Abstract: Disclosed herein are heterocyclic compounds, for example, according to the following formula and analogs thereof: that inhibit the activity of FLT3. Also described are specific covalent inhibitors of FLT3. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the FLT3 inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of proliferative diseases or conditions, including hematological malignancies and other diseases or conditions dependent on FLT3 activity.

Abstract: The present invention provides a recombinant cell for producing para-nitro-L-phenylalanine (pN-Phe). The recombinant cell comprises heterologous genes encoding heterologous enzymes. The recombinant cell expresses the heterologous enzymes and contains a native metabolite. The native metabolite is converted to the pN-Phe in the recombinant cell. The biosynthesized pN-Phe may be incorporated into a target polypeptide in the recombinant cell without requiring exposure of the recombinant cell to exogenous pN-Phe. A cell culture comprising the recombinant cell is also provided. Further provided is a method of producing pN-Phe by a recombinant cell comprising heterologous genes encoding heterologous enzymes. The method comprises expressing a native metabolite by the recombinant cell, expressing the heterologous enzymes, and converting the native metabolite to the pN-Phe in the recombinant cell. The method may further comprise incorporating the pN-Phe into the target polypeptide in the recombinant cell.

Abstract: A modified dryer operates on a different principle from that used by the prior torrefaction plants. The subject invention utilizes thermal conduction to torrefy the biomass in a vibratory reactor in which a heated solid unperforated plate is sealed in the reactor to separate the biomass above from the gas used to heat the plate below. This permits using inert flue gas to heat the reactor which in turn permits the use of a cool air damping system to prevent thermal runaway. Also syngas evolved from the process is utilized to power a gas engine, the exhaust output of which is recirculated to heat the reactor plate. When the gas engine is coupled to an electric generator, waste energy is recovered for use in other parts of the plant or exported elsewhere.

Abstract: A modified dryer operates on a different principle from that used by the prior torrefaction plants. The subject invention utilizes thermal conduction to torrefy the biomass in a vibratory reactor in which a heated solid unperforated plate is sealed in the reactor to separate the biomass above from the gas used to heat the plate below. This permits using inert flue gas to heat the reactor which in turn permits the use of a cool air damping system to prevent thermal runaway. Also syngas evolved from the process is utilized to power a gas engine, the exhaust output of which is recirculated to heat the reactor plate. When the gas engine is coupled to an electric generator, waste energy is recovered for use in other parts of the plant or exported elsewhere.

Abstract: A modified dryer operates on a different principle from that used by the prior torrefaction plants. The subject invention utilizes thermal conduction to torrefy the biomass in a vibratory reactor in which a heated solid unperforated plate is sealed in the reactor to separate the biomass above from the gas used to heat the plate below. This permits using inert flue gas to heat the reactor which in turn permits the use of a cool air damping system to prevent thermal runaway. Also syngas evolved from the process is utilized to power a gas engine, the exhaust output of which is recirculated to heat the reactor plate. When the gas engine is coupled to an electric generator, waste energy is recovered for use in other parts of the plant or exported elsewhere.

Abstract: A modified dryer operates on a different principle from that used by the prior torrefaction plants. The subject invention utilizes thermal conduction to torrefy the biomass in a vibratory reactor in which a heated solid unperforated plate is sealed in the reactor to separate the biomass above from the gas used to heat the plate below. This permits using inert flue gas to heat the reactor which in turn permits the use of a cool air damping system to prevent thermal runaway. Also syngas evolved from the process is utilized to power a gas engine, the exhaust output of which is recirculated to heat the reactor plate. When the gas engine is coupled to an electric generator, waste energy is recovered for use in other parts of the plant or exported elsewhere.

Abstract: The invention concerns an electrochemical cell which, either alone or together which a substrate onto which it is placed, is in the form of a receptacle. The electrochemical cell contains a working electrode and a counter electrode, the working electrode being in a wall of the receptacle. At least one of the electrodes has at least one dimension of less than 50 ?m. The electrochemical cell is principally intended for use as a micro-electrode suitable for screening water, blood, urine or other biological or non-biological fluids.

Abstract: Systems and methods for the extraction, incineration and monitoring of methane gas extracted from a mine are described herein. In some embodiments, a system includes a transportation platform, a fluid machine coupled to the transportation platform, an incinerator, a vent assembly and a flow interface assembly. The fluid machine is configured to be coupled to a gas well, and to produce a gas flow from the gas well. The incinerator is configured to be fluidically coupled to the fluid machine, and is configured to combust at least a portion of the gas flow from the gas well. The vent assembly is configured to be fluidically coupled to the fluid machine. The flow interface assembly is coupled to the transportation platform and is configured to selectively place the fluid machine in fluid communication with any one of the incinerator and the vent assembly.

Abstract: A heat exchanger for a regenerative thermal oxidiser is described. The heat exchanger has a heat exchange bed that is disposed within a housing. The heat exchange bed is disposed parallel to the longest axis of the housing. A cavity is formed at either side of the heat exchange bed. Channels in the heat exchange bed link the two cavities. Because the heat exchange bed is disposed parallel to the longest axis of the housing, the area of the heat exchange bed facing the cavities is maximised, and the length of the channels is minimised, this reduces the pressure required to drive gas through the heat exchanger.

Abstract: A process for preparing a printed substrate which comprises: (a) printing the desired pattern on to a release film, (b) adhering a substrate layer to the patterned side of the printed release film substrate, and (c) removing the release film, thereby producing a substrate bearing a print, the flatness of the surface of which corresponds to that of the film.

Abstract: A method consists in assigning an authorization level (AUTH) to a client object and a "dynamic" sensitivity level (DSL) to a method (or data processing procedure) of a server object (ProcObjSv). The dynamic sensitivity level is computed based on static sensitivity levels (SSLs) at the moment when the server object is instantiated. The authorization level of the client object is passed to the method of the server object when the method of the server object is invoked by the client object, and this authorization level (AUTH) is compared with the dynamic sensitivity level (DSL) of the method in order to control access. The method makes it possible to implement a multi-level security model.