Abstract: The present invention provides methods for treating, preventing or reducing the severity of allergic reactions. The present invention also provides methods for enhancing the efficacy and/or safety of an allergen-specific immunotherapy (SIT) regimen. The methods of the present invention comprise administering to a subject in need thereof a therapeutic composition comprising an interleukin-4 receptor (IL-4R?) antagonist such as an anti-IL-4R? antibody.

Abstract: The present invention provides methods for treating moderate-to-severe or severe atopic dermatitis (AD). The methods of the present invention comprise administering to a subject in need thereof one or more doses of an interleukin-4 receptor (IL-4R) inhibitor such as an anti-IL-4R antibody. In certain embodiments, the methods of the present invention are used to treat severe AD in a patient whose disease is not controlled with systemic therapy (e.g., cyclosporine A) or when such therapy is inadvisable.

Abstract: The present invention provides methods for treating or preventing asthma and associated conditions in a patient. The methods of the present invention comprise administering to a subject in need thereof a therapeutic composition comprising an interleukin-4 receptor (IL-4R) antagonist, such as an anti-IL-4R antibody.

Abstract: The present invention provides methods for treating atopic dermatitis (AD). Also provided are methods for improving one or more AD-associated parameter(s), and methods for decreasing the level of at least one AD-associated biomarker in a subject in need thereof. The methods of the present invention comprise administering to a subject in need thereof a pharmaceutical composition comprising an interleukin-4 receptor (IL-4R) antagonist such as an anti-IL-4R antibody.

Abstract: A power train for an amphibian includes a first prime mover, a first speed change transmission, a first land propulsion unit and a first marine propulsion unit. The first prime mover is arranged to selectively drive the first land propulsion unit and the first marine propulsion unit through the first speed change transmission. The power train further comprises a second prime mover, a second speed change transmission, a second land propulsion unit and a second marine propulsion unit. The second prime mover is arranged to selectively drive at least one of the second land propulsion unit and a second marine propulsion unit through the second speed change transmission.

Abstract: There is provided a diagnostic reagent for use in the detection of M. bovis or M. tuberculosis infection in an animal, comprising a peptide which has an epitope from Mycobacterium bovis hypothetic protein Mb3645c (SEQ ID NO: 1) or an epitope from a polypeptide having at least 76% identity with SEQ ID NO: 1.

Abstract: The present invention provides compositions and methods of for improving the Health-Related Quality of Life of a subject suffering from rheumatoid arthritis, comprising administering to the subject an effective amount of sarilumab.

Abstract: The present invention provides methods for enhancing the efficacy and/or safety of a vaccine. In certain embodiments, the invention provides methods to increase or potentiate the immune response to a vaccine in a subject in need thereof. The methods of the present invention comprise administering to a subject in need thereof an interleukin-4 receptor (IL-4R) antagonist such as an anti-IL-4R antibody in combination with said vaccine. In certain embodiments, the methods of the present invention are used to afford enhanced protection to an infectious disease such as whooping cough.

Abstract: A watercraft or amphibian includes a prime mover operable with at least a first and a second idle speed, a marine propulsion device operable to generate thrust when connected to the prime mover, and a determining arrangement for determining whether or not the watercraft or amphibian is operating at or above a determined speed of travel, wherein the second idle speed of the prime mover is higher than the first idle speed, the marine propulsion device generates a steerable thrust when operated by the prime mover at a speed at or above the second idle speed, and wherein the prime mover is operated with the second idle speed when the determining arrangement determines the watercraft or amphibian is operating at or above the determined speed of travel.

Abstract: There is provided a diagnostic reagent for use in the detection of M. bovis or M. tuberculosis infection in an animal, comprising a peptide which has an epitope from Mycobacterium bovis hypothetic protein Mb3645c (SEQ ID NO: 1) or an epitope from a polypeptide having at least 76% identity with SEQ ID NO: 1.

Abstract: The present invention provides methods for treating or preventing asthma and associated conditions in a patient. The methods of the present invention comprise administering to a subject in need thereof a therapeutic composition comprising an interleukin-4 receptor (IL-4R) antagonist, such as an anti-IL-4R antibody.

Abstract: A power train for an amphibian includes a first prime mover, a first land propulsion unit, and a first marine propulsion unit. The first prime mover is arranged to selectively drive the first land propulsion unit, or the first marine propulsion unit, or both. The power train further comprises a second prime mover. The second prime mover is arranged to selectively drive the first land propulsion unit, or the first marine propulsion unit, or both, either in place of the first prime mover or in addition thereto.

Abstract: There is provided a diagnostic reagent for use in the detection of M. bovis or M. tuberculosis infection in an animal, comprising a peptide which has an epitope from Mycobacterium bovis hypothetic protein Mb3645c (SEQ ID NO: 1) or an epitope from a polypeptide having at least 76% identity with SEQ ID NO: 1.

Abstract: There is provided a diagnostic reagent for use in the detection of M. bovis or M. tuberculosis infection in an animal, comprising a peptide which has an epitope from Mycobacterium bovis hypothetic protein Mb3645c (SEQ ID NO: 1) or an epitope from a polypeptide having at least 76% identity with SEQ ID NO: 1.

Abstract: A wheel suspension and retraction apparatus (2) for an amphibious vehicle comprises a suspension unit having transverse upper and lower suspension links (4, 8); spring and damper unit (12), and suspension upright (6) supporting wheel (10), and pivotally connected to outboard ends of links (4 and 8). The wheel retraction mechanism has a retraction linkage (14, 16, 18), pivotably connectable to the vehicle, and an actuator (38) for moving the wheel suspension between a protracted position for land use and a retracted position for use on water. The retraction mechanism supports the suspension unit spaced apart transversely from the vehicle. Tie bar (16) is connected to upper retraction arm (14) at an intermediate location (30) to ensure a large angle of tilt on retraction, to ensure that the wheel is retracted above hull line (156). The wheel suspension does not have to be compressed on retraction.

Abstract: A watercraft or amphibian includes a prime mover operable with at least a first and a second idle speed, a marine propulsion device operable to generate thrust when connected to the prime mover, and a determining arrangement for determining whether or not the watercraft or amphibian is operating at or above a determined speed of travel, wherein the second idle speed of the prime mover is higher than the first idle speed, the marine propulsion device generates a steerable thrust when operated by the prime mover at a speed at or above the second idle speed, and wherein the prime mover is operated with the second idle speed when the determining arrangement determines the watercraft or amphibian is operating at or above the determined speed of travel.

Abstract: The invention provides methods for treating or preventing asthma and associated conditions in a patient. The methods featured in the invention comprise administering to a subject in need thereof a therapeutic composition comprising an interleukin-4 receptor (IL-4R) antagonist, such as an anti-IL-4R antibody.

Abstract: The present invention provides methods for treating, preventing or ameliorating skin infections, including bacterial and viral infections. In certain embodiments, the invention provides methods to reduce skin infection in a patient with atopic dermatitis (AD). Also provided are methods for improving skin barrier function, and methods for reducing the risk of inflammation due to microbial infection in a patient in need thereof. The methods of the present invention comprise administering to a patient in need thereof a pharmaceutical composition comprising an interleukin-4 receptor (IL-4R) antagonist such as an anti-IL-4R antibody.

Abstract: A wheel suspension and retraction apparatus (2) for an amphibious vehicle comprises a suspension unit having transverse upper and lower suspension links (4, 8); spring and damper unit (12), and suspension upright (6) supporting wheel (10), and pivotally connected to outboard ends of links (4 and 8). The wheel retraction mechanism has a retraction linkage (14, 16, 18), pivotably connectable to the vehicle, and an actuator (38) for moving the wheel suspension between a protracted position for land use and a retracted position for use on water. The retraction mechanism supports the suspension unit spaced apart transversely from the vehicle. Tie bar (16) is connected to upper retraction arm (14) at an intermediate location (30) to ensure a large angle of tilt on retraction, to ensure that the wheel is retracted above hull line (156). The wheel suspension does not have to be compressed on retraction.

Abstract: A power train for an amphibian includes a first prime mover, a first land propulsion unit, and a first marine propulsion unit. The first prime mover is arranged to selectively drive the first land propulsion unit, or the first marine propulsion unit, or both. The power train further comprises a second prime mover. The second prime mover is arranged to selectively drive the first land propulsion unit, or the first marine propulsion unit, or both, either in place of the first prime mover or in addition thereto.