINA, INC.
    Inventors: Neeraj SALATHIA, Jian-Bing FAN