Abstract: Nasal cannula assemblies for providing respiratory therapy to patients are provided. A nasal cannula assembly can include a cannula, an optional manifold which may be removable, a gas supply tube, and a securement mechanism. Securement mechanisms can include headgear straps, cheek pads, or an adhesive nose strip. A nasal cannula assembly can also include a lanyard, lanyard clip, and/or lanyard connector to help support the weight of a main gas delivery conduit.

Abstract: A network computing system can coordinate on-demand transport serviced by transport providers operating throughout a transport service region. The transport providers can comprise a set of internal autonomous vehicles (AVs) and a set of third-party AVs. The system can receive a transport request from a requesting user of the transport service region, where the transport request indicates a pick-up location and a destination. The system can determine a subset of the transport providers to service the respective transport request, and executing a selection process among the subset of the transport providers to select a transport provider to service the transport request. The system may then transmit a transport assignment to the selected transport provider to cause the selected transport provider to service the transport request.

Abstract: The disclosure relates to a patient interface for non-invasive ventilation. The patient interface is configured to seal about the mouth and nares of a patient and includes an outer wall defining an interior volume which includes a first chamber having one or more oral openings to communicate gas with the mouth and a second chamber having one or more nare openings to communicate gas with the nares. The patient interface further includes a dividing wall that separates the first chamber from the second chamber. The patient interface further includes one or more flow directors which enable gas to flow into the second chamber from the first chamber the first chamber from the second chamber. The one or more flow directors are configured to direct the gas flow through the one or more nare openings.

Abstract: Nasal cannula assemblies for providing respiratory therapy to patients are provided. A nasal cannula assembly can include a cannula, an optional manifold which may be removable, a gas supply tube, and a securement mechanism. Securement mechanisms can include headgear straps, cheek pads, or an adhesive nose strip. A nasal cannula assembly can also include a lanyard, lanyard clip, and/or lanyard connector to help support the weight of a main gas delivery conduit.

Abstract: Compositions and methods for modifying genomic DNA sequences are provided. The methods produce double-stranded breaks (DSBs) at pre-determined target sites in a genomic DNA sequence, resulting in mutation, insertion, and/or deletion of DNA sequences at the target site(s) in a genome. Compositions comprise DNA constructs comprising nucleotide sequences that encode a Cms1 protein operably linked to a promoter that is operable in the cells of interest. The DNA constructs can be used to direct the modification of genomic DNA at pre-determined genomic loci. Methods to use these DNA constructs to modify genomic DNA sequences are described herein. Additionally, compositions and methods for modulating the expression of genes are provided.

Abstract: Compositions and methods for modifying genomic DNA sequences are provided. The methods produce double-stranded breaks (DSBs) at pre-determined target sites in a genomic DNA sequence, resulting in mutation, insertion, and/or deletion of DNA sequences at the target site(s) in a genome. Compositions comprise DNA constructs comprising nucleotide sequences that encode a Cms1 protein operably linked to a promoter that is operable in the cells of interest. The DNA constructs can be used to direct the modification of genomic DNA at pre-determined genomic loci. Methods to use these DNA constructs to modify genomic DNA sequences are described herein. Additionally, compositions and methods for modulating the expression of genes are provided.

Abstract: The invention relates to systems for securing a tube (e.g. feeding tube) and/or a patient interface or a dermal patch to a user. One embodiment comprises a holder, an interface side of the holder attachable to the patient interface or the dermal patch for securing a feeding tube to the patient interface or the patch, the holder comprising at least a first channel or recess for receiving the feeding tube to couple the feeding tube to the patient interface. Another embodiment comprises a patient interface itself comprising a backing for positioning on a patient's face, a dermal patch having a patient side and an interface side, the patient side of the patch attachable to the user, the patch comprising at least a first flap portion attachable to the tube for affixing the tube to the patch, a two-part releasable connection arrangement for releasably securing the patient interface to the patch.

Abstract: Compositions and methods for targeting pre-determined DNA sequences in bacterial cells are provided. The methods result in the targeted elimination of bacterial cells that comprise the pre-determined DNA sequence(s). Compositions comprise DNA constructs comprising nucleotide sequences that encode a Cms1 protein operably linked to a promoter that is operable in the cells of interest. Methods to use these DNA constructs to selectively target and eliminate bacterial cells that harbor the targeted DNA sequence(s) are described herein.

Abstract: Medical breathing tubes have a tubular body that defines a lumen extending between open terminal ends of the tubular body. An internal form is enclosed within the lumen and supportive of the tubular body. The internal form may be a coated encapsulated internal form where the coating secures the internal form to the tubular body. The internal form may provide for a series of alternative crests and troughs of the tubular body. A patient interface and/or a securement system may be attached to the tubular body.

Abstract: Respiratory equipment packaging and insert for a respiratory interface assembly having a respiratory interface and headgear. The packaging includes a first pocket having a first opening, and being configured to enclose and sealing retain at least the respiratory interface and the headgear of the respiratory assembly, and a second pocket, adjacent the first pocket and having a second opening. The second pocket is configured to receive an auxiliary device intended for use with, or comprising part of, the respiratory interface assembly, such as a mask size measuring device. The insert is configured to support the respiratory interface in an upright orientation and includes at least one slot configured to receive a strap of the headgear of the respiratory interface assembly.

Abstract: The invention relates to systems for securing a tube (e.g. feeding tube) and/or a patient interface or a dermal patch to a user. One embodiment comprises a holder, an interface side of the holder attachable to the patient interface or the dermal patch for securing a feeding tube to the patient interface or the patch, the holder comprising at least a first channel or recess for receiving the feeding tube to couple the feeding tube to the patient interface. Another embodiment comprises a patient interface itself comprising a backing for positioning on a patient's face, a dermal patch having a patient side and an interface side, the patient side of the patch attachable to the user, the patch comprising at least a first flap portion attachable to the tube for affixing the tube to the patch, a two-part releasable connection arrangement for releasably securing the patient interface to the patch.

Abstract: A cushion module for a patient interface is disclosed. The cushion module comprising a first cavity, a second cavity, a nasal aperture and an oral aperture. The first and second cavities are separated by a cavity wall that enables respiratory gas to flow within the cushion module between the first and second cavities when in use. Additionally, the first cavity is configured to communicate respiratory gas to both the mouth and the nares of a patient via the oral aperture and the nasal aperture respectively. The cushion module comprises an exhaust vent to communicate respiratory gas from within the cushion module to externally of the cushion module and the second cavity is in communication with the exhaust vent. Also disclosed are a cavity wall and a cushion module.

Abstract: Medical breathing tubes have a tubular body that defines a lumen extending between open terminal ends of the tubular body. An internal form is enclosed within the lumen and supportive of the tubular body. The internal form may be a coated encapsulated internal form where the coating secures the internal form to the tubular body. The internal form may provide for a series of alternative crests and troughs of the tubular body. A patient interface and/or a securement system may be attached to the tubular body.

Abstract: Compositions and methods for improving plant growth are provided herein. Disclosed herein are polypeptides encompassing m-type thioredoxin proteins, and polynucleotides encoding m-type thioredoxin proteins, wherein the thioredoxin protein-encoding sequence is expressed from mesophyll-preferred promoters. Also provided herein are expression constructs for expressing genes of interest whose expression may improve agronomic properties including but not limited to crop yield, biotic and abiotic stress tolerance, and early vigor, plants comprising the polynucleotides, polypeptides, and expression constructs, and methods of producing transgenic plants.

Abstract: Compositions and methods for improving plant growth are provided herein. Polynucleotides encoding glutaredoxin proteins, polypeptides encompassing glutaredoxin proteins, and expression constructs for expressing genes of interest whose expression may improve agronomic properties including but not limited to crop yield, biotic and abiotic stress tolerance, and early vigor, plants comprising the polynucleotides, polypeptides, and expression constructs, and methods of producing transgenic plants are also provided.

Abstract: Respiratory equipment packaging and insert for a respiratory interface assembly having a respiratory interface and headgear. The packaging includes a first pocket having a first opening, and being configured to enclose and sealing retain at least the respiratory interface and the headgear of the respiratory assembly, and a second pocket, adjacent the first pocket and having a second opening. The second pocket is configured to receive an auxiliary device intended for use with, or comprising part of, the respiratory interface assembly, such as a mask size measuring device. The insert is configured to support the respiratory interface in an upright orientation and includes at least one slot configured to receive a strap of the headgear of the respiratory interface assembly.

Abstract: A headgear connector is provided for connecting a user interface to a headgear strap. The headgear connector comprises a headgear receiving passage configured to receive a headgear strap from a first direction and to enable the headgear strap to loop back onto itself in a second direction substantially opposed to the first direction, and a gripping element configured to grip a portion of the headgear strap to secure the headgear strap with respect to the user interface. Headgear is also provided.

Abstract: Compositions and methods for improving plant growth are provided herein. Polynucleotides encoding photosystem I reaction center subunit N (PSAN) proteins, polypeptides encompassing PSAN proteins, and expression constructs for expressing genes of interest whose expression may improve agronomic properties including but not limited to crop yield, biotic and abiotic stress tolerance, and early vigor, plants comprising the polynucleotides, polypeptides, and expression constructs, and methods of producing transgenic plants are also provided.